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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2020-10-2-119-130</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-1023</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>Антибактериальная профилактика инфекционного эндокардита: от истории концепции до современных рекомендаций (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Antibiotic Prophylaxis of Infective Endocarditis: From the History of the Concept to Modern Recommendations (Review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3984-8482</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарадин</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Taradin</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Геннадий Геннадьевич Тарадин</p></bio><bio xml:lang="en"><p>Gennadiy G. Taradin</p><p>Donetsk</p></bio><email xlink:type="simple">taradin@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономарева</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomareva</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Игнатенко</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ignatenko</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ватутин</surname><given-names>Н. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Vatutin</surname><given-names>N. T.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прендергаст</surname><given-names>Б. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Prendergast</surname><given-names>B. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Отделение кардиологии</p><p>Лондон</p></bio><bio xml:lang="en"><p>Department of Cardiology</p><p>London</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»;&#13;
ГУ «Институт неотложной и восстановительной хирургии им. В.К. Гусака»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Educational Organization of Higher Professional Education «M. Gorky Donetsk National Medical University»;&#13;
State Institution «V.K. Gusak Institute of Urgent and Recovery Surgery»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Саратовский ГМУ им. В.И. Разумовского Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education «Saratov State Medical University named after V.I. Razumovsky»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Educational Organization of Higher Professional Education «M. Gorky Donetsk National Medical University»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Госпиталь Св. Томаса</institution><country>Великобритания</country></aff><aff xml:lang="en"><institution>St. Thomas Hospital</institution><country>United Kingdom</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>31</day><month>03</month><year>2020</year></pub-date><volume>10</volume><issue>2</issue><fpage>119</fpage><lpage>130</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тарадин Г.Г., Пономарева Е.Ю., Игнатенко Г.А., Ватутин Н.Т., Прендергаст Б.Д., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Тарадин Г.Г., Пономарева Е.Ю., Игнатенко Г.А., Ватутин Н.Т., Прендергаст Б.Д.</copyright-holder><copyright-holder xml:lang="en">Taradin G.G., Ponomareva E.Y., Ignatenko G.A., Vatutin N.T., Prendergast B.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/1023">https://www.medarhive.ru/jour/article/view/1023</self-uri><abstract><p>В настоящем обзоре освещаются современные представления о профилактике инфекционного эндокардита. Описывается история развития концепции антибактериальной профилактики инфекционного эндокардита, основные подходы и обоснование изменения принципов антибактериальной профилактики в последние годы. Подробно освещаются последние принятые международные и национальные рекомендации, в частности, Европейского общества кардиологов, Американской ассоциации сердца/Американской коллегии кардиологов и Японского общества по кровообращению. Представлена критическая оценка принятых ранее международных рекомендаций с анализом влияния частичного или полного ограничения антибактериальной профилактики на заболеваемость инфекционного эндокардита и частоту его осложнений.</p></abstract><trans-abstract xml:lang="en"><p>The presented review highlights current understandings of prophylaxis for infective endocarditis (IE). The historic aspects of the concept development of antibacterial prophylaxis (ABP) for IE, the main approaches and the rationale for changing the principles of ABP in recent years are described. There are detailed clarifications of published international and national recommendations, in particular, of European Society of Cardiology, National Institute for Health and Clinical Excellence, American Heart Association/American College of Cardiology and Japanese Circulation Society. The critical estimation of earlier adopted international guidelines with analysis of influence of partial or absolute ABP restrictions on the incidence of IE and its complications including fatality rate are presented.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит</kwd><kwd>профилактика</kwd><kwd>антибиотики</kwd><kwd>антибактериальная профилактика</kwd><kwd>международные рекомендации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infective endocarditis</kwd><kwd>prophylaxis</kwd><kwd>antibiotics</kwd><kwd>antibacterial prophylaxis</kwd><kwd>international guidelines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Демин А.А. Инфекционный эндокардит (профилактика, диагностические критерии и лечение): ключевые положения 2010. 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