avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2020-10-4-254-261avk-1070Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESФактор роста соединительной ткани в норме и патологииConnective Tissue Growth Factor in Normal and Pathological Processeshttps://orcid.org/0000-0002-4131-8432ТополянскаяС. В.TopolyanskayaS. V.

Москва

Moscow

sshekshina@yahoo.comФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения РФ (Сеченовский Университет), кафедра госпитальной терапии № 2РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), RF Health Ministry, Hospital Therapy Department № 2Russian Federation202029072020104254261Copyright © Тополянская С.В., 20202020Тополянская С.В.Topolyanskaya S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/1070

В обзоре отражены современные представления о роли фактора роста соединител ьной ткани при различных физиологических и патологических процессах. Фактор роста соединительной ткани регулирует разнообразные клеточные функции, в том числе, пролиферацию, миграцию, адгезию, дифференцировку и синтез белков внеклеточного матрикса в клетках различных типов, а также участвует в более сложных биологических процессах ангиогенеза, хондрогенеза, остеогенеза, заживления ран, фиброза и онкогенеза. Повышенная экспрессия фактора роста соединительной ткани наблюдается при различных сердечно-сосудистых и онкологических заб олеваниях. В обзоре обсуждается также потенциальная роль этого фактора роста в регуляции процессов клеточного старения.

Modern concepts about the role of connective tissue growth factor in various physiological and pathological processes are described in the review. Connective tissue growth factor regulates a variety of cellular functions, including proliferation, migration, adhesion, differentiation and synthesis of extracellular matrix proteins in cells of different types. This factor is also involved in more complex biological processes of angiogenesis, chondrogenesis, wound healing, fibrosis and oncogenesis. Increased expression of connective tissue growth factor is observed in different cardiovascular and oncological diseases. Potential role of this growth factor in regulation of cellular senescence and aging processes is also discussed.

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The authors declare that there are no conflicts of interest present.