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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2021-11-1-60-66</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-1121</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РАЗБОР КЛИНИЧЕСКИХ СЛУЧАЕВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANALYSIS OF CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Случай брадикардии, развившейся на фоне гиперкалиемии у пациентки отделения амбулаторного гемодиализа</article-title><trans-title-group xml:lang="en"><trans-title>The Case of Bradycardia Occured in the Setting of Hyperkalemia in a Patient in Ambulatory Hemodialysis Department</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3611-1186</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Игнатенко</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ignatenko</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Донецк</p></bio><bio xml:lang="en"><p>Donetsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3984-8482</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тарадин</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Taradin</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Геннадий Геннадьевич Тарадин</p><p>Донецк</p></bio><bio xml:lang="en"><p>Gennady G. Taradin</p><p>Donetsk</p></bio><email xlink:type="simple">taradin@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0295-3724</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багрий</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagry</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Донецк</p></bio><bio xml:lang="en"><p>Donetsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2694-6614</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ракитская</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakitskaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Донецк</p></bio><bio xml:lang="en"><p>Donetsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Могилевская</surname><given-names>К. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Mogilevskaya</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Донецк</p></bio><bio xml:lang="en"><p>Donetsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меркурьев</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Merkuriev</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Донецк</p></bio><bio xml:lang="en"><p>Donetsk</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9954-4715</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Христуленко</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Khristulenko</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Донецк</p></bio><bio xml:lang="en"><p>Donetsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»</institution><country>Украина</country></aff><aff xml:lang="en"><institution>State Educational Organization of Higher Professional Education «M. Gorky Donetsk National Medical University»</institution><country>Ukraine</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»; ГУ «Институт неотложной и восстановительной хирургии им. В.К. Гусака»</institution><country>Украина</country></aff><aff xml:lang="en"><institution>State Educational Organization of Higher Professional Education «M. Gorky Donetsk National Medical University»; State Institution «V.K. Gusak Institute of Urgent and Recovery Surgery»</institution><country>Ukraine</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>КУ «Центральная городская клиническая больница № 1»</institution><country>Украина</country></aff><aff xml:lang="en"><institution>Clinical Institution «Central City Clinical Hospital № 1»</institution><country>Ukraine</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>01</month><year>2021</year></pub-date><volume>11</volume><issue>1</issue><fpage>60</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Игнатенко Г.А., Тарадин Г.Г., Багрий А.Э., Ракитская И.В., Могилевская К.Э., Меркурьев В.И., Христуленко А.Л., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Игнатенко Г.А., Тарадин Г.Г., Багрий А.Э., Ракитская И.В., Могилевская К.Э., Меркурьев В.И., Христуленко А.Л.</copyright-holder><copyright-holder xml:lang="en">Ignatenko G.A., Taradin G.G., Bagry A.E., Rakitskaya I.V., Mogilevskaya K.E., Merkuriev V.I., Khristulenko A.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/1121">https://www.medarhive.ru/jour/article/view/1121</self-uri><abstract><p>В статье представлено клиническое наблюдение развития брадикардии у 64-летней пациентки с хроническим заболеванием почек, находящейся на лечении в отделении амбулаторного гемодиализа. При регистрации электрокардиограммы была зафиксирована аритмия в виде ритма из атриовентрикулярного соединения. Характерные изменения на электрокардиограмме, наличие факторов риска, данные дополнительно собранного анамнеза позволили предположить развитие опасного состояния — гиперкалиемии. Диагноз подтвердился после определения уровня сывороточного калия. Приведенный случай иллюстрирует необходимость рассматривать вероятность гиперкалиемии у пациентов с хроническим заболеванием почек, включая находящихся на гемодиализе. При возникновении характерных клинических проявлений и изменений на электрокардиограмме необходимо как можно быстрее определить сывороточное содержание калия для своевременной и адекватной коррекции электролитного нарушения.</p></abstract><trans-abstract xml:lang="en"><p>The presented article contains the clinical observation of bradycardia development in 64-year-old patient with chronic kidney disease who was in ambulatory treatment at the hemodialysis department. During electrocardiogram recording an arrhythmia was detected as a junctional rhythm. The specific changes on electrocardiogram, presence of risk factors, and data of additional collection of history disease allowed purposing the development of dangerous condition — hyperkalemia. The diagnosis was confirmed after detection of the serum potassium level. This case illustrates the necessity to consider the possibility of hyperkalemia in patients with chronic kidney diseases including those who undergoing hemodialysis treatment. Relevant clinical manifestations and changes on the electrocardiogram require the urgent assessment of the serum potassium level for timely and adequate correction of the electrolyte disorder.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>брадикардия</kwd><kwd>узловой ритм</kwd><kwd>нарушения ритма сердца</kwd><kwd>гиперкалиемия</kwd><kwd>калий</kwd><kwd>факторы риска</kwd><kwd>хроническое заболевание почек</kwd><kwd>гемодиализ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bradycardia</kwd><kwd>junctional rhythm</kwd><kwd>cardiac arrhythmias</kwd><kwd>hyperkalemia</kwd><kwd>potassium</kwd><kwd>risk factors</kwd><kwd>chronic kidney disease</kwd><kwd>hemodialysis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dhondup T, Qian Q. Electrolyte and acid-base disorders in chronic kidney disease and end-stage kidney failure. Blood Purif. 2017; 43(1-3): 179-188. doi: 10.1159/000452725.</mixed-citation><mixed-citation xml:lang="en">Dhondup T, Qian Q. Electrolyte and acid-base disorders in chronic kidney disease and end-stage kidney failure. Blood Purif. 2017; 43(1-3): 179-188. doi: 10.1159/000452725.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Soar J, Perkins GD, Abbas G, et al. European resuscitation council guidelines for resuscitation 2010 Section 8. Cardiac arrest in special circumstances: electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution. Resuscitation. 2010 Oct; 81(10): 1400-1433. doi: 10.1016/j.resuscitation.2010.08.015.</mixed-citation><mixed-citation xml:lang="en">Soar J, Perkins GD, Abbas G, et al. European resuscitation council guidelines for resuscitation 2010 Section 8. Cardiac arrest in special circumstances: electrolyte abnormalities, poisoning, drowning, accidental hypothermia, hyperthermia, asthma, anaphylaxis, cardiac surgery, trauma, pregnancy, electrocution. Resuscitation. 2010 Oct; 81(10): 1400-1433. doi: 10.1016/j.resuscitation.2010.08.015.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Littmann L, Gibbs MA. Electrocardiographic manifestations of severe hyperkalemia. J Electrocardiol. Sep-Oct 2018; 51(5): 814-817. doi: 10.1016/j.jelectrocard.2018.06.018.</mixed-citation><mixed-citation xml:lang="en">Littmann L, Gibbs MA. Electrocardiographic manifestations of severe hyperkalemia. J Electrocardiol. Sep-Oct 2018; 51(5): 814-817. doi: 10.1016/j.jelectrocard.2018.06.018.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Palaka E, Grandy S, Darlington O, et al. Associations between serum potassium and adverse clinical outcomes: a systematic literature review. Int J Clin Pract. 2020 Jan; 74(1): e13421. doi: 10.1111/ijcp.13421.</mixed-citation><mixed-citation xml:lang="en">Palaka E, Grandy S, Darlington O, et al. Associations between serum potassium and adverse clinical outcomes: a systematic literature review. Int J Clin Pract. 2020 Jan; 74(1): e13421. doi: 10.1111/ijcp.13421.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Montford JR, Linas S. How dangerous is hyperkalemia? J Am Soc Nephrol. 2017 Nov; 28(11): 3155-3165. doi: 10.1681/ASN.2016121344.</mixed-citation><mixed-citation xml:lang="en">Montford JR, Linas S. How dangerous is hyperkalemia? J Am Soc Nephrol. 2017 Nov; 28(11): 3155-3165. doi: 10.1681/ASN.2016121344.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Дядык А.И., Тарадин Г.Г., Сулиман Ю.В. и др. Диуретики при хронической болезни почек. Архивъ внутренней медицины. 2020; 10(1): 10-20. DOI: 10.20514/2226-6704-2020-10-1-10-20</mixed-citation><mixed-citation xml:lang="en">Dyadyk A.I., Taradin G.G., Suliman Yu.V. i dr. Diuretics in chronic kidney disease. The Russian Archives of Internal Medicine. 2020; 10(1): 10-20. DOI: 10.20514/2226-6704-2020-10-1-10-20 [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rodan AR. Potassium: friend or foe? Pediatr Nephrol. 2017 Jul; 32(7): 1109-1121. doi: 10.1007/s00467-016-3411-8.</mixed-citation><mixed-citation xml:lang="en">Rodan AR. Potassium: friend or foe? Pediatr Nephrol. 2017 Jul; 32(7): 1109-1121. doi: 10.1007/s00467-016-3411-8.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Durfey N, Lehnhof B, Bergeson A, et al. Severe hyperkalemia: can the electrocardiogram risk stratify for short-term adverse events? West J Emerg Med. 2017 Aug; 18(5): 963-971. doi: 10.5811/westjem.2017.6.33033</mixed-citation><mixed-citation xml:lang="en">Durfey N, Lehnhof B, Bergeson A, et al. Severe hyperkalemia: can the electrocardiogram risk stratify for short-term adverse events? West J Emerg Med. 2017 Aug; 18(5): 963-971. doi: 10.5811/westjem.2017.6.33033</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Goldberger’s clinical electrocardiography: a simplified approach / Ary L. Goldberger, Zachary D. Goldberger, Alexei Shvilkin.− 8th ed. 2013. — p. 92-100.</mixed-citation><mixed-citation xml:lang="en">Goldberger’s clinical electrocardiography: a simplified approach / Ary L. Goldberger, Zachary D. Goldberger, Alexei Shvilkin.− 8th ed. 2013. — p. 92-100.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ватутин Н.Т., Шевелек А.Н., Карапыш В.А. и др. Атриовентрикулярные блокады: прошлое и настоящее. Аритмологiя 2014; 10(2): 26-35.</mixed-citation><mixed-citation xml:lang="en">Vatutin N.T., Shevelek A.N., Karapysh V.A. et al. Atrioventricular block: the past and the present. Aritmologiya = Arrhythmology. 2014;10(2);26-35. [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Montague BT, Ouellette JR, Buller GK. Retrospective review of the frequency of ECG changes in hyperkalemia. Clin J Am Soc Nephrol. 2008 Mar; 3(2): 324-330. doi: 10.2215/CJN.04611007.</mixed-citation><mixed-citation xml:lang="en">Montague BT, Ouellette JR, Buller GK. Retrospective review of the frequency of ECG changes in hyperkalemia. Clin J Am Soc Nephrol. 2008 Mar; 3(2): 324-330. doi: 10.2215/CJN.04611007.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rhee CM. Serum potassium and the long interdialytic interval: minding the Gap. Am J Kidney Dis. 2017 Jul; 70(1): 4-7. doi: 10.1053/j.ajkd.2017.04.007.</mixed-citation><mixed-citation xml:lang="en">Rhee CM. Serum potassium and the long interdialytic interval: minding the Gap. Am J Kidney Dis. 2017 Jul; 70(1): 4-7. doi: 10.1053/j.ajkd.2017.04.007.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Орлов В.Н. Руководство по электрокардиографии. — 9-е изд., испр. — Москва: ООО «Медицинское информационное агентство». 2017; с. 535-543.</mixed-citation><mixed-citation xml:lang="en">Orlov V.N. Manual of electrocardiography. — 9-th. ed. — M: «Meditsinskoe informatsionnoe agentstvo» Ltd. 2017; p. 535-543. [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Korgaonkar S, Tilea A, Gillespie BW, et al. Serum potassium and outcomes in CKD: insights from the RRI-CKD cohort study. Clin J Am Soc Nephrol. 2010 May; 5(5): 762-769. doi: 10.2215/CJN.05850809.</mixed-citation><mixed-citation xml:lang="en">Korgaonkar S, Tilea A, Gillespie BW, et al. Serum potassium and outcomes in CKD: insights from the RRI-CKD cohort study. Clin J Am Soc Nephrol. 2010 May; 5(5): 762-769. doi: 10.2215/CJN.05850809.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hunter RW, Bailey MA. Hyperkalemia: pathophysiology, risk factors and consequences. Nephrol Dial Transplant. 2019 Dec 1; 34(Suppl 3): iii2-iii11. doi: 10.1093/ndt/gfz206.</mixed-citation><mixed-citation xml:lang="en">Hunter RW, Bailey MA. Hyperkalemia: pathophysiology, risk factors and consequences. Nephrol Dial Transplant. 2019 Dec 1; 34(Suppl 3): iii2-iii11. doi: 10.1093/ndt/gfz206.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Seliger SL. Hyperkalemia in patients with chronic renal failure. Nephrol Dial Transplant. 2019 Dec 1; 34(Suppl 3): iii12-iii18. doi: 10.1093/ndt/gfz231.</mixed-citation><mixed-citation xml:lang="en">Seliger SL. Hyperkalemia in patients with chronic renal failure. Nephrol Dial Transplant. 2019 Dec 1; 34(Suppl 3): iii12-iii18. doi: 10.1093/ndt/gfz231.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dépret F, Peacock WF, Liu KD, et al. Management of hyperkalemia in the acutely ill patient. Ann Intensive Care. 2019 Feb 28; 9(1): 32. doi: 10.1186/s13613-019-0509-8.</mixed-citation><mixed-citation xml:lang="en">Dépret F, Peacock WF, Liu KD, et al. Management of hyperkalemia in the acutely ill patient. Ann Intensive Care. 2019 Feb 28; 9(1): 32. doi: 10.1186/s13613-019-0509-8.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Clase CM, Carrero JJ, Ellison DH, et al. Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2020 Jan; 97(1): 42-61. doi: 10.1016/j.kint.2019.09.018.</mixed-citation><mixed-citation xml:lang="en">Clase CM, Carrero JJ, Ellison DH, et al. Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2020 Jan; 97(1): 42-61. doi: 10.1016/j.kint.2019.09.018.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
