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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2021-11-4-297-302</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-1274</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РАЗБОР КЛИНИЧЕСКИХ СЛУЧАЕВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANALYSIS OF CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Сочетание инфекционного эндокардита и инфекции COVID-19 у молодой пациентки</article-title><trans-title-group xml:lang="en"><trans-title>Combination of Infective Endocarditis and Covid-19 Infection in a Young Patient</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6187-7525</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономарева</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomareva</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии лечебного факультета</p><p>Саратов</p></bio><bio xml:lang="en"><p>Department of Hospital Therapy, Faculty of Medicine</p><p>Saratov</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5585-946X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кошелева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosheleva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Анатольевна Кошелева - кафедра госпитальной терапии лечебного факультета</p><p>Саратов</p></bio><bio xml:lang="en"><p>Natalia A. Kosheleva - Department of Hospital Therapy, Faculty of Medicine</p><p>Saratov</p></bio><email xlink:type="simple">kosheleva2009@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Саратовский ГМУ им. В.И. Разумовского» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University named after VI Razumovsky of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>12</day><month>08</month><year>2021</year></pub-date><volume>11</volume><issue>4</issue><fpage>297</fpage><lpage>302</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пономарева Е.Ю., Кошелева Н.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Пономарева Е.Ю., Кошелева Н.А.</copyright-holder><copyright-holder xml:lang="en">Ponomareva E.Y., Kosheleva N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/1274">https://www.medarhive.ru/jour/article/view/1274</self-uri><abstract><p>Инфекционный эндокардит нативного митрального клапана с множественными кардиоэмболическими инфарктами головного мозга и миокарда при сочетании с новой коронавирусной инфекцией тяжелого течения стал причиной неблагоприятного исхода у молодой женщины. Причинами этого стали как поздняя диагностика ИЭ (несвоевременное выполнение трансторакальной эхокардиографии), так и синергия патогенетических механизмов двух тяжелых заболеваний, наиболее ярко проявившаяся в развитии гемореологических нарушений, повреждении миокарда, легких и головного мозга.</p></abstract><trans-abstract xml:lang="en"><p>Infective endocarditis of the native mitral valve with multiple cardioembolic cerebral infarctions and myocardial infarctions against the background of a severe new coronavirus infection caused an unfavorable outcome in a young woman. The reasons for this were both the late diagnosis of IE (untimely performance of transthoracic echocardiography) and the synergy of the pathogenetic mechanisms of two serious diseases, which was most clearly manifested in the development of hemorheological disorders, damage to the myocardium, lungs and brain.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>SARS COV 2</kwd><kwd>COVID19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>infective endocarditis</kwd><kwd>new coronavirus infection</kwd><kwd>SARS COV 2</kwd><kwd>COVID19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fried JA, Ramasubbu К, Bhatt R, Topkara VK, Clerkin KJ, Horn Е et al. The Variety of Cardiovascular Presentations of COVID-19. Circulation. 2020;141 (23):1930-1936. 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