avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2021-11-6-424-432avk-1333Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESЭпигенетические механизмы кардиопротекции: в фокусе – активация сиртуиновEpigenetic Mechanisms of Cardioprotection: Focus is on Activation of SirtuinsАйтбаевК. А.AitbaevK. A.

Илхом Торобекович Муркамилов

Бишкек

Ilkhom T. Murkamilov

Bishkek

murkamilov.i@mail.ruМуркамиловИ. Т.MurkamilovI. T.

Бишкек

Bishkek

МуркамиловаЖ. А.MurkamilovaZh. A.

Бишкек

Bishkek

КудайбергеноваИ. О.KudaibergenovaI. O.

Бишкек

Bishkek

ЮсуповФ. А.YusupovF. A.

Ош

Osh

Научно-исследовательский институт молекулярной биологии и медициныКыргызстанScientific and research Institute of molecular biology and medicineKyrgyzstanКыргызская государственная медицинская академия имени И.К. Ахунбаева; ГОУ ВПО Кыргызско-Российский славянский университетКыргызстанI.K. Akhunbaev Kyrgyz State Medical Academy; SEI HPE Kyrgyz Russian Slavic UniversityKyrgyzstanГОУ ВПО Кыргызско-Российский славянский университетКыргызстанSEI HPE Kyrgyz Russian Slavic UniversityKyrgyzstanКыргызская государственная медицинская академия имени И.К. АхунбаеваКыргызстанI.K. Akhunbaev Kyrgyz State Medical AcademyKyrgyzstanОшский государственный университетКыргызстанOsh State UniversityKyrgyzstan202128112021116424432Copyright © Айтбаев К.А., Муркамилов И.Т., Муркамилова Ж.А., Кудайбергенова И.О., Юсупов Ф.А., 20212021Айтбаев К.А., Муркамилов И.Т., Муркамилова Ж.А., Кудайбергенова И.О., Юсупов Ф.А.Aitbaev K.A., Murkamilov I.T., Murkamilova Z.A., Kudaibergenova I.O., Yusupov F.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/1333

Окислительный стресс является общим признаком старения и сердечно-сосудистых заболеваний (ССЗ), включая атеросклероз, сердечную недостаточность, гипертонию, сахарный диабет и другие заболевания сосудистой системы. В этой связи, в последние годы исследователи проявляют повышенный интерес к сиртуинам (SIRT) — адаптерам стресса и эпигенетическим ферментам, участвующим в клеточных механизмах контроля возрастных патологий, рака и ССЗ. Среди сиртуинов, которых у млекопитающих семь (SIRT1-SIRT7), кардиопротекторными, противовоспалительными, атеропротекторными и антивозрастными свойствами в наибольшей степени обладают SIRT1 и SIRT6. В данном обзоре мы представляем всесторонний анализ последних событий в области клеточных и молекулярных сигнальных путей, контролируемых двумя посттрансляционными модификаторами — SIRT1 и SIRT6, которые доказали свою ценность в качестве инструментов для ослабления воспаления и окислительного стресса на уровне сердечно-сосудистой системы. Более глубокое понимание эпигенетических механизмов, через которые оказывают своё кардиопротекторное действие SIRT1 и SIRT6, будет иметь широкие последствия и ускорит разработку селективных и эффективных фармакологических препаратов для модуляции сиртуинов с целью профилактики и лечения ССЗ.

Oxidative stress is a common sign of aging and cardiovascular disease (CVD), including atherosclerosis, heart failure, hypertension, diabetes mellitus and other diseases of the vascular system. In this regard, in recent years, researchers have shown increased interest in sirtuins (SIRTs) — stress adapters and epigenetic enzymes involved in cellular mechanisms for controlling age-related pathologies, cancer and CVD. Among sirtuins, of which there are seven in mammals (SIRT1-SIRT7), SIRT1 and SIRT6 possess the most cardioprotective, anti-inflammatory, atheroprotective and anti-aging properties. In this review, we present a comprehensive analysis of the latest developments in the field of cellular and molecular signaling pathways controlled by two post-translational modifiers — SIRT1 and SIRT6, which have proven their worth as tools to reduce inflammation and oxidative stress at the level of the cardiovascular system. A deeper understanding of the epigenetic mechanisms through which SIRT1 and SIRT6 exert their cardioprotective effect will have widespread implications and will accelerate the development of selective and effective pharmacological agents for modulating sirtuins for the prevention and treatment of CVD.

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The authors declare that there are no conflicts of interest present.