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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2022-12-5-330-340</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-1505</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>КОНСЕНСУС ЕВРОПЕЙСКИХ ЭКСПЕРТОВ ПО ВЕДЕНИЮ ПАЦИЕНТОВ С ИШЕМИЕЙ С НЕОБСТРУКТИВНЫМ ПОРАЖЕНИЕМ КОРОНАРНЫХ АРТЕРИЙ ПРИ ХРОНИЧЕСКОМ КОРОНАРНОМ СИНДРОМЕ: ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ В АМБУЛАТОРНОЙ КЛИНИЧЕСКОЙ ПРАКТИКЕ В РОССИИ</article-title><trans-title-group xml:lang="en"><trans-title>Consensus of European Experts on the Management of Patients with Ischemia with Non-Obstructive Coronary Arteries with Chronic Coronary Syndrome: Possibilities for Use in Outpatient Clinical Practice in Russia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7825-5597</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ларина</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Larina</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вера Николаевна Ларина</p><p>Москва</p></bio><bio xml:lang="en"><p>Vera N. Larina</p><p>Moscow</p></bio><email xlink:type="simple">larinav@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1011-8323</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корчагин</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Korchagin</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России; ФГБНУ «Научно-исследовательский институт медицины труда имени академика Н.Ф. Измерова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University; Federal State Budgetary Scientific Institution «Izmerov Research Institute of Occupational Health»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2022</year></pub-date><volume>12</volume><issue>5</issue><fpage>330</fpage><lpage>340</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ларина В.Н., Корчагин И.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ларина В.Н., Корчагин И.А.</copyright-holder><copyright-holder xml:lang="en">Larina V.N., Korchagin I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/1505">https://www.medarhive.ru/jour/article/view/1505</self-uri><abstract><p>В 2020 г вышел консенсусный документ Европейского общество кардиологов по ведению пациентов с ишемией миокарда, связанной с необструктивным поражением коронарных артерий. Основные положения нового документа ориентированы на выделение особой группы пациентов с хроническим коронарным синдромом и подозрением на вазоспастическую или микрососудистую стенокардию с целью рационализации и персонификации подхода к их ведению. Большая часть пациентов с установленной ишемией, при прохождении коронарной ангиографии не имеет гемодинамически значимой обструкции коронарных артерий. Коронарная микрососудистая дисфункция и эпикардиальный вазоспазм, отдельно или в сочетании с атеросклеротическим поражением коронарных артерий сердца, являются причинами ишемии миокарда. При этом микроваскулярная дисфункция рассматривается в качестве значимого провоцирующего фактора развития рефрактерной стенокардии. Диагностика подобных состояний нередко затруднена, и поэтому для таких пациентов не назначается оптимальная терапия. Как следствие, эти пациенты имеют низкое качество жизни, что приводит к повторным госпитализациям, неблагоприятным сердечно-сосудистым исходам в краткосрочной и долгосрочной перспективе и значительной нагрузке на ресурсы здравоохранения. В статье рассматриваются возможности применения новых рекомендаций и консенсуса в диагностике и ведении таких пациентов в условиях амбулаторной клинической практики в России. На начальных этапах диагностики приоритет отдается неинвазивным методам исследования, для детального обследования проводится инвазивное обследование с фармакологической нагрузкой. При ведении пациентов используется пошаговая стратегия в зависимости от конкретной клинической ситуации. Препаратами первой линии антиишемической терапии остаются блокаторы кальциевых каналов или бета-блокаторы.</p></abstract><trans-abstract xml:lang="en"><p>In 2020, a consensus document of the European Society of Cardiology on the management of patients with myocardial ischemia with non-obstructive coronary arteries was released. The main provisions of the new document are aimed at identifying a special group of patients with chronic coronary syndrome and suspected vasospastic or microvascular angina in order to rationalize and personalize the approach to their management. Most patients with established myocardial ischemia do not have obstructive coronary arteries when undergoing coronary angiography. Coronary microvascular dysfunction and epicardial vasospasm, alone or in combination with obstructive coronary artery atherosclerosis, are the causes of myocardial ischemia. In this case, microvascular dysfunction is considered as a significant provoking factor in the pathogenesis of refractory angina pectoris. Diagnosis of such conditions is often difficult, and therefore the correct therapy is not prescribed for such patients. As a consequence, these patients have a poor quality of life, which leads to hospital readmissions, poor cardiovascular outcomes in the short and long term, and a significant burden on health care resources. The article discusses the possibilities of applying new recommendations and consensus in the diagnosis and management of such patients in outpatient clinical practice in Russia. At the initial stages of diagnosis, priority is given to non-invasive research methods; in-depth examination, carried out using invasive methods with a pharmacological testing. Patient management uses a stepwise strategy depending on the specific clinical situation. Calcium channel blockers or beta blockers remain the first line anti-ischemic therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хронический коронарный синдром</kwd><kwd>вазоспастическая стенокардия</kwd><kwd>ишемия</kwd><kwd>микрососудистая дисфункция</kwd><kwd>рефрактерная стенокардия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic coronary syndrome</kwd><kwd>vasospastic angina</kwd><kwd>ischemia</kwd><kwd>microvascular dysfunction</kwd><kwd>refractory angina</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Knuuti J., Wijns W., Saraste A. et al. ESC Scientific Document Group, 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC). 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