avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2022-12-6-405-421avk-1530Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESКАНАЛЬЦЕВЫЙ АППАРАТ ПОЧЕК — НАУЧНОЕ И ПРИКЛАДНОЕ ЗНАЧЕНИЕKidney Tubules — Scientific and Applied Valuehttps://orcid.org/0000-0001-6165-3943ЛевицкаяЕ. С.LevitskayaE. S

Екатерина Сергеевна Левицкая

Ростов-на-Дону

Ekaterina S. Levitskaya

Rostov-on-Don

es.med@mai.ruБатюшинМ. М.BatiushinM. M.

Ростов-на-Дону

Rostov-on-Don

Федеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра внутренних болезней № 2РоссияFederal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Healthcare of the Russian Federation, Department of Internal Dis-eases № 2Russian Federation202229112022126405421Copyright © Левицкая Е.С., Батюшин М.М., 20222022Левицкая Е.С., Батюшин М.М.Levitskaya E.s., Batiushin M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/1530

 

В настоящее время существует высокий научный интерес к изучению особенностей структуры и функций канальцев почек. Актуальность темы обусловлена потенциальной возможностью выявления разнообразных маркеров нарушения функции канальцев и использования их для ранней диагностики не только тубулопатий, но и гломерулярных нарушений. В клинической практике маркеры канальцевой дисфункции используются недостаточно. В статье представлены сведения об анатомо-функциональных особенностях проксимального и дистального отделов канальцевого аппарата, изложены высокоорганизованные механизмы межмолекулярного взаимодействия, представлены основные биологически активные вещества, изменение концентрации которых является следствием повреждения канальцев. Представленная рукопись является продуктом глубокого анализа и систематизации имеющихся данных в российских и зарубежных информационно-аналитических порталах.

Currently, there is a high scientific interest in studying the features of the structure and functions of the tubules of the kidneys. The relevance of the topic is due to the potential possibility of identifying various markers of tubular dysfunction and using them for early diagnosis of not only tubulopathies, but also glomerular disorders. In clinical practice, markers of tubular dysfunction are used insufficiently. The article presents information about the anatomical and functional features of the proximal and distal parts of the tubular apparatus, outlines highly organized mechanisms of intermolecular interaction, presents the main biologically active substances, the change in the concentration of which is a consequence of damage to the tubules. The presented manuscript is the product of a deep analysis and systematization of the available data in Russian and foreign information and analytical portals.

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The authors declare that there are no conflicts of interest present.