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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2022-12-6-473-480</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-1537</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РАЗБОР КЛИНИЧЕСКИХ СЛУЧАЕВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANALYSIS OF CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИЙ СЛУЧАЙ ГЕНЕРАЛИЗОВАННОГО САРКОИДОЗА С ПРЕИМУЩЕСТВЕННЫМ ПОРАЖЕНИЕМ СПИННОГО МОЗГА</article-title><trans-title-group xml:lang="en"><trans-title>A Clinical Case of Generalized Sarcoidosis with a Predominant Lesion of the Spinal Cord</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2045-9607</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черников</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernikov</surname><given-names>A. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Юрьевич Черников</p><p>Курск</p></bio><bio xml:lang="en"><p>Alexander Y. Chernikov</p><p>Kursk</p></bio><email xlink:type="simple">ale-cherny@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кабанова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kabanova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Курск</p></bio><bio xml:lang="en"><p>Kursk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дьяков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyakov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Курск</p></bio><bio xml:lang="en"><p>Kursk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра клинической иммунологии, аллергологии и фтизиопульмонологии ФГБОУ ВО Курский государственный медицинский университет Минздрава РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Department of Clinical Immunology, Allergology and Phthisiopulmonology, Kursk State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>01</day><month>12</month><year>2022</year></pub-date><volume>12</volume><issue>6</issue><fpage>473</fpage><lpage>480</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черников А.Ю., Кабанова С.А., Дьяков А.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Черников А.Ю., Кабанова С.А., Дьяков А.В.</copyright-holder><copyright-holder xml:lang="en">Chernikov A.Y., Kabanova S.A., Dyakov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/1537">https://www.medarhive.ru/jour/article/view/1537</self-uri><abstract><p>Саркоидоз, как системный эпителиоидно-клеточный гранулематоз, может сопровождаться поражением не только внутригрудных лимфатических узлов и лёгких, но и других органов, в частности, центральной нервной системы и периферических лимфатических узлов. В спектре экстраторакальных поражений саркоидоз спинного мозга встречается лишь в 6-8 % случаев всех поражений мозга. Представленный клинический пример иллюстрирует поражение спинного мозга на уровне грудного отдела, хотя в литературе чаще описывается поражение шейного отдела. Заболевание сопровождалось саркоидозом внутригрудных лимфатических узлов с быстрой спонтанной регрессией и саркоидозом надключичного лимфатического узла. Диагноз был подтвержден после биопсии периферического лимфоузла. Саркоидоз спинного мозга у данного пациента характеризовался быстрой регрессией на фоне парентерального введения дексаметазона в течение 14 дней с последующим переводом на таблетированные формы преднизолона. Положительная динамика саркоидоза спинного мозга опровергла предположение о наличии саркоидной реакции в лимфатических узлах на фоне опухоли спинного мозга. Использование курса реабилитационных методик способствовало восстановлению работоспособности.</p></abstract><trans-abstract xml:lang="en"><p>Sarcoidosis, as systemic epithelioid cell granulomatosis, can be accompanied by damage not only to the intrathoracic lymph nodes and lungs, but also to other organs, in particular, the central nervous system and peripheral lymph nodes. In the spectrum of extrathoracic lesions, spinal cord sarcoidosis occurs only in 6-8 % of cases of all brain lesions. The presented clinical example illustrates the lesion of the spinal cord at the level of the thoracic region, although the literature more often describes the lesion of the cervical region. The disease was accompanied by sarcoidosis of the intrathoracic lymph nodes with rapid spontaneous regression and sarcoidosis of the supraclavicular lymph node. The diagnosis was confirmed after a peripheral lymph node biopsy. Spinal cord sarcoidosis in this patient was characterized by rapid regression against the background of parenteral administration of dexamethasone for 14 days, followed by transfer to tablet forms of prednisone. The positive dynamics of spinal cord sarcoidosis refuted the assumption of the presence of a sarcoid reaction in the lymph nodes against the background of a spinal cord tumor. The use of a course of rehabilitation techniques contributed to the recovery of working capacity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>генерализованный саркоидоз</kwd><kwd>саркоидоз спинного мозга</kwd><kwd>саркоидоз центральной нервной системы</kwd><kwd>реабилитация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>генерализованный саркоидоз</kwd><kwd>саркоидоз спинного мозга</kwd><kwd>саркоидоз центральной нервной системы</kwd><kwd>реабилитация</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Министерство здравоохранения Российской Федерации. Клинические рекомендации Саркоидоз. Российское респираторное общество, Общероссийское Педиатрическое респираторное общество, Российское научное общество терапевтов. М.: 2019. 47 с.</mixed-citation><mixed-citation xml:lang="en">The Ministry of Health of the Russian Federation. Clinical recommendations of Sarcoidosis. 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JAMA Neurol. 2018; 75(12): 1546-1553. doi:10.1001/jamaneurol.2018.2295.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
