avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2023-13-1-5-13avk-1558Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESУРОМОДУЛИН — БИОЛОГИЧЕСКАЯ ЗНАЧИМОСТЬ И ПЕРСПЕКТИВА КЛИНИЧЕСКОГО ПРИМЕНЕНИЯUromodulin — Biological Significance and Prospects for Clinical Usehttps://orcid.org/0000-0001-6165-3943ЛевицкаяЕ. С.LevitskayaE. S.

Екатерина Сергеевна Левицкая

Ростов-на-Дону

Ekaterina S. Levitskaya

Rostov-on-Don

es.med@mai.ruhttps://orcid.org/0000-0002-2733-4524БатюшинМ. М.BatiushinM. M.

Ростов-на-Дону

Rostov-on-Don

https://orcid.org/0000-0001-5856-0404ГасановМ. З.GasanovM. Z.

Ростов-на-Дону

Rostov-on-Don

Федеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации, кафедра внутренних болезней № 2РоссияFederal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Healthcare of the Russian Federation, Department of Internal Diseases № 2Russian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской Федерации кафедра внутренних болезней № 1РоссияFederal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Healthcare of the Russian Federation, Department of Internal Diseases № 1Russian Federation202325012023131513Copyright © Левицкая Е.С., Батюшин М.М., Гасанов М.З., 20232023Левицкая Е.С., Батюшин М.М., Гасанов М.З.Levitskaya E.S., Batiushin M.M., Gasanov M.Z.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/1558

 

Уромодулин является уникальным белком, вырабатываемым в почках клетками эпителия восходящей толстой части петли Генле. Он реализует физиологические механизмы не только на канальцевом уровне, но и участвует в координации общеорганизменных процессов. Основными функциями уромодулина являются: препятствие камнеобразованию за счет нарушения агрегации солей кальция и реабсорбции воды, координация электролитного баланса, препятствие воспалительным процессам локально и системно. Экспрессия уромодулина и его качественные характеристики находятся под генетическим контролем. В связи с этим патология канальцевого аппарата или мутации генов, кодирующих уромодулин, приводят к развитию первичных или вторичных тубулопатий с дисфункцией других органов и систем. Вместе с тем известно, что уромодулин является не полностью изученным белком как по структуре, так и по особенностям выполняемых им функций. Проведен анализ научно-исследовательских сведений, в том числе экспериментальных работ по изучению уромодулина в отечественных и международных источниках литературы, с изложением полученного материла в данной рукописи.

Uromodulin is a unique protein produced in the kidneys by epithelial cells of the ascending thick portion of the loop of Henle. It implements physiological mechanisms not only at the tubular level, but also participates in the coordination of general body processes. The main functions of uromodulin are an obstacle to prevent stone formation due to a violation of the aggregation of calcium salts and water reabsorption, coordination of electrolyte balance, and an obstacle to inflammatory processes locally and systemically. Moreover, the expression of uromodulin and its qualitative characteristics are under genetic control. In this regard, the pathology of the tubular apparatus or mutations in the genes encoding uromodulin lead to the development of primary or secondary tubulopathies with dysfunction of other organs and systems. At the same time, it is known that uromodulin is an incompletely studied protein both in terms of structure and features of the functions it performs. A thorough analysis of research data, including experimental work on the study of uromodulin in domestic and international literature sources, was carried out, with a presentation of the material in this manuscript.

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The authors declare that there are no conflicts of interest present.