avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2023-13-2-129-135avk-1595Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLEСахароснижающая терапия и течение постковидного синдрома, есть ли связь?Hypoglycemic Therapy and the Course of Post-Covid Syndrome, is There a Connection?https://orcid.org/0000-0003-3611-1186ИгнатенкоГ. А.IgnatenkoG. A.

Донецк, ДНР

Donetsk, DPR

https://orcid.org/0000-0003-2592-0906БагрийА. Э.BagriyA. E.

Донецк, ДНР

Donetsk, DPR

https://orcid.org/0000-0002-2127-6925ПриколотаО. А.PrikolotaO. A.

Донецк, ДНР

Donetsk, DPR

https://orcid.org/0000-0002-9128-2511ПриколотаА. В.PrikolotaA. V.

Донецк, ДНР

Donetsk, DPR

https://orcid.org/0000-0002-1912-5052МогилевскаяК. Э.MogilevskayaK. E.

Кристина Элмурадовна Могилевская

Донецк, ДНР

Kristina E. Mogilevskaya

Donetsk, DPR

dzkristi@yandex.comГосударственная образовательная организация высшего профессионального образования «Донецкий национальный медицинский университет им. М. Горького»РоссияState educational organization of higher professional education «m. Gorky Donetsk national medical university»Russian Federation202305042023132129135Copyright © Игнатенко Г.А., Багрий А.Э., Приколота О.А., Приколота А.В., Могилевская К.Э., 20232023Игнатенко Г.А., Багрий А.Э., Приколота О.А., Приколота А.В., Могилевская К.Э.Ignatenko G.A., Bagriy A.E., Prikolota O.A., Prikolota A.V., Mogilevskaya K.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/1595

Сахарный диабет (как 1, так и 2 типа) считается одним из факторов риска тяжелого течения COVID-19 и смерти от этой инфекции. Перенесенная инфекция COVID-19 приводит к ухудшению контроля уже имеющегося сахарного диабета, прогрессированию предиабета в диабет, увеличению числа новых случаев диабета и росту удельного веса глюкокортикоид-индуцированного диабета, что значительно усугубляет течение постковидного синдрома для данной категории пациентов. Сахароснижающие препараты могут влиять на патогенез COVID-19, что может иметь значение для лечения пациентов с сахарным диабетом 2 типа и постковидным синдромом. В обзоре также представлены собственные данные о влиянии на постковидный синдром различных режимов приема пероральных сахароснижающих средств у лиц с сахарным диабетом 2 типа. Наблюдение показало, что использование ингибиторов дипептидилпептидазы-4 в составе лечебной стратегии у пациентов с сахарным диабетом 2 типа с перенесенной инфекцией COVID-19 ассоциировалось с уменьшением продолжительности и выраженности проявлений постковидного синдрома.

Diabetes mellitus (both type 1 and type 2) is considered one of the risk factors for severe COVID-19 and death from this infection. Past infection with COVID-19 leads to deterioration in the control of existing diabetes mellitus, progression of pre-diabetes to diabetes, an increase in the number of new cases of diabetes and an increase in the proportion of glucocorticoid-induced diabetes, which significantly aggravates the course of post-COVID syndrome for this category of patients. Antihyperglycemic drugs may influence the pathogenesis of COVID-19, which may be of relevance for the treatment of patients with type 2 diabetes mellitus and post-COVID syndrome. The review also presents our own data on the effect of various regimens of oral hypoglycemic agents on post-COVID syndrome in people with type 2 diabetes mellitus. The observation showed that the use of dipeptidyl peptidase-4 inhibitors as part of a treatment strategy in patients with type 2 diabetes mellitus with a past COVID-19 infection was associated with a decrease in the duration and severity of post-COVID symptoms.

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The authors declare that there are no conflicts of interest present.