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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2023-13-2-144-154</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-1597</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РАЗБОР КЛИНИЧЕСКИХ СЛУЧАЕВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANALYSIS OF CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Драматический исход поздней диагностики хронического аутоиммунного тиреоидита с первичным гипотиреозом тяжелой степени</article-title><trans-title-group xml:lang="en"><trans-title>The Dramatic Outcome of the Late Diagnosis of the Chronic Autoimmune Thyroiditis with the Severe Primary Hypothyroidism</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7479-418X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Резник</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Reznik</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Владимировна Резник</p><p>кафедра пропедевтики внутренних болезней лечебного факультета</p><p>Москва</p></bio><bio xml:lang="en"><p>Elena V. Reznik</p><p>the Department of Propedeutics of Internal disease of the medical faculty</p><p>Moscow</p></bio><email xlink:type="simple">elenaresnik@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2321-9561</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Годило-Годлевский</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Godilo-Godlevsky</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра пропедевтики внутренних болезней лечебного факультета</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0932-3987</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайнуллина</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaynullina</surname><given-names>Y. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра пропедевтики внутренних болезней лечебного факультета</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2052-914X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михалёва</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhaleva</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8937-9293</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6068-7009</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васюкова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasyukova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0161-005X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голухов</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Golukhov</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России; ГБУЗ «ГКБ № 31» ДЗМ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation; City Clinical Hospital № 31</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «ГКБ № 31» ДЗМ; ФГБНУ Научно-исследовательский институт морфологии человека</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital № 31; Federal State Scientific Institution Research Institute of Human Morphology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ «ГКБ № 31» ДЗМ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital № 31</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>05</day><month>04</month><year>2023</year></pub-date><volume>13</volume><issue>2</issue><fpage>144</fpage><lpage>154</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Резник Е.В., Годило-Годлевский В.А., Зайнуллина Ю.И., Михалёва Л.М., Смирнова И.В., Васюкова О.А., Голухов Г.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Резник Е.В., Годило-Годлевский В.А., Зайнуллина Ю.И., Михалёва Л.М., Смирнова И.В., Васюкова О.А., Голухов Г.Н.</copyright-holder><copyright-holder xml:lang="en">Reznik E.V., Godilo-Godlevsky V.A., Zaynullina Y.I., Mikhaleva L.M., Smirnova I.V., Vasyukova O.A., Golukhov G.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/1597">https://www.medarhive.ru/jour/article/view/1597</self-uri><abstract><p>Статья посвящена разбору клинического случая поздней диагностики тяжелого гипотиреоза. Приведен обзор так называемых «клинических масок» гипотиреоза, затрудняющих диагностику. Акцентируется внимание на необходимости своевременного включения в план комплексного обследования коморбидных пациентов анализов уровня тиреотропного гормона гипофиза и гормонов щитовидной железы. Показано, что несвоевременное начало заместительной терапии гипотиреоза ассоциировано с плохим прогнозом.</p></abstract><trans-abstract xml:lang="en"><p>The article is devoted to the analysis of a clinical case of the severe hypothyroidism. A review of the “clinical masks” of the hypothyroidism is presented. The examination of the polymorbid patients should include the level of thyroid-stimulating hormone and thyroid hormones. The untimely initiation of substitution therapy is associated with a poor prognosis, and the early start of the treatment is a guarantee of saving the life of a patient with severe hypothyroidism.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипотиреоз</kwd><kwd>хронический аутоиммунный тиреоидит</kwd><kwd>тиреотропный гормон</kwd><kwd>полисерозит</kwd><kwd>кишечная непроходимость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypothyroidism</kwd><kwd>chronic autoimmune thyroiditis</kwd><kwd>thyroid-stimulating hormone</kwd><kwd>polyserositis</kwd><kwd>intestinal obstruction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Новиков В.И., Новиков К.Ю. Междисциплинарные аспекты синдрома гипотиреоза: диагностика и лечение. Эффективная фармакотерапия. 2014; 46: 50-55.</mixed-citation><mixed-citation xml:lang="en">Novikov V.I., Novikov K.YU. 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