avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2023-13-3-175-180FEKKPEavk-1612Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESЛЕКАРСТВЕННО-ИНДУЦИРОВАННАЯ ГОЛОВНАЯ БОЛЬ (ОБЗОР ЛИТЕРАТУРЫ И РЕКОМЕНДАЦИИ ДЛЯ ПРАКТИКИ)Medication-Overuse Headache (Review of Literature and Recommendations for Practice)СтариковаН. Л.StarikovaN. L.

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ФГБОУ ВО Пермский государственный медицинский университет им. ак. Е.А. Вагнера МЗ РФРоссияThe Neurology Department of E.A. Vagner Perm State Medical UniversityRussian Federation202307062023133175180Copyright © Старикова Н.Л., 20232023Старикова Н.Л.Starikova N.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/1612

Лекарственно-индуцированная головная боль (ЛИГБ) является распространенной вторичной цефалгией, развивающейся у пациентов с частыми и хроническими головными болями при злоупотреблении анальгетическими препаратами и приводящей к значительному ухудшению качества жизни пациентов. Терапия ЛИГБ требует высокой степени комплаентности в отношениях врач-пациент и не всегда приводит к удовлетворительному результату. Поэтому важной задачей является профилактика излишне частого применения симптоматических средств для купирования головной боли. В обзоре представлены современные данные о ЛИГБ, ее лечении и профилактике.

Medication-overuse headache (MOH) is a highly prevalent secondary headache, developing in patients with frequent and chronic cephalalgias due to excessive use of “acute” medications for headache, and significantly affecting patients’ quality of life. Treatment of MOH demands high compliance physician-patient, and the result is satisfactory not in all cases. For this reason, the prophylaxis of overuse of symptomatic medications for headaches is important. The review presents contemporary data on MOH, its treatment and prophylaxis.

лекарственно-индуцированная головная больанальгетические препаратылечениепрофилактикаmedication-overuse headacheanalgesic medicationstreatmentprophylaxisReferencesPeters GL. Migraine overview and summary of current and emerging treatment options. Am J Manag Care 2019;25(2 Suppl):s23-s34Peters GL. Migraine overview and summary of current and emerging treatment options. Am J Manag Care 2019;25(2 Suppl):s23-s34Stovner L, Hagen K, Jensen R, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalagia 2007; 27(3): 193–210. https://doi.org/10.1111/j.1468-2982.2007.01288.xStovner L, Hagen K, Jensen R, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalagia 2007; 27(3): 193–210. https://doi.org/10.1111/j.1468-2982.2007.01288.xThe International Classification of headache disorders, 3rd edition. Cephalalgia 2018; 38(1): 1-211. doi: 10.1177/0333102417738202The International Classification of headache disorders, 3rd edition. Cephalalgia 2018; 38(1): 1-211. doi: 10.1177/0333102417738202Westergaard ML, Munksgaard SB, Bendtsen L, et al. Medicationoveruse headache: a perspective review. Ther Adv Drug Saf 2016; 7(4): 147-158. doi: 10.1177/2042098616653390Westergaard ML, Munksgaard SB, Bendtsen L, et al. Medicationoveruse headache: a perspective review. Ther Adv Drug Saf 2016; 7(4): 147-158. doi: 10.1177/2042098616653390Diener H-C, Holle D, Solbach K, et al. Nat Rev Neurol 2016; 12(10): 575-583. https://doi.org/10.1038/nrneurol.2016.124Diener H-C, Holle D, Solbach K, et al. Nat Rev Neurol 2016; 12(10): 575-583. https://doi.org/10.1038/nrneurol.2016.124Diener H-C, Holle D, Dresler T, et al. Chronic headache due to overuse of analgesics and anti-migraine agents. Dtsch Arztebl Int 2018; 115(22): 365-370. https://doi.org/10.3238/arztebl.2018.0365Diener H-C, Holle D, Dresler T, et al. Chronic headache due to overuse of analgesics and anti-migraine agents. Dtsch Arztebl Int 2018; 115(22): 365-370. https://doi.org/10.3238/arztebl.2018.0365Carlsen LN, Westergaard ML, Bisgaard M, et al. National awareness campaign to prevent medication-overuse headache in Denmark. Cephalalgia 2018; 38(7): 1316-1325. https://doi.org/10.1177/0333102417736898Carlsen LN, Westergaard ML, Bisgaard M, et al. National awareness campaign to prevent medication-overuse headache in Denmark. Cephalalgia 2018; 38(7): 1316-1325. https://doi.org/10.1177/0333102417736898Salhofer-Polanyi S, Zebenholzer K, Berndl T et al. Medication overuse headache in 787 patients admitted for inpatient treatment over a period of 32 years. Cephalalgia 2020; 40(8): 808-817. doi: 10.1177/0333102420911210Salhofer-Polanyi S, Zebenholzer K, Berndl T et al. Medication overuse headache in 787 patients admitted for inpatient treatment over a period of 32 years. Cephalalgia 2020; 40(8): 808-817. doi: 10.1177/0333102420911210Holland PR, Saenjaroentham C, Sureda-Gibert P, et al. Medicationoveruse headache: Divergent effects of new acute antimigraine drugs. Cephalalgia 2020; 40(9): 889-891. doi: 10.1177/0333102420938655Holland PR, Saenjaroentham C, Sureda-Gibert P, et al. Medicationoveruse headache: Divergent effects of new acute antimigraine drugs. Cephalalgia 2020; 40(9): 889-891. doi: 10.1177/0333102420938655Wakerley BR. Medication-overuse headache. Pract Neurol 2019; 19(5): 399-403. https://doi.org/10.1136/practneurol-2018-002048Wakerley BR. Medication-overuse headache. Pract Neurol 2019; 19(5): 399-403. https://doi.org/10.1136/practneurol-2018-002048Takahashi TT, Ornello R, Quatrosi G et al. Medication overuse and drug addiction: a narrative review from addiction perspective. J Headache Pain 2021; 22: 32. https://doi.org/10.1186/s10194-021-01224-8Takahashi TT, Ornello R, Quatrosi G et al. Medication overuse and drug addiction: a narrative review from addiction perspective. J Headache Pain 2021; 22: 32. https://doi.org/10.1186/s10194-021-01224-8Cargnin S, Viana M, Sances G et al. A systematic review and critical appraisal of gene polymorphism association studies in medication-overuse headache. Cephalalgia 2018; 38(7): 1361-1373. https://doi.org/10.1177/0333102417728244Cargnin S, Viana M, Sances G et al. A systematic review and critical appraisal of gene polymorphism association studies in medication-overuse headache. Cephalalgia 2018; 38(7): 1361-1373. https://doi.org/10.1177/0333102417728244Dodick DW, Silberstein SD. How clinicians can detect, prevent and treat medication overuse headache. Cephalalgia 2008; 28(11): 1107-1242. https://doi.org/10.1111/j.1468-2982.2008.01737.xDodick DW, Silberstein SD. How clinicians can detect, prevent and treat medication overuse headache. Cephalalgia 2008; 28(11): 1107-1242. https://doi.org/10.1111/j.1468-2982.2008.01737.xNation KM, Dodick DW, Navratilova E, et al. Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache. Cephalalgia 2019; 39(5): 617-525. https://doi.org/10.1177/0333102418804157Nation KM, Dodick DW, Navratilova E, et al. Sustained exposure to acute migraine medications combined with repeated noxious stimulation dysregulates descending pain modulatory circuits: Relevance to medication overuse headache. Cephalalgia 2019; 39(5): 617-525. https://doi.org/10.1177/0333102418804157Su M, Yu S. Chronic migraine: A process of dysmodulation and sensitization. Molecular Pain. 2018; 14. doi:10.1177/1744806918767697Su M, Yu S. Chronic migraine: A process of dysmodulation and sensitization. Molecular Pain. 2018; 14. doi:10.1177/1744806918767697Chanraud S, Di Scala G, Dilharreguy B, et al. Brain functional connectivity and morphology changes in medication-overuse headache: Clue for dependence-related processes? Cephalalgia 2014; 34(8): 563-639. https://doi.org/10.1177/0333102413519514Chanraud S, Di Scala G, Dilharreguy B, et al. Brain functional connectivity and morphology changes in medication-overuse headache: Clue for dependence-related processes? Cephalalgia 2014; 34(8): 563-639. https://doi.org/10.1177/0333102413519514Galvez-Sánchez CM, Montoro CI, Moreno-Padilla M, et al. Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: a systematic review. J Clin Med 2021; 10: 2706. https://doi.org/10.3390/jcm10122706Galvez-Sánchez CM, Montoro CI, Moreno-Padilla M, et al. Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: a systematic review. J Clin Med 2021; 10: 2706. https://doi.org/10.3390/jcm10122706Chiang C-C, Schwedt TJ, Wang S-J, et al. Treatment of medicationoveruse headache: A systematic review. Cephalalgia 2016; 36(4): 371-386. doi: 10.1177/0333102415593088Chiang C-C, Schwedt TJ, Wang S-J, et al. Treatment of medicationoveruse headache: A systematic review. Cephalalgia 2016; 36(4): 371-386. doi: 10.1177/0333102415593088Riederer F, Marti M, Luechinger R et al. Grey matter changes associated with medication-overuse headache: correlations with disease related disability and anxiety. World J Biol Psychiatry 2012; 13(7): 517-525. https://doi.org/10.3109/15622975.2012.665175Riederer F, Marti M, Luechinger R et al. Grey matter changes associated with medication-overuse headache: correlations with disease related disability and anxiety. World J Biol Psychiatry 2012; 13(7): 517-525. https://doi.org/10.3109/15622975.2012.665175Lai T-H, Chou K-H, Fuh J-L, et al. Gray matter changes related to medication overuse in patients with chronic migraine. Cephalalgia 2016; 36(14): 1305-1398. https://doi.org/10.1177/0333102416630593Lai T-H, Chou K-H, Fuh J-L, et al. Gray matter changes related to medication overuse in patients with chronic migraine. Cephalalgia 2016; 36(14): 1305-1398. https://doi.org/10.1177/0333102416630593Stankewitz A, Schulz E, May A. Neuronal correlates of impaired habituation in response to repeated trigemino-nociceptive but not to olfactory input in migraneurs: an fMRI study. Cephalalgia 2012; 33(4): 256-265. doi: 10.1177/0333102412470215Stankewitz A, Schulz E, May A. Neuronal correlates of impaired habituation in response to repeated trigemino-nociceptive but not to olfactory input in migraneurs: an fMRI study. Cephalalgia 2012; 33(4): 256-265. doi: 10.1177/0333102412470215Niddam DM, Lai K-L, Tsai S-Y et al. Brain metabolites in chronic migraine patients with medication overuse headache. Cephalalgia 2020; 40(8): 851-862. https://doi.org/10.1177/0333102420908579Niddam DM, Lai K-L, Tsai S-Y et al. Brain metabolites in chronic migraine patients with medication overuse headache. Cephalalgia 2020; 40(8): 851-862. https://doi.org/10.1177/0333102420908579Viana M, Bottiroli S, Sances G, et al. Factors associated to chronic migraine with medication overuse: A crosssectional study. Cephalalgia 2018; 38(14): 2045-2057. doi: 10.1177/0333102418761047Viana M, Bottiroli S, Sances G, et al. Factors associated to chronic migraine with medication overuse: A crosssectional study. Cephalalgia 2018; 38(14): 2045-2057. doi: 10.1177/0333102418761047Hagen K, Linde M, Steiner TJ et al. Risk factors for medicationoveruse headache: An 11-year follow-up study. The Nord-Trondelag Health Studies. Pain 2012; 153: 56-61. https://doi.org/10.1016/j.pain.2011.08.018Hagen K, Linde M, Steiner TJ et al. Risk factors for medicationoveruse headache: An 11-year follow-up study. The Nord-Trondelag Health Studies. Pain 2012; 153: 56-61. https://doi.org/10.1016/j.pain.2011.08.018Lampl C, Thomas H, Tassorelli C, et al. Headache, depression and anxiety: associations in the Eurolight project. J Headache Pain 2016; 17: 59. doi: 10.1186/s10194-016-0649-2Lampl C, Thomas H, Tassorelli C, et al. Headache, depression and anxiety: associations in the Eurolight project. J Headache Pain 2016; 17: 59. doi: 10.1186/s10194-016-0649-2Bendtsen L, Munksgaard SB, Tassorelli C, and the COMOESTAS Consortium. Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project). Cephalalgia 2014; 34(6): 426-433. doi: 10.1177/0333102413515338Bendtsen L, Munksgaard SB, Tassorelli C, and the COMOESTAS Consortium. Disability, anxiety and depression associated with medication-overuse headache can be considerably reduced by detoxification and prophylactic treatment. Results from a multicentre, multinational study (COMOESTAS project). Cephalalgia 2014; 34(6): 426-433. doi: 10.1177/0333102413515338Park H-K, Chu MK, Oh S-Y et al. Interim analysis of the registry for load and management of medication overuse headache (RELEASE): A multicenter, comprehensive medication overuse headache registry. Cephalalgia 2022; 42(6): 455-465. https://doi.org/10.1177/03331024211057184Park H-K, Chu MK, Oh S-Y et al. Interim analysis of the registry for load and management of medication overuse headache (RELEASE): A multicenter, comprehensive medication overuse headache registry. Cephalalgia 2022; 42(6): 455-465. https://doi.org/10.1177/03331024211057184Westergaard ML, Glűmer C, Hansen EH, et al. Medication overuse, healthy lifestyle behavior and stress in chronic headache: Results from a population-based representative survey. Cephalalgia 2016; 36(1): 15-28. doi: 10.1177/0333102415578430Westergaard ML, Glűmer C, Hansen EH, et al. Medication overuse, healthy lifestyle behavior and stress in chronic headache: Results from a population-based representative survey. Cephalalgia 2016; 36(1): 15-28. doi: 10.1177/0333102415578430Ваганова ЮС, Амелин АВ, Готовчиков АА, Тимофеева АА, Ляшок ПА, Соколов АЮ и др. Клинические особенности пациентов с лекарственно-индуцированной головной болью. Росс Журн Боли 2019; 17(3): 22-28.Ваганова ЮС, Амелин АВ, Готовчиков АА, Тимофеева АА, Ляшок ПА, Соколов АЮ и др. Клинические особенности пациентов с лекарственно-индуцированной головной болью. Росс Журн Боли 2019; 17(3): 22-28.Vaganova IS, Amelin AV, Gotovchikov AA, Timofeeva AA, Lyashok PA, Sokolov AI. Clinical characteristics of patients with medication overuse headache. Russian J of Pain 2019; 17(3): 22-28. [In Russian].Vaganova IS, Amelin AV, Gotovchikov AA, Timofeeva AA, Lyashok PA, Sokolov AI. Clinical characteristics of patients with medication overuse headache. Russian J of Pain 2019; 17(3): 22-28. [In Russian].Nielsen M, Carlsen LN, Munksgaard SB et al. Complete withdrawal is the most effective approach to reduce disability in patients with medication-overuse headache: a randomized controlled open-label trial. Cephalalgia 2019; 39(7): 863-872. https://doi.org/10.1177/0333102419828994Nielsen M, Carlsen LN, Munksgaard SB et al. Complete withdrawal is the most effective approach to reduce disability in patients with medication-overuse headache: a randomized controlled open-label trial. Cephalalgia 2019; 39(7): 863-872. https://doi.org/10.1177/0333102419828994Hagen K, Jensen R, Bøe MG et al. Medication overuse headache: A critical review of end points in recent follow-up studies. J Headache Pain 2010; 11: 373-377. doi: 10.1007/s10194-010-0221-4Hagen K, Jensen R, Bøe MG et al. Medication overuse headache: A critical review of end points in recent follow-up studies. J Headache Pain 2010; 11: 373-377. doi: 10.1007/s10194-010-0221-4Evers S, Jensen R. Treatment of medication-overuse headache — guideline of EFNS headache panel. Eur J Neurol 2011; 18(9): 1115-21. doi: 10.1111/j.1468-1331.2011.03497.x.Evers S, Jensen R. Treatment of medication-overuse headache — guideline of EFNS headache panel. Eur J Neurol 2011; 18(9): 1115-21. doi: 10.1111/j.1468-1331.2011.03497.x.Pensato U, Baraldi C, Favoni V et al. Detoxification vs nondetoxification before starting an anti-CGRP monoclonal antibody in medication overuse headache. Cephalalgia 2022; 42(7): 645-653. https://doi.org/10.1177/03331024211067791Pensato U, Baraldi C, Favoni V et al. Detoxification vs nondetoxification before starting an anti-CGRP monoclonal antibody in medication overuse headache. Cephalalgia 2022; 42(7): 645-653. https://doi.org/10.1177/03331024211067791Carlsen LN, Munksgaard SB, Jensen RH, et al. Complete detoxification is the most effective treatment of medication-overuse headache: A randomized controlled open-label trial. Cephalalgia 2018; 38(2): 225-236. doi: 10.1177/0333102417737779Carlsen LN, Munksgaard SB, Jensen RH, et al. Complete detoxification is the most effective treatment of medication-overuse headache: A randomized controlled open-label trial. Cephalalgia 2018; 38(2): 225-236. doi: 10.1177/0333102417737779Munksgaard SB, Bendtsen L, Jensen RH. Detoxification of medicationoveruse headache by a multidisciplinary treatment programme is highly effective: a comparison of two consecutive treatment methods in an open-label design. Cephalalgia 2012; 32: 834-844. https://doi.org/10.1177/0333102412451363Munksgaard SB, Bendtsen L, Jensen RH. Detoxification of medicationoveruse headache by a multidisciplinary treatment programme is highly effective: a comparison of two consecutive treatment methods in an open-label design. Cephalalgia 2012; 32: 834-844. https://doi.org/10.1177/0333102412451363Rabe K, Pageler L, Gaul C et al. Prednisone for the treatment of withdrawal headache in patients with medication overuse headache: a randomized, double-blind, placebo-controlled study. Cephalalgia 2013; 33: 202-207. https://doi.org/10.1177/0333102412462638Rabe K, Pageler L, Gaul C et al. Prednisone for the treatment of withdrawal headache in patients with medication overuse headache: a randomized, double-blind, placebo-controlled study. Cephalalgia 2013; 33: 202-207. https://doi.org/10.1177/0333102412462638Andrasik F, Grazzi L, Usai S et al. Disability in chronic migraine with medication overuse. Treatment effects through 5 years. Cephalalgia 2010; 30: 610-614. https://doi.org/10.1111/j.14682982.2009.01932.xAndrasik F, Grazzi L, Usai S et al. Disability in chronic migraine with medication overuse. Treatment effects through 5 years. Cephalalgia 2010; 30: 610-614. https://doi.org/10.1111/j.14682982.2009.01932.xСорокина НД, Перцов СС, Савин ЛА, и др. Эффекты транскраниальной магнитной и электростимуляции в терапии болевого синдрома при мигрени и головной боли напряжения. Росс Журн Боли/ 2022; 20(3): 62-68.Сорокина НД, Перцов СС, Савин ЛА, и др. Эффекты транскраниальной магнитной и электростимуляции в терапии болевого синдрома при мигрени и головной боли напряжения. Росс Журн Боли/ 2022; 20(3): 62-68.Sorokina ND, Pertsov SS, Savin LA, et al. Effects of neuromodulation of electroand magnetic neurostimulation in the treatment of pain syndrome in migraine and tension headache. Russian Journal of Pain. 2022; 20(3): 62–68. [In Russian]. https://doi.org/10.17116/pain20222003162Sorokina ND, Pertsov SS, Savin LA, et al. Effects of neuromodulation of electroand magnetic neurostimulation in the treatment of pain syndrome in migraine and tension headache. Russian Journal of Pain. 2022; 20(3): 62–68. [In Russian]. https://doi.org/10.17116/pain20222003162Noser AE, Klages KL, Gamwell KL et al. A systematic evaluation of primary headache management apps leveraging behavior change techniques. Cephalalgia 2022; 42(6): 510-523. https://doi.org/10.1177/03331024211053572Noser AE, Klages KL, Gamwell KL et al. A systematic evaluation of primary headache management apps leveraging behavior change techniques. Cephalalgia 2022; 42(6): 510-523. https://doi.org/10.1177/03331024211053572Lauritsen CG, Silberstein SD. Rationale for electrical parameter determination in external trigeminal nerve stimulation (eTNS) for migraine: A narrative review. Cephalalgia 2019; 39(6): 750-760. https://doi.org/10.1177/0333102418796781Lauritsen CG, Silberstein SD. Rationale for electrical parameter determination in external trigeminal nerve stimulation (eTNS) for migraine: A narrative review. Cephalalgia 2019; 39(6): 750-760. https://doi.org/10.1177/0333102418796781Bøe MG, Thortveit E, Vatne A, et al. Chronic headache with medication overuse: long-term prognosis after withdrawal therapy. Cephalalgia 2017; 37(13): 1215-1221. https://doi.org/10.1177/0333102416672493Bøe MG, Thortveit E, Vatne A, et al. Chronic headache with medication overuse: long-term prognosis after withdrawal therapy. Cephalalgia 2017; 37(13): 1215-1221. https://doi.org/10.1177/0333102416672493Katsarava Z, Muessig M, Dzanidze A et al. Medication overuse headache: rates and predictors for relapse in a 4-year prospective study. Cephalalgia 2005; 25: 12-15. https://doi.org/10.1111/j.14682982.2004.00789.xKatsarava Z, Muessig M, Dzanidze A et al. Medication overuse headache: rates and predictors for relapse in a 4-year prospective study. Cephalalgia 2005; 25: 12-15. https://doi.org/10.1111/j.14682982.2004.00789.xZidverk-Trajkovic JJ, Pekmezovic T, Jovanovic Z et al. Long-term predictors of remission in patients treated for medicationoveruse headache at a specialized headache center: A prospective cohort study. Cephalalgia 2018; 38(2): 265-273. https://doi.org/10.1177/0333102416683918Zidverk-Trajkovic JJ, Pekmezovic T, Jovanovic Z et al. Long-term predictors of remission in patients treated for medicationoveruse headache at a specialized headache center: A prospective cohort study. Cephalalgia 2018; 38(2): 265-273. https://doi.org/10.1177/0333102416683918Diener H-C, Dodick D, Evers S et al. Pathophysiology, prevention, and treatment of medication overuse headache. Lancet Neurol. 2019; 18(9): 891-902. doi: 10.1016/S1474-4422(19)30146-2Diener H-C, Dodick D, Evers S et al. Pathophysiology, prevention, and treatment of medication overuse headache. Lancet Neurol. 2019; 18(9): 891-902. doi: 10.1016/S1474-4422(19)30146-2

The authors declare that there are no conflicts of interest present.