avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2023-13-4-263-271DUUQGVavk-1637Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESРоль экстраклеточных нейтрофильных ловушек в развитии постковидного синдрома и его осложненийThe Role of the Innate Immune System in the Development of Postcovid Syndrome and its Complicationshttps://orcid.org/0000-0001-7825-5597ЛаринаВ. Н.LarinaV. N.

Вера Николаевна Ларина

Москва

Vera N. Larina

Moscow

larinav@mail.ruСтоделоваЕ. А.StodelovaE. A.

Москва

Moscow

https://orcid.org/0000-0001-8524-0019СалмасиЖ. М.SalmasiZh. M.

Москва

Moscow

https://orcid.org/0000-0002-3079-4089КазимирскийА. Н.KazimirskijA. N.

Москва

Moscow

https://orcid.org/0000-0003-2010-3296ПорядинГ. В.PorjadinG. V.

Москва

Moscow

ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, кафедра поликлинической терапии лечебного факультетаРоссияPirogov Russian National Research Medical University, Department of Outpatient Therapy, Faculty of General MedicineRussian FederationФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, кафедра патофизиологии и клинич еской патофизиологии лечебного факультетаРоссияPirogov Russian National Research Medical University, Department of Pathophysiology and Clinical Pathophysiology, Faculty of General MedicineRussian Federation202316082023134263271Copyright © Ларина В.Н., Стоделова Е.А., Салмаси Ж.М., Казимирский А.Н., Порядин Г.В., 20232023Ларина В.Н., Стоделова Е.А., Салмаси Ж.М., Казимирский А.Н., Порядин Г.В.Larina V.N., Stodelova E.A., Salmasi Z.M., Kazimirskij A.N., Porjadin G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/1637

На сегодняшний день в мире актуальна проблема сохранения симптомов после выздоровления от новой коронавирусной инфекции. Клиническая картинка постковидного периода имеет множественные проявления: общие, респираторные, сердечно-сосудистые, желудочно-кишечные, кожные и другие симптомы. На данный момент не определены четкие лабораторные критерии, позволяющие установить диагноз данного состояния, но показана роль нейтрофилов в развитии как острого заболевания, так и постковидного синдрома. Образование нейтрофильных экстраклеточных ловушек (нетоз) является одним из патофизиологических механизмов течения новой коронавирусной инфекции. Кроме того, доказано влияние процесса нетоза на развитие осложнений в постковидном периоде. В статье обсуждается история термина, разнообразные клинические проявления постковидного периода, а также — роль механизмов врожденного иммунитета на всех этапах течения новой коронавирусной инфекции.

To date, the problem of preserving symptoms after recovery from a new coronavirus infection is urgent in the world. This condition is called postcovid syndrome. The clinical picture of postcovid syndrome has multiple manifestations: general, respiratory, cardiovascular, gastrointestinal, skin and other symptoms. At the moment, there are no laboratory criteria for the diagnosis of this condition, but the great role of neutrophils in the development of both acute disease and postcovid syndrome has been proven. The formation of neutrophil extracellular traps (not toz) is one of the pathophysiological mechanisms of the course of a new coronavirus infection. In addition, the effect of the ketosis process on the development of complications in the postcovid period has been proven. The article discusses the history of the term, various clinical manifestations of the postcovid period, as well as the role of innate immunity mechanisms at all stages of the course of a new coronavirus infection. 

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The authors declare that there are no conflicts of interest present.