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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2023-13-6-422-435</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-1691</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>Степени тяжести постковидного синдрома: систематический обзор</article-title><trans-title-group xml:lang="en"><trans-title>Severity of Postcovid Syndrome: A Systematic Review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0423-5021</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карасева</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karaseva</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7875-1566</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Худякова</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Khudiakova</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алёна Дмитриевна Худякова</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Alena D. Khudiakova</p><p>Novosibirsk</p></bio><email xlink:type="simple">alene.elene@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5316-4664</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гарбузова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Garbuzova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4936-8362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рагино</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ragino</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1348-0253</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логвиненко</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Logvinenko</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новосибирск</p></bio><bio xml:lang="en"><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт терапии и профилактической медицины — филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук» (НИИТПМ — филиал ИЦиГ СО РАН)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences” (IIPM — Branch of IC&amp;G SB RAS)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>12</day><month>01</month><year>2024</year></pub-date><volume>13</volume><issue>6</issue><fpage>422</fpage><lpage>435</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карасева А.А., Худякова А.Д., Гарбузова Е.В., Рагино Ю.И., Логвиненко И.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Карасева А.А., Худякова А.Д., Гарбузова Е.В., Рагино Ю.И., Логвиненко И.И.</copyright-holder><copyright-holder xml:lang="en">Karaseva A.A., Khudiakova A.D., Garbuzova E.V., Ragino Y.I., Logvinenko I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/1691">https://www.medarhive.ru/jour/article/view/1691</self-uri><abstract><p>Постковидный синдром включает в себя множество состояний и симптомов, как возникших непосредственно в острый период инфекции, так и возникших после его окончания. Целью систематического обзора является определение критериев степеней тяжести постковидного синдрома. Материалы и методы. Для поиска литературных источников использовались следующие ключевые слова: «постковидный синдром», «тяжесть постковидного синдрома», «выраженность постковидного синдрома», «симптомы постковидного синдрома» на русском и английском языках. Для поиска использовались поисковые системы «eLIBRARY.RU — НАУЧНАЯ ЭЛЕКТРОННАЯ БИБЛИОТЕКА» и PubMed. gov. Были включены статьи, в которых представлено исследование пациентов, после подтвержденной лабораторно перенесенной коронавирусной инфекции с остаточными клиническими признаками и/или биохимическими изменениями, проведенное не менее чем через месяц после выздоровления от COVID-19. В анализ включались только публикации последних 3х лет (2020-2023 гг.). Результаты. Всего по двум поисковым системам было найдено 2913 публикаций, после удаления дубликатов, обзоров литературы, клинических исследований лекарственных препаратов, исследований, проведенных на животных, исследований неудовлетворяющих времени проведения после перенесённого COVID-19 и выполненных на лицах, не достигших 18-летнего возраста, для анализа было отобрано 69 статей, удовлетворяющих критериям включения в анализ. Заключение. Анализ литературы последних 3-х лет позволил определить, что наличие и степень тяжести постковидного синдрома, вероятно, может определяться наличием у пациента хотя бы одного признака из представленных в обзоре, развившегося во время или после лабораторно верифицированной инфекции COVID-19 и сохраняющегося в сроки более 4х недель от начала заболевания при условии, что он не может быть объяснен другими причинами.</p></abstract><trans-abstract xml:lang="en"><p>Postcovid syndrome includes many conditions and symptoms, both those that arose directly during the acute period of infection and the appearance of new ones. The purpose of the systematic review is to determine the criteria for the severity of postcovid syndrome. Materials and methods. The following keywords were used to search for literary sources: “postcovid syndrome”, “severity of postcovid syndrome”, “severity of postcovid syndrome” and “symptoms of postcovid syndrome” in Russian and English. We used the search engines “eLibrary.RU — Scientific Electronic Library” and PubMed.gov. Articles were included that presented a study of patients with laboratory-confirmed coronavirus infection at least a month after recovery from COVID-19 with residual clinical signs and/or biochemical changes. The analysis included only publications from the last 3 years (2020– 2023). Results. A total of 2,913 publications were found by two search engines. After removing duplicates, literature reviews, clinical studies of medicines, studies conducted on animals, studies unsatisfactory for time after acute COVID-19, and studies performed on persons under the age of 18, 69 articles were selected for analysis that meet the criteria for inclusion in the analysis. Conclusion. An analysis of the literature of the last 3 years has allowed us to determine that the presence and severity of postcovid syndrome can probably be determined by the presence in a patient of at least one of the signs presented in the review that developed during or after a laboratory-verified COVID-19 infection and persisted for more than 4 weeks from the onset of the disease and that cannot be explained by other reasons.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>постковидный синдром</kwd><kwd>степень тяжести постковидного синдрома</kwd><kwd>симптомы постковидного синдрома</kwd><kwd>систематический обзор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>postcovid syndrome</kwd><kwd>severity of postcovid syndrome</kwd><kwd>symptoms of postcovid syndrome</kwd><kwd>systematic review</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">National Institute for Health and Care Excellence (NICE). 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