avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2025-15-3-187-198GEREGMavk-2004Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLEСодержание молекул межклеточной адгезии у пациентов с COVID-19-ассоциированным поражением легкихThe Content of Intercellular Adhesion Molecules in Patients With COVID-19-Associated Lung Diseasehttps://orcid.org/0000-0003-1704-490XКараченоваА. М.KarachenovaA. M.

Караченова Анастасия Михайловна — ассистент кафедры поликлинической терапии с курсом медицинской реабилитации

Чита

Karachenova Anastasia Mikhailovna — assistant of the Department of Polyclinic Therapy with a course of medical rehabilitation

Chita 

b_a_m_2010@mail.ruhttps://orcid.org/0009-0002-1448-3069РомановаЕ. Н.RomanovaE. N.

Романова Елена Николаевна — д.м.н., доцент, заведующая кафедрой поликлинической терапии с курсом медицинской реабилитации

Чита

Romanova Elena Nikolaevna — doctor of Medical Sciences, associate Professor, Head of the Department of Polyclinic Therapy with a course of Medical Rehabilitation

Chita 

elenar-chita@yandex.ruФГБОУ ВО «Читинская государственная медицинская академия» Министерства здравоохранения Российской Федерации, кафедра поликлинической терапии с курсом медицинской реабилитацииРоссияChita State Medical Academy, Department of polyclinic therapy with a course of medical rehabilitationRussian Federation202526052025153187198Copyright © Караченова А.М., Романова Е.Н., 20252025Караченова А.М., Романова Е.Н.Karachenova A.M., Romanova E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/2004

Цель. Оценить содержание молекул межклеточной адгезии: ICAM-1, ICAM-2, ICAM-3, NCAM, VCAM-1, PECAM-1, E-sel, P-sel, EpCAM, L-sel у пациентов с COVID-19-ассоциированным поражением легких и выявить наличие взаимосвязи между их концентрацией и тяжестью течения процесса. Материалы и методы. В исследование были включены 200 пациентов после перенесенного COVID-19-ассоциированного поражения легких через 1 месяц после выписки из моностационаров г. Читы. Исследуемые были разделены на группы по 50 человек, в зависимости от степени поражения легких по результатам проведения компьютерной томографии: 1-я группа (КТ-1), 2-я группа (КТ-2), 3-я группа (КТ-3), 4-я группа (КТ-4). В группу контроля были включены 56 относительно здоровых лиц, не болевших ранее коронавирусной инфекцией и другими острыми респираторными заболеваниями за последние 3 месяца. Все исследуемые группы были сопоставимы по полу и возрасту. Содержание молекул межклеточной адгезии в сыворотки крови определяли методом иммунохимического анализа. Результаты. В результате проведенного исследования было выявлено повышенное содержание молекул межклеточной адгезии (ММА) (ICAM-1, ICAM-2, ICAM-3, NCAM, VCAM-1, PECAM-1, E-sel, P-sel, EpCAM, L-sel) у исследуемых групп больных с COVID-19-ассоциированным поражением легких в сравнении с группой контроля. Были обнаружены различия между группами пациентов с разным уровнем поражения легких по данным КТ, при исследовании некоторых молекул межклеточной адгезии. Заключение. По итогам проведенной работы выявлено, что после перенесенной коронавирусной инфекции, осложненной поражением легких, в крови наблюдается повышение концентрации молекул межклеточной адгезии — представителей всех исследуемых суперсемейств. Увеличение уровней молекул межклеточной адгезии у исследуемых пациентов отражает наличие эндотелиоза и коррелирует с тяжестью поражения легочной ткани, в том числе и в период реконвалесценции.

Objective. To evaluate the content of intercellular adhesion molecules: ICAM-1, ICAM-2, ICAM-3, NCAM, VCAM-1, PECAM-1, E-sel, P-sel, EpCAM, L-sel in patients with COVID-19-associated lung damage and to identify the relationship between their concentration and severity the flow of the process. Materials and methods. The study included 200 patients after suffering COVID-19-associated lung damage 1 month after discharge from Chita monostationals. The subjects were divided into groups of 50 people, depending on the degree of lung damage according to the results of computed tomography: Group 1 (CT-1), median age was 51.5 [50.5; 54.8]; Group 2 (CT-2), median age 57.0 [53.1; 57.0]; group 3 (CT-3), median age 52.5 [51.9; 55.0]; 4th group (CT-4), median 55.0 [53.2; 56.4]. The control group included 56 relatively healthy individuals who had not previously had coronavirus infection and other acute respiratory diseases in the last 3 months, the median age was 55.0 [51.1; 55.0]. All the study groups were comparable in gender and age. The content of intercellular adhesion molecules in blood serum was determined by immunochemical analysis. Results. The study revealed an increased content of intercellular adhesion molecules (MMA) (ICAM-1, ICAM-2, ICAM-3, NCAM, VCAM-1, PECAM-1, E-sel, P-sel, EpCAM, L-sel) in the studied groups of patients with COVID-19-associated lung damage in comparison with the control group. Differences were found between groups of patients with different levels of lung damage according to CT data, when examining some intercellular adhesion molecules. Conclusion. According to the results of the work carried out, it was revealed that after a coronavirus infection complicated by lung damage, an increase in the concentration of intercellular adhesion molecules in the blood is observed — representatives of all the studied superfamilies. An increase in the levels of intercellular adhesion molecules in the studied patients reflects the presence of endotheliosis and correlates with the severity of lung tissue damage, including during the period of convalescence.

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The authors declare that there are no conflicts of interest present.