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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2025-15-4-296-302</article-id><article-id custom-type="edn" pub-id-type="custom">NYWZYZ</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-2047</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Изменение состава ненасыщенных жирных кислот плазмы крови у мужчин, проживающих в сельских районах Новосибирской области, в зависимости от употребления алкоголя</article-title><trans-title-group xml:lang="en"><trans-title>Changes In the Composition of Unsaturated Fatty Acids in The Blood Plasma In Men Living in Rural Areas of the Novosibirsk Region, Depending on Alcohol Consumption</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0436-2549</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шрамко</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shramko</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шрамко Виктория Сергеевна — к.м.н., с.н.с. лаборатории клинических биохимических и гормональных исследований терапевтических заболеваний</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Shramko Victoria Sergeevna — candidate of medical sciences, senior researcher, laboratory of clinical biochemical and hormonal studies of therapeutic diseases</p><p>Novosibirsk</p></bio><email xlink:type="simple">nosova@211.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0484-6540</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Стахнёва</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Stakhneva</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Стахнёва Екатерина Михайловна — к.б.н, с.н.с. лаборатории клинических биохимических и гормональных исследований терапевтических заболеваний</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Stakhneva Ekaterina Mikhailovna — candidate of biological sciences, senior researcher, laboratory of clinical biochemical and hormonal studies of therapeutic diseases</p><p>Novosibirsk</p></bio><email xlink:type="simple">stahneva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2268-4186</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каштанова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashtanova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каштанова Елена Владимировна — д.б.н., вед.н.с., зав. лаборатории клинических биохимических и гормональных исследований терапевтических заболеваний</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Kashtanova Elena Vladimirovna — doctor of biological sciences, leading researcher, head of laboratory of clinical biochemical and hormonal studies of therapeutic diseases</p><p>Novosibirsk</p></bio><email xlink:type="simple">elekastanova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9270-9188</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щербаков</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shcherbakova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щербакова Лилия Валерьевна — с.н.с. лаборатории клинико-популяционных и профилактических исследований терапевтических и эндокринных заболеваний </p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Shcherbakova Lilia Valeryevna — senior researcher at the laboratory of clinical, population and preventive research of therapeutic and endocrine diseases</p><p>Novosibirsk</p></bio><email xlink:type="simple">9584792@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3538-0280</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полонская</surname><given-names>Я. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Polonskaya</surname><given-names>Ya. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полонская Яна Владимировна — д.б.н., с.н.с. лаборатории клинических биохимических и гормональных исследований терапевтических заболеваний</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Polonskaya Yana Vladimirovna — doctor of biological sciences, senior researcher, laboratory of clinical biochemical and hormonal studies of therapeutic diseases</p><p>Novosibirsk</p></bio><email xlink:type="simple">yana-polonskaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4936-8362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рагино</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ragino</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рагино Юлия Игоревна — д.м.н., профессор, член-корреспондент РАН, руководитель</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Ragino Yulia Igorevna — MD, professor, corresponding member of the russian academy of sciences, head</p><p>Novosibirsk</p></bio><email xlink:type="simple">ragino@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт терапии и профилактической медицины — филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Internal and Preventive Medicine — Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>29</day><month>07</month><year>2025</year></pub-date><volume>15</volume><issue>4</issue><fpage>296</fpage><lpage>302</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шрамко В.С., Стахнёва Е.М., Каштанова Е.В., Щербаков Л.В., Полонская Я.В., Рагино Ю.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шрамко В.С., Стахнёва Е.М., Каштанова Е.В., Щербаков Л.В., Полонская Я.В., Рагино Ю.И.</copyright-holder><copyright-holder xml:lang="en">Shramko V.S., Stakhneva E.M., Kashtanova E.V., Shcherbakova L.V., Polonskaya Y.V., Ragino Y.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/2047">https://www.medarhive.ru/jour/article/view/2047</self-uri><abstract><p>Цель исследования — изучить различия в содержании ненасыщенных жирных кислот (ННЖК) в плазме крови у мужчин, проживающих в сельских районах Новосибирской области, в зависимости от их алкогольного статуса. Материалы и методы: в рамках одномоментного эпидемиологического исследования по Новосибирской области были обследованы жители сельских районов (мужчины) в возрасте 60,04±10,55 (от 35 до 74 лет). Алкогольный статус участников определяли с помощью анкетирования. Количество разных алкогольных напитков было пересчитано в дозы чистого алкоголя. Все участники исследования были разделены на три группы по употреблению доз алкоголя в неделю: 1 группа — малое потребление алкоголя (МП); 2 группа — умеренное потребление алкоголя (УП); 3 группа — высокое потребление алкоголя (ВП). Методом высокоэффективной жидкостной хроматографии в плазме крови определяли уровни омега-3, -6 и -9 ННЖК. Результаты. Установлено, что в группе мужчин с ВП алкоголя более высокие уровни альфа-линоленовой омега-3 (p=0,041) и дигомо-гамма-линоленовой (p=0,002), докозатетраеновой (p=0,017), докозапентаеновой (p=0,023) омега-6 ННЖК в крови, по сравнению с группой мужчин с МП алкоголя. Выводы. Получены статистически значимые различия концентраций в крови альфа-линоленовой, дигомогамма-линоленовой, докозатетраеновой, докозапентаеновой ненасыщенных жирных кислот у мужчин 35-74 лет, проживающих в сельских районах Новосибирской области, в зависимости от употребления алкоголя.</p></abstract><trans-abstract xml:lang="en"><p>The aim of the study was to investigate differences in the content of unsaturated fatty acids (UFA) in blood plasma in men living of rural areas of the Novosibirsk region, depending on their alcohol status. Materials and methods: as part of a single-stage epidemiological study in the Novosibirsk region, rural residents (men) aged 60.04±10.55 (from 35 to 74 years) were examined. The alcohol status of the participants was determined by means of a questionnaire. The number of different alcoholic beverages was recalculated in doses of pure alcohol. All study participants were divided into three groups based on alcohol consumption per week: group 1 — low alcohol consumption (LC); group 2 — moderate alcohol consumption (MC); group 3 — high alcohol consumption (HC). The levels of omega-3, -6, and -9 UFA in blood plasma were determined by high-performance liquid chromatography. Results: It was found that the group of men with HC had higher concentrations of omega-3 alpha-linolenic acid (p=0,041) and omega-6 digomo-gamma-linolenic (p=0,002), docosatetraenoic (p=0,017), docosapentaenoic (p=0,023) UFA in blood, compared with group of men with LC. Conclusions: In the study, we found statistically significant differences in blood concentrations of alpha-linolenic acid, digomo-gammalinolenic acid, docosathetraenoic acid, and docosapentaenoic acid unsaturated fatty acids were obtained in men aged 35-74 years living in rural areas of the Novosibirsk region, depending on alcohol consumption.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>жирные кислоты</kwd><kwd>кровь</kwd><kwd>алкоголь</kwd><kwd>факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>fatty acids</kwd><kwd>blood</kwd><kwd>alcohol</kwd><kwd>risk factors</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа проведена в рамках бюджетной темы по Государственному заданию № FWNR-2024-0004</funding-statement><funding-statement xml:lang="en">The work was carried out within the framework of the budget topic under State Assignment No. FWNR-2024-0004</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. 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