avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2025-15-5-346-357NAVYDBavk-2079Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLEХарактеристики психоневрологического фенотипа постковидного синдромаCharacteristics of The Neuropsychiatric Phenotype of Postcovid Syndromehttps://orcid.org/0000-0002-7846-7933ЗоринаВ. В.ZorinaV. V.

Зорина Валентина Валентиновна — младший научный сотрудник сектора изучения моногенных форм распространенных заболеваний человека

Новосибирск

Valentina V. Zorina — Junior Researcher, Sector for the Study of Monogenic Forms of Common Human Diseases

Novosibirsk

walentina.zorina@bk.ruhttps://orcid.org/0000-0002-0423-5021КарасеваА. А.KarasevaA. A.

Карасева Александра Александровна — на учный сотрудник лаборатории генетических и средовых детерминант жизненного цикла человека

Новосибирск

Alexandra A. Karaseva — Researcher, Laboratory of Genetic and Environmental Determinants of the Human Life Cycle

Novosibirsk

sas96@bk.ruhttps://orcid.org/0000-0001-5316-4664ГарбузоваЕ. В.GarbuzovaE. V.

Гарбузова Евгения Витальевна — к.м.н., научный сотрудник лаборатории генетических и средовых детерминант жизненного цикла человека

Новосибирск

Evgeniya V. Garbuzova — PhD, Researcher, Laboratory of Genetic and Environmental Determinants of the Human Life Cycle

Novosibirsk

stryukova.j@mail.ruhttps://orcid.org/0000-0001-7875-1566АфанасьеваА. Д.AfanasyevaA. D.

Афанасьева Алёна Дмитриевна — к.м.н., заведу ющая лабораторией генетических и средовых детерминант жизненного цикла человека 

Новосибирск

Alena D. Afanasyeva — MD, PhD, Head of the Laboratory of Genetic and Environmental Determinants of the Human Life Cycle

Novosibirsk

alena.dmytryevna@yandex.ruhttps://orcid.org/0000-0001-9644-7904ДумаС. В.DumaS. V.

Дума Светлана Николаевна — к.м.н., старший научный сотрудник лаборатории психологических и социологических проблем внутренних болезней; заведующая консультативно-диагностическим отделением клиники

Новосибирск

Svetlana N. Duma — MD, PhD, Senior Researcher, Laboratory of Psychological and Sociological Problems of Internal Diseases; Head of the Consultative and Diagnostic Department

Novosibirsk

duma.svetlana@yandex.ruhttps://orcid.org/0000-0003-1407-269XСухановА. В.SukhanovA. V

Суханов Андрей Владимирович — д.м.н., старший научный сотрудник лаборатории психологических и социологических проблем терапевтических заболеваний

Новосибирск

Andrey V. Sukhanov — MD, PhD, Senior Researcher, Laboratory of Psychological and Sociological Problems of Therapeutic Diseases

Novosibirsk

25081973@mail.ruhttps://orcid.org/0000-0001-6108-1025ШахтшнейдерЕ. В.ShakhtschneiderE. V.

Шахтшнейдер Елена Владимировна — к.м.н., ведущий научный сотрудник лаборатории молекулярно-генетических исследований терапевтических заболеваний; заведующая сектором изучения моногенных форм распространенных заболеваний человека 

Новосибирск

Elena V. Shakhtshneider — MD, PhD, Leading Researcher, Laboratory of Molecular Genetic Studies of Therapeutic Diseases; Head of the Sector for the Study of Monogenic Forms of Common Human Diseases

Novosibirsk

2117409@mail.ruhttps://orcid.org/0000-0003-1348-0253ЛогвиненкоИ. И.LogvinenkoI. I.

Логвиненко Ирина Ивановна — д.м.н., профессор, ведущий научный сотрудник лаборатории профилактической медицины, заместитель руководителя по лечебной работе

Новосибирск

Irina I. Logvinenko — MD, Professor, Leading Researcher, Laboratory of Preventive Medicine, Deputy Head for Medical Work

Novosibirsk

111157@mail.ruhttps://orcid.org/0000-0002-4936-8362РагиноЮ. И.RaginoYu. I.

Рагино Юлия Игоревна — д.м.н, профессор, член-корреспондент РАН, руководитель

Новосибирск

Yulia I. Ragino — Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences

Novosibirsk

ragino@mail.ruФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»РоссияFederal State Budgetary Scientific Institution «Federal Research Center Institute of Cytology and Genetics of the Siberian branches of the Russian Academy of S ciences»Russian FederationНаучно-исследовательский институт терапии и профилактической медицины — филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»РоссияScientific Research Institute of Therapy and Preventive Medicine is a branch of the Federal State Budgetary Scientific Institution «Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»Russian FederationФедеральное государственное бюджетное научное учреждение «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»; Научно-исследовательский институт терапии и профилактической медицины — филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»РоссияFederal State Budgetary Scientific Institution «Federal Research Center Institute of Cytology and Genetics of the Siberian branches of the Russian Academy of S ciences»; Scientific Research Institute of Therapy and Preventive Medicine is a branch of the Federal State Budgetary Scientific Institution «Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»Russian Federation202525092025155346357Copyright © Зорина В.В., Карасева А.А., Гарбузова Е.В., Афанасьева А.Д., Дума С.В., Суханов А.В., Шахтшнейдер Е.В., Логвиненко И.И., Рагино Ю.И., 20252025Зорина В.В., Карасева А.А., Гарбузова Е.В., Афанасьева А.Д., Дума С.В., Суханов А.В., Шахтшнейдер Е.В., Логвиненко И.И., Рагино Ю.И.Zorina V.V., Karaseva A.A., Garbuzova E.V., Afanasyeva A.D., Duma S.V., Sukhanov A.V., Shakhtschneider E.V., Logvinenko I.I., Ragino Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/2079

Цель. Изучить характеристики психоневрологического фенотипа постковидного синдрома у реконвалесцентов COVID-19. Материалы и методы. Выборка 270 реконвалесцентов COVID-19 (средний возраст — 53,2±13,2; 130 (48,1 %) мужчин): 62 (23,0 %) без постковидного синдрома и 208 (77,0 %) с постковидным синдромом. В подгруппе с постковидным синдромом 134 (64,4 %) реконвалесцента имели психоневрологический фенотип. В ходе исследования учитывались данные анамнеза, проводилась оценка психоневрологического статуса по шкалам: Hospital Anxiety and Depression Scale (HADS), Multidimensional Fatigue Inventory (MFI-20), Symptom Checklist-90-Revised (SCL-90), 36-Item Short-Form Health Survey (SF-36), все пациенты были консультированы врачом неврологом, сомнологом и терапевтом. Результаты. Структура психоневрологического фенотипа: инсомния (n=74, 55,2 %), выраженная астения (шкала MFI-20, n=55, 41,0 %), тревога и депрессия (шкала HADS, n=37, 27,6 %, n=32, 23,9 %, соответственно), аносмия/дизосмия (n=13, 9,7 %), агевзия/дисгевзия (n=6, 4,5 %). По данным опросника SF-36 в группе лиц с психоневрологическим фенотипом было выявлено выраженное снижение показателей по всем субшкалам. По данным опросника SCL-90-R в группе с психоневрологическим фенотипом наблюдалось выраженное повышение показателей по всем субшкалам. У женщин с психоневрологическим фенотипом отмечались следующие особенности: показатели были ниже по шкалам: физическое функционирование в 1,1 раза (р=0,017), ролевое функционирование, обусловленное физическим состоянием в 1,6 раза (р=0,031) (шкала SF-36), выше показатели обсессивно-компульсивного расстройства в 1,7 раза (р=0,028), депрессии в 1,5 раза (р=0,005), тревожности в 2 раза (р=0,017) (шкала SCL-90), по результатам оценки шкалы HADS частота депрессии у женщин с психоневрологическим фенотипом постковидного синдрома выше в 3 раза (р=0,043) по сравнению с мужчинами, имеющим этот же фенотип. Заключение. Психоневрологический фенотип постковидного синдрома характеризуется наличием у пациентов инсомнии, выраженной астении, тревожных, депрессивных расстройств, аносмии/дизосмии и агевзии/дисгевзии. Лица с психоневрологическим фенотипом имеют сниженные показатели качества жизни и уровня психологического благополучия личности по всем субшкалам, согласно опросникам SF-36 и SCL-90-R. Частота встречаемости психоневрологического фенотипа, а также выраженность психопатологической симптоматики статистически выше в группе женщин.

Aim. To study the characteristics of the neuropsychiatric phenotype of postCOVID syndrome in COVID-19 convalescents. Materials and methods. A sample of 270 COVID-19 convalescents (mean age — 53.2±13.2, (n=130, 48.1 % men)): 62 (23.0 %) without postCOVID syndrome and 208 (77.0 %) with postCOVID syndrome. In the subgroup with postCOVID syndrome, 134 (64.4 %) convalescents had a neuropsychiatric phenotype. The study took into account medical history data, assessed the neuropsychiatric status on the following scales: Hospital Anxiety and Depression Scale (HADS), Multidimensional Fatigue Inventory (MFI-20), Symptom Checklist-90-Revised (SCL-90), 36-Item Short-Form Health Survey (SF-36), all patients were consulted by a neurologist, a somnologist and a therapist. Results. The structure of the neuropsychiatric phenotype: insomnia (n=74, 55.2 %), severe asthenia (MFI-20 scale, n=55, 41.0 %), anxiety and depression (HADS scale, n=37, 27.6 %, n=32, 23.9 %, respectively), anosmia/dysosmia (n=13.9.7 %), ageusia/dysgeusia (n=6, 4.5 %). According to the SF-36 questionnaire, in the group of people with a neuropsychiatric phenotype, a marked decrease in indicators was detected in all subscales. According to the SCL-90-R questionnaire, the group with the neuropsychiatric phenotype showed a marked increase in all subscales. The following features were noted in women with a neuropsychiatric phenotype: indicators were lower on the scales: physical functioning by 1.1 times (p=0.017), role-playing functioning due to physical condition by 1.6 times (p=0.031) (SF-36 scale), indicators of obsessive-compulsive disorder by 1.7 times higher (p=0.028), depression 1.5 times (p=0.005), anxiety 2 times (p=0.017) (SCL-90 scale), according to the results of the HADS scale assessment, the incidence of depression in women with the neuropsychiatric phenotype of postCOVID syndrome is 3 times higher (p=0.043) compared with men, having the same phenotype. Conclusion. The neuropsychiatric phenotype of postCOVID syndrome is characterized by the presence of insomnia, severe asthenia, anxiety, depressive disorders, anosmia/dysosmia, and ageusia/dysgeusia. Individuals with a neuropsychiatric phenotype have reduced indicators of quality of life and the level of psychological well-being of the individual in all subscales, according to the SF-36 and SCL-90-R questionnaires. The incidence of neuropsychiatric phenotype, as well as the severity of psychopathological symptoms, is higher in the group of women.

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The authors declare that there are no conflicts of interest present.