avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2015-0-3-33-39avk-401Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLEНОВЫЕ ВОЗМОЖНОСТИ ДИАГНОСТИКИ ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТИ У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПАНОВЫЕ ВОЗМОЖНОСТИ ДИАГНОСТИКИ ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТИ У ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПАСнетковаА. А.СнетковаА. А.

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anichkaz@mail.ruТимофееваН. Ю.ТимофееваН. Ю.АдашеваТ. В.АдашеваТ. В.ГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова», кафедра поликлинической терапии РФ, г. МоскваРоссияГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова», кафедра поликлинической терапии РФ, г. МоскваRussian Federation201528062015033339Copyright © Снеткова А.А., Тимофеева Н.Ю., Адашева Т.В., 20152015Снеткова А.А., Тимофеева Н.Ю., Адашева Т.В.Снеткова А.А., Тимофеева Н.Ю., Адашева Т.В.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/401

Целью исследования явилось изучение плазменных концентраций галектина-3 и мозгового натрийуретического пептида (BNP), показателей антиоксидантной защиты, оксидативного стресса, системного воспаления и эндотелиальной дисфункции, параметров центральной гемодинамики.

Материалы и методы

Материалы и методы: В исследование включены пациенты с хронической сердечной недостаточностью (ХСН) без метаболических нарушений (n=31) и с сочетанием ХСН и сахарного диабета (СД) 2 типа (n=60).

Результаты

Результаты: Пациенты с ХСН, имеющие в качестве сопутствующего заболевания СД 2 типа имеют более высокие уровни биомаркеров ХСН (галектина-3 (Р≤0,001), BNP (Р≤0,001), а также более значимые изменения в параметрах гемодинамики. В группе пациентов ХСН с сохраненной фракцией выброса (ФВ) выявлены более высокие уровни галектина-3 (0,955 [0,886; 1,010] нг/мл) по сравнению с пациентами с низкой ФВ ЛЖ (0,816 [0,776; 0,934] нг/мл) (Р=0,01). Уровень галектина-3 выше 1нг/мл ассоциирован с неблагоприятным прогнозом по частоте госпитализаций у пациентов с ХСН.

The aim of the study was to examine the plasma concentrations of galectin-3 and brain natriuretic peptide (BNP), indicators of antioxidant protection, oxidative stress, systemic inflammation and endothelial dysfunction, central hemodynamic parameters.

Materials and Methods

Materials and Methods: The study included patients with CHF without metabolic disturbances (n = 30) and with the combination of heart failure and diabetes mellitus (DM) type 2 (n = 60). 

Results

Results: Patients with chronic heart failure, having as co-morbidity of DM have higher levels of biomarkers of heart failure (galectin-3 (R≤0,001), BNP (R≤0,001), as well as more significant changes in hemodynamic parameters. In the group of patients with CHF with preserved ejection fraction (EF) revealed higher levels of galectin-3 (0.955 [0.886; 1,010] ng / ml) compared to patients with reduced ejection fraction (0.816 [0.776; 0.934] ng / ml) (P = 0,01). The level of galectin-3 above 1ng / ml is associated with a poor prognosis for the frequency of hospitalizations in patients with CHF.

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The authors declare that there are no conflicts of interest present.