avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2014-0-6-34-37avk-417Research ArticleВОПРОСЫ КОМОРБИДНОСТИПОЛИМОРФИЗМ ГЕНА ЭНДОТЕЛИАЛЬНОЙ СИНТАЗЫ ОКСИДА АЗОТА И САХАРНЫЙ ДИАБЕТ 2 ТИПА (литературный обзор)ПОЛИМОРФИЗМ ГЕНА ЭНДОТЕЛИАЛЬНОЙ СИНТАЗЫ ОКСИДА АЗОТА И САХАРНЫЙ ДИАБЕТ 2 ТИПА (литературный обзор)СорокинаЮ. А.СорокинаЮ. А.lzwx@inbox.ruЛовцоваЛ. В.ЛовцоваЛ. В.ГБОУ ВПО «Нижегородская государственная медицинская академия», кафедра общей и клинической фармакологии, г. Нижний НовгородRussian Federation201428122014063437Copyright © Сорокина Ю.А., Ловцова Л.В., 20142014Сорокина Ю.А., Ловцова Л.В.Сорокина Ю.А., Ловцова Л.В.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/417

Данный обзор литературы посвящён проблеме интерпретации научных изысканий в области полиморфизма различных генов, в частности гена эндотелиальной синтазы азота. Трудность заключается в правильной оценке ассоциаций аллелей и различных состояний, которые имеют клиническое значение. Особенно важно точное определение ассоциаций полиморфизма генов при СД, поскольку данное заболевание чаще всего приводит к микрои макроангиопатиям. Информация о подобных ассоциациях и связях предоставляет возможности для поиска новых тактик и мишеней для воздействия, что развивает персонифицированные подход к терапии пациентов с СД. 

This review is devoted to a problem of interpretations of scientific data in the field of genes polymorphism researches, especially endothelial nitric oxide synthase. It is difficult to evaluate gene associations with variety of clinically significant conditions. To define associations is essential in patients with diabetes mellitus because of its cardiovascular complications. The data about associations gives us abilities to develop new targets and tactics, providing personal approach to a disease management. 

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The authors declare that there are no conflicts of interest present.