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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2015-0-5-12</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-450</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>ИЗУЧЕНИЕ ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ТОНКОЙ КИШКИ ПРИ ЖЕЛЧНОКАМЕННОЙ БОЛЕЗНИ</article-title><trans-title-group xml:lang="en"><trans-title>STUDYING OF FUNCTIONAL CONDITION OF THE SMALL INTESTINE IN CHOLELITHIASIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вахрушев</surname><given-names>Я. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Vakhrushev</surname><given-names>Ya. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра пропедевтики внутренних болезней с курсом сестринского дела,</p><p>г. Ижевск</p></bio><bio xml:lang="en"><p>Department of Propaedeutics of Internal Diseases,</p><p>Izhevsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукашевич</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukashevich</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра пропедевтики внутренних болезней с курсом сестринского дела,</p><p>г. Ижевск</p></bio><bio xml:lang="en"><p>Department of Propaedeutics of Internal Diseases,</p><p>Izhevsk</p></bio><email xlink:type="simple">anna.lukashevich.89@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунов</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра пропедевтики внутренних болезней с курсом сестринского дела,</p><p>г. Ижевск</p></bio><bio xml:lang="en"><p>Department of Propaedeutics of Internal Diseases,</p><p>Izhevsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Ижевская государственная медицинская академия»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Izhevsk State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2015</year></pub-date><volume>0</volume><issue>5</issue><fpage>22</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вахрушев Я.М., Лукашевич А.П., Горбунов А.Ю., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Вахрушев Я.М., Лукашевич А.П., Горбунов А.Ю.</copyright-holder><copyright-holder xml:lang="en">Vakhrushev Y.M., Lukashevich A.P., Gorbunov A.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/450">https://www.medarhive.ru/jour/article/view/450</self-uri><abstract><p>Целью работы является комплексное исследование функционального состояния тонкой кишки на разных стадиях желчнокаменной болезни (ЖКБ).</p><sec><title>Материалы и методы</title><p>Материалы и методы. Обследовано 47 пациентов с ЖКБ, из них 29 больных с I (докаменной) стадией и 18 — со II (каменной) стадией. В оценке функционального состояния тонкой кишки использованы клинические данные и результаты нагрузочных проб сахарами. Полостное пищеварение изучалось с помощью нагрузочной пробы полисахаридом (растворимым крахмалом), пристеночное пищеварение — по степени усвоения дисахарида (сахарозы), всасывание — с использованием моносахарида (глюкозы). Уровень глюкозы в крови определяли натощак, затем после перорального приема 50 г глюкозы, сахарозы или крахмала через 30, 60 и 120 минут.</p></sec><sec><title>Результаты</title><p>Результаты. У большинства больных ЖКБ выявляются клинико-функциональные расстройства тонкой кишки. При оценке полостного пищеварения прирост гликемии был достоверно снижен у больных ЖКБ при I стадии на 43% и при II стадии — на 66% в сравнении с контролем. При оценке пристеночного пищеварения у больных II стадией ЖКБ прирост гликемии был снижен по сравнению с группой контроля и с I стадией ЖКБ на 30% и 19% соответственно.</p></sec><sec><title>Заключение</title><p>Заключение. При ЖКБ при I стадии наблюдается преимущественно снижение полостного пищеварения, а при II стадии нарушаются все этапы гидролизно-резорбционного процесса в тонкой кишке.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. Complex research of the functional condition of the small intestine in different stages of cholelithiasis.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. 47 patients with different stages of cholelithiasis were examined. There were 29 patients with the first (prestone) stage and 18 — with the second (stone) stage of cholelithiasis. In an assessment of the functional condition of the small intestine were used clinical data and results of the load tests by sugars. Cavitary digestion was studied by load test with polysaccharide (soluble starch), membrane digestion — with disaccharide (sucrose), absorption — with monosaccharide (glucose). Glucose level in blood was determined on an empty stomach, then after oral reception of 50g of glucose, sucrose or starch in 30, 60 and 120 minutes.</p></sec><sec><title>Results</title><p>Results. Researchers showed that in the most of patients with cholelithiasis there were disturbances in clinical and functional condition of the small intestine. In an assessment of the cavitary digestion the level of glycemia was authentically lowered by 43% in prestone stage and by 66% in stone stage of cholelithiasis in comparison with control. In an assessment of membrane digestion in patients with the stone stage of cholelithiasis the level of glycemia was lowered in comparison with group of control and with the prestone stage by 30% and 19% respectively.</p></sec><sec><title>Conclusion</title><p>Conclusion. In prestone stage of cholelithiasis there were decrease of the cavitary digestion primary, and in stone stage of cholelithiasis — all stages of hydrolysis-resorptive process in the small intestine were disturbed.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>желчнокаменная болезнь</kwd><kwd>тонкая кишка</kwd><kwd>малабсорбция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cholelithiasis</kwd><kwd>small intestine</kwd><kwd>malabsorption</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Вахрушев Я.М., Горбунов А.Ю., Сучкова Е.В. Желчнокаменная болезнь как возможное проявление системной патологии органов пищеварения: монография. Ижевск, 2015; 148.</mixed-citation><mixed-citation xml:lang="en">Vakhrushev Ya.M., Gorbunov A.Yu., Suchkova E.V. Cholelithiasis is as possible manifestation of the system pathology of digestive organs: monograph. Izhevsk. 2015; 148. 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