avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2016-6-1-13-19avk-484Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESСОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ ОБ ИНФЕКЦИИ, ВЫЗВАННОЙ ВИРУСОМ ГЕРПЕСА ЧЕЛОВЕКА 6 ТИПАCURRENT CONCEPT OF HUMAN HERPESVIRUS TYPE 6 INFECTIONМелёхинаЕ. В.MelehinaE. V.e.melekhina@mail.ruМузыкаА. Д.MuzykaA. D.КалугинаМ. Ю.KaluginaM. Ju.ГореловА. В.GorelovA. V.ЧугуноваО. Л.ChugunovaO. L.Клинический отдел инфекционной патологии ЦНИИ Эпидемиологии Роспотребнадзора, Москва, РоссияРоссияClinical department of infectious diseases, Federal Budget Institution of Science «Central Research Institute of Epidemiology», Moscow, Russian FederationRussian FederationКлинический отдел инфекционной патологии ЦНИИ Эпидемиологии Роспотребнадзора, Москва, Россия Кафедра госпитальной педиатрии No 1 педиатрического факультета ГБОУ ВПО Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, Москва, РоссияРоссияClinical department of infectious diseases, Federal Budget Institution of Science «Central Research Institute of Epidemiology», Moscow, Russian Federation Department of hospital Pediatrics No 1 pediatric faculty, N.I.Pirogov Russian National Research Medical University, Moscow, Russian FederationRussian FederationКафедра госпитальной педиатрии No 1 педиатрического факультета ГБОУ ВПО Российский национальный исследовательский медицинский университет имени Н.И. Пирогова, Москва, РоссияРоссияDepartment of hospital Pediatrics No 1 pediatric faculty, N.I.Pirogov Russian National Research Medical University, Moscow, Russian FederationRussian Federation201604032016611319Copyright © Мелёхина Е.В., Музыка А.Д., Калугина М.Ю., Горелов А.В., Чугунова О.Л., 20162016Мелёхина Е.В., Музыка А.Д., Калугина М.Ю., Горелов А.В., Чугунова О.Л.Melehina E.V., Muzyka A.D., Kalugina M.J., Gorelov A.V., Chugunova O.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/484

Инфекция, вызванная вирусом герпеса человека 6 типа, относящегося к β-герпесвирусам, широко распространена и активно изучается в последние годы в связи с несовершенством диагностики, а также участием в формировании хронической соматической патологии. Согласно международной классификации, принятой в 2012 г., вирус герпеса человека 6А типа и вирус герпеса человека 6В типа являются самостоятельными таксономическими единицами, которые различаются по последовательности нуклеотидов, строению, эпидемиологии, возрасту инфицирования, особенностям течения, чувствительности к терапии. В обзоре приведены современные данные о клинических проявлениях, способах диагностики и терапии инфекции вируса герпеса человека 6 типа в разном возрасте.

Human herpes virus type 6 infection is widely distributed. It is extensively studied recent years due to the imperfection of diagnostics, as well as participa- tion in the formation of chronic somatic pathology. According to the international classification 2012, the human herpes virus 6A and human herpesvirus 6B are separate taxonomic units, which vary in sequence of nucleotides, structure, epidemiology, age of infection, the characteristics of flow, sensitivity to therapy. The review contains current data on clinical manifestations, methods of diagnosis and therapy of human herpes virus 6 infectionat different ages. 

вирус герпеса человека 6 типаизоляты типа А и В вируса герпеса человека 6 типапротивовирусная терапияhuman herpes virus type 6isolates A and Вof human herpesvirus type 6antiviral therapyReferencesВашура Л.В., Савенкова М.С. Герпес 6-го типа (эпидемиология, диагностика, клиника). Лечащий врач; 2014; 11: 18-25.Vashura L.V., Savenkova M.S. Herpes 6 type (epidemiology, diagnostics, clinical presentation). Lechashhij vrach. 2014; 11: 18-25. (In Russian).Исаков В.А., Архипова Е.И., Исаков Д.В. Герпесвирусные инфекции человека: руководство для врачей/под ред. В.А. Исакова. Спб.: Спецлит. 2013; 670 c.Isakov V.A., Arhipova E.I., Isakov D.V. Human herpesvirus infections: a guide for physicians. Speclit. 2013; 670 p. (In Russian).Калугина М.Ю. Эпидемиологические характеристики инфекции, вызванной вирусом герпеса 6-го типа: дисс. канд. биол. наук. М, 2009.Kalugina M.Ju. Epidemiological characteristics of infections caused by herpes virus 6: diss. kand. biol. nauk. M. 2009; 169 p. (In Russian).Мелёхина Е.В., Чугунова О.Л., Музыка А.Д. и др. Роль герпесвирусных инфекций в формировании патологии у детей. Особенности течения, диагностика и лечение инфекции, ассоциированной с вирусом герпеса человека 6 типа у детей. Методические рекомендации. М. 2014; 50 c.Melehina E.V., Chugunova O.L., Muzyka A.D. et al. Role of herpesvirus infections in the formation of pathology in children. Сharacteristic of course, diagnosis and treatment infections associated with the human herpes virus 6 in children. Metodicheskie rekomendacii. M. 2014; 50 p. (In Russian).Никольский М.А. Клинические варианты первичной инфекции, вызванной вирусами герпеса человека 6-го и 7-го типов, у детей раннего возраста. Педиатрия. 2008; 87(4): 52-55.Nikol'skij M.A. Clinical variants of primary infection caused by the human herpes viruses 6 and 7, in children of early age. Pediatrija. 2008; 87(4): 52-55. (In Russian).Никольский М.А., Голубцова В.С. Хромосомноинтегрированный вирус герпеса человека 6 типа. Инфекция и иммунитет. 2015; 5(1): 7–14.Nikol'skij M.A., Golubcova V.S. Chromosomal-integrated human herpes virus 6. Infekcija i immunitet. 2015; 5(1): 7–14. (In Russian).Новосад Е.В. Инфекционный мононуклеоз, ассоциированный с вирусом герпеса 6 типа: автореф. дис. канд. мед. наук. М. 2010; 127с.Novosad E.V. Infectious mononucleosis, associated with herpes virus type 6: dis. kand. med. nauk. M. 2010; 127 p. (In Russian).Романцов М.Г., Ершов Ф.И. Часто болеющие дети. Современная фармакотерапия. М.: ГЭОТАР-Медиа. 2006; 190 с.Romancov M.G., Ershov F.I. Chasto bolejushhie deti. Sovremennaja farmakoterapija. M.: GJeOTAR-Media. 2006; 190. (In Russian).Agut H., Bonnafous P., Gautheret-Dejean A. Laboratory and clinical aspects of human herpesvirus 6 infections. Clin.Microbiol.Rev. 2015; 28(2): 313-335.Agut H., Bonnafous P., Gautheret-Dejean A. Laboratory and clinical aspects of human herpesvirus 6 infections. Clin.Microbiol.Rev. 2015; 28(2): 313-335.Arbuckle J.H., Medveczky P.G. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes.Infect. 2011; 13(8-9): 731–741.Arbuckle J.H., Medveczky P.G. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes.Infect. 2011; 13(8-9): 731–741.Bounaadja L., Piret J., Goyette N. et al. Analysis of HHV-6 mutations in solid organ transplant recipients at the onset of cytomegalovirus disease and following treatment with intravenous ganciclovir or oral valganciclovir. J. Clin. Virol. 2013; 58(1): 279-82.Bounaadja L., Piret J., Goyette N. et al. Analysis of HHV-6 mutations in solid organ transplant recipients at the onset of cytomegalovirus disease and following treatment with intravenous ganciclovir or oral valganciclovir. J. Clin. Virol. 2013; 58(1): 279-82.Caserta M.T., Hall C.B., Canfield R.L. et al. Early developmental outcomes of children with congenital HHV-6 infection. Pediatrics. 2014; 134(6): 1111-1118.Caserta M.T., Hall C.B., Canfield R.L. et al. Early developmental outcomes of children with congenital HHV-6 infection. Pediatrics. 2014; 134(6): 1111-1118.Crosslin D.R.,Carrell D.S., Amber A. Burt. et al. Genetic variation in the HLA region is associated with susceptibility to herpes zoster. Genes and Immunity. 2015; 16: 1–7.Crosslin D.R.,Carrell D. S., Amber A. Burt. et al. Genetic variation in the HLA region is associated with susceptibility to herpes zoster. Genes and Immunity. 2015; 16: 1–7.Hall C.B., Caserta M.T., Schnabel K.C. et al. Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. J Infect Dis. 2010; 201(4): 505-507.Hall C.B., Caserta M.T., Schnabel K.C. et al. Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. J Infect Dis. 2010; 201(4): 505-507.Hall C.B., Caserta M.T., Schnabel K.C. et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr. 2004; 145(4): 472-477.Hall C.B., Caserta M.T., Schnabel K.C. et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). J Pediatr. 2004; 145(4): 472-7.Kainth M.K., Fisher S.G., Fernandez D. et al. Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: a cross-sectional study. F1000Res. 2013; 2: 269.Kainth M.K., Fisher S.G., Fernandez D. et al. Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: a cross-sectional study. F1000Res. 2013; 2: 269.KauferB.B.,FlamandL.ChromosomallyintegratedHHV-6:impacton virus, cell and organismal biology. Curr. Opin. Virol. 2014; 9: 111–118.Kaufer B.B., Flamand L. Chromosomally integrated HHV-6: impact on virus, cell and organismal biology. Curr. Opin. Virol. 2014; 9: 111–118.Kazlauskas D., Venclovas Č. Herpesviral helicase-primase subunit UL8 is inactivated B-family polymerase. Bioinformatics. 2014; 30(15): 2093–2097.Kazlauskas D., Venclovas Č. Herpesviral helicase-primase subunit UL8 is inactivated B-family polymerase. Bioinformatics. 2014; 30(15): 2093–2097.Ketsueki R. Salt-wasting nephropathy induced by foscarnet treatment for HHV-6 encephalitis in a hematopoietic stem cell transplant. 2008; 49(1): 40-45.Ketsueki R. Salt-wasting nephropathy induced by foscarnet treatment for HHV-6 encephalitis in a hematopoietic stem cell transplant. 2008; 49(1): 40-45.Lanari M., Papa I., Venturi V. et al. Congenital infection with human herpesvirus 6 variant B associated with neonatal seizures and poor neurological outcome. J Med Virol. 2003; 70(4): 628-632.Lanari M., Papa I., Venturi V. et al. Congenital infection with human herpesvirus 6 variant B associated with neonatal seizures and poor neurological outcome. J Med Virol. 2003; 70(4): 628-632.LimH. K., Seppänen M., Hautala T. et al. TLR3 deficiency in herpes simplex encephalitis: High allelic heterogeneity and recurrence risk. Neurology. 2014; 83 (21): 1888-1897.LimH. K., Seppänen M., Hautala T. et al. TLR3 deficiency in herpes simplex encephalitis: High allelic heterogeneity and recurrence risk. Neurology. 2014; 83 (21): 1888-1897.Muylaert I., Zhao Z., Per Elias. UL52 Primase Interactions in the Herpes Simplex Virus 1 Helicase-Primase Are Affected by Antiviral Compounds and Mutations Causing Drug Resistance. The Journal Of Biological Chemistry. 2014; 289(47): 32583–32592.Muylaert I., Zhao Z., Per Elias. UL52 Primase Interactions in the Herpes Simplex Virus 1 Helicase-Primase Are Affected by Antiviral Compounds and Mutations Causing Drug Resistance. The Journal Of Biological Chemistry. 2014; 289(47): 32583–32592.Piret J., Boivin G. Antiviral drug resistance in herpesviruses other than cytomegalovirus. Rev. Med. Virol. 2014; 24: 186–218.Piret J., Boivin G. Antiviral drug resistance in herpesviruses other than cytomegalovirus. Rev. Med. Virol. 2014; 24: 186–218.Pohlmann C., Johannes Schetelig, Ulrike Reuner et al. Cidofovir and Foscarnet for Treatmentof Human Herpesvirus 6 Encephalitisin a Neutropenic Stem Cell Transplant Recipient/ CID 2007; 44: e118-e120.Pohlmann C., Johannes Schetelig, Ulrike Reuner et al. Cidofovir and Foscarnet for Treatmentof Human Herpesvirus 6 Encephalitisin a Neutropenic Stem Cell Transplant Recipient/ CID 2007; 44: e118-e120.Rdos P., Dde Ferreira, Nóbrega F. et al. Current status of herpesvirus identification in the oral cavity of HIV-infected children. Rev. Soc. Bras. Med. Trop. 2013; 46(1): 15-19.Rdos P., Dde Ferreira, Nóbrega F. et al. Current status of herpesvirus identification in the oral cavity of HIV-infected children. Rev. Soc. Bras. Med. Trop. 2013; 46(1): 15-19.Shiohara T., Iijima M., Ikezawa Z. et al. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br. J. Dermatol. 2007; 156: 1083–1084.Shiohara T., Iijima M., Ikezawa Z. et al. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br. J. Dermatol. 2007; 156: 1083–1084.Subhajit Biswas, Hugh J Field, Madingley Road. Pointer Herpes simplex virus helicase–primase inhibitors: recent findings from the study of drug resistance mutations. Antiviral Chemistry & Chemotherapy. 2008; 19: 1–6Subhajit Biswas, Hugh J Field, Madingley Road. Pointer Herpes simplex virus helicase–primase inhibitors: recent findings from the study of drug resistance mutations. Antiviral Chemistry & Chemotherapy. 2008; 19: 1–6Veeder B., Hempelmann Т. A febrile exanthem occurring in childhood (exanthem subitum). JAMA 1921; 77: 1787-1789.Veeder B., Hempelmann Т. A febrile exanthem occurring in childhood (exanthem subitum). JAMA 1921; 77: 1787-1789.Yamanishi K., Okuno Т., Shiraki К. et al. Identification of human herpesvirus 6 as a casual agent for exanthema subitum. Lancet. 1988; 1: 1065.Yamanishi K., Okuno Т., Shiraki К. et al. Identification of human herpesvirus 6 as a casual agent for exanthema subitum. Lancet. 1988; 1: 1065.Yoshimichi H., Atsuo I. Minimal Dose Interferon Suppository Treatment Suppresses Viral Replication with Platelet Counts and Serum Albumin Levels Increased in Chronically Hepatitis C VirusInfected Patients: A Phase 1b, Placebo-Controlled, Randomized Study. Journal of interferon & cytokine research. 2014;34(2): 111-116.Yoshimichi H., Atsuo I. Minimal Dose Interferon Suppository Treatment Suppresses Viral Replication with Platelet Counts and Serum Albumin Levels Increased in Chronically Hepatitis C Virus-Infected Patients: A Phase 1b, Placebo-Controlled, Randomized Study. Journal of interferon & cytokine research. 2014; 34(2): 111-116.Zahorsky J. Roseola infantum. JAMA. 1913; 61: 446-450.Zahorsky J. Roseola infantum. JAMA. 1913; 61: 446-450.

The authors declare that there are no conflicts of interest present.