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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2012-0-1-30-34</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-49</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>ГАСТРОЭЗОФАГЕАЛЬНАЯ РЕФЛЮКСНАЯ БОЛЕЗНЬ: ОСОБЕННОСТИ БАЗИСНОЙ ТЕРАПИ</article-title><trans-title-group xml:lang="en"><trans-title>ГАСТРОЭЗОФАГЕАЛЬНАЯ РЕФЛЮКСНАЯ БОЛЕЗНЬ: ОСОБЕННОСТИ БАЗИСНОЙ ТЕРАПИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аванян</surname><given-names>Н. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Аванян</surname><given-names>Н. Л.</given-names></name></name-alternatives><bio xml:lang="ru"><p>консультативный отдел, г. Ростов-на-Дону</p></bio><bio xml:lang="en"><p>консультативный отдел, г. Ростов-на-Дону</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Яковлев</surname><given-names>А. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра гастроэнтерологии и эндоскопии с курсом клинической фармакологии ФПК и ППС</p></bio><bio xml:lang="en"><p>кафедра гастроэнтерологии и эндоскопии с курсом клинической фармакологии ФПК и ППС</p></bio><email xlink:type="simple">gastroklinika@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мезжуева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Мезжуева</surname><given-names>Е. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>поликлиническое отделение</p></bio><bio xml:lang="en"><p>поликлиническое отделение</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халявкин</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Халявкин</surname><given-names>С. Н.</given-names></name></name-alternatives><bio xml:lang="ru"><p>амбулаторно-поликлиническое отделение № 1, г. Ростов-на-Дону</p></bio><bio xml:lang="en"><p>амбулаторно-поликлиническое отделение № 1, г. Ростов-на-Дону</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паленый</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Паленый</surname><given-names>А. И.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра ультразвуковой диагностики ФПК и ППС</p></bio><bio xml:lang="en"><p>кафедра ультразвуковой диагностики ФПК и ППС</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУ РО Областной консультативно-диагностический центр</institution><country>Россия</country></aff><aff xml:lang="en"><institution>ГБУ РО Областной консультативно-диагностический центр</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО Ростовский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>ГБОУ ВПО Ростовский государственный медицинский университет</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>НУЗ Дорожная клиническая больница на станции Ростов-Главный ОАО «РЖД»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>НУЗ Дорожная клиническая больница на станции Ростов-Главный ОАО «РЖД»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>МБУЗ Клинико-диагностический центр «Здоровье»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>МБУЗ Клинико-диагностический центр «Здоровье»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2012</year></pub-date><volume>0</volume><issue>1</issue><fpage>30</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Аванян Н.Л., Яковлев А.А., Мезжуева Е.В., Халявкин С.Н., Паленый А.И., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Аванян Н.Л., Яковлев А.А., Мезжуева Е.В., Халявкин С.Н., Паленый А.И.</copyright-holder><copyright-holder xml:lang="en">Аванян Н.Л., Яковлев А.А., Мезжуева Е.В., Халявкин С.Н., Паленый А.И.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/49">https://www.medarhive.ru/jour/article/view/49</self-uri><abstract><p>Авторы приводят собственный клинический опыт лечения больных пожилого возраста с гастроэзофагеальной рефлюксной болезнью (ГЭРБ) с использованием разных схем терапии: монотерапии ингибитором протонной помпы (Омепразол Сандоз) и использованием комбинации Н2-гистаминоблокатора с прокинетиком в разных режимах наблюдения. Показано, что назначение препарата Омепразол Сандоз предпочтительнее с точки зрения эффективности, безопасности и стоимости лечения.</p></abstract><trans-abstract xml:lang="en"><p>The authors present their own clinical experience in treating elderly patients with gastroesophageal reflux disease using different therapy regimens: monotherapy with proton pump inhibitors (Omeprazole Sandoz) and H2-histamine blockers using a combination of a prokinetic in different modes of observation. It is shown that use of Omeprazole Sandoz is preferable in terms of efficacy, safety and cost of treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гастроэзофагеальная рефлюксная болезнь</kwd><kwd>пептический эзофагит</kwd><kwd>ингибиторы протонной помпы</kwd><kwd>Омепразол Сандоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gastroesophageal reflux disease</kwd><kwd>peptic esophagitis</kwd><kwd>proton pump inhibitors</kwd><kwd>Omeprazole Sandoz</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">ЗАО «Сандоз»</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Иваников О.И., Исаков В.А., Маев И.В. Рациональная диагностика и терапия гастроэзофагеальной рефлюксной болезни // Тер. архив. 2004. № 2. С. 71–75.</mixed-citation><mixed-citation xml:lang="en">Иваников О.И., Исаков В.А., Маев И.В. Рациональная диагностика и терапия гастроэзофагеальной рефлюксной болезни // Тер. архив. 2004. № 2. С. 71–75.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Трухманов А.С. Гастроэзофагеальная рефлюксная болезнь: клиника заболевания, лечение // Болезни органов пищеварения. 2001. Т. 3, № 1. С. 19–24.</mixed-citation><mixed-citation xml:lang="en">Трухманов А.С. Гастроэзофагеальная рефлюксная болезнь: клиника заболевания, лечение // Болезни органов пищеварения. 2001. Т. 3, № 1. С. 19–24.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Collen M.J., Abdullian J.D, Chen Y.C. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy // Amer. J. Gastroenterol. 1995. Vol. 90. P. 1053–1057.</mixed-citation><mixed-citation xml:lang="en">Collen M.J., Abdullian J.D, Chen Y.C. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy // Amer. J. Gastroenterol. 1995. Vol. 90. P. 1053–1057.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Donnellan C., Sharma N., Preston C., Moayyedi P. Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease // Cochrane Database Syst. Rev. 2005. CD003245.</mixed-citation><mixed-citation xml:lang="en">Donnellan C., Sharma N., Preston C., Moayyedi P. Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease // Cochrane Database Syst. Rev. 2005. CD003245.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Moayyedi P., Talley N.J. Gastro-oesophageal reflux disease // Lancet. 2006. Vol. 367, № 9528. P. 2086–100.</mixed-citation><mixed-citation xml:lang="en">Moayyedi P., Talley N.J. Gastro-oesophageal reflux disease // Lancet. 2006. Vol. 367, № 9528. P. 2086–100.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mold J.W., Reed L.E., Davis A.B. еt al. Prevalence of gastroesophageal reflux in elderly patients in a primary care setting // Amer. J. Gastroenterol. 1991. Vol. 86, № 8. P. 965–970.</mixed-citation><mixed-citation xml:lang="en">Mold J.W., Reed L.E., Davis A.B. еt al. Prevalence of gastroesophageal reflux in elderly patients in a primary care setting // Amer. J. Gastroenterol. 1991. Vol. 86, № 8. P. 965–970.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nealis T.B., Howden C.W. Is there a dark side to long-term proton pump inhibitor therapy? // Am. J. Ther. 2008. Vol. 15, № 6. P. 536–42.</mixed-citation><mixed-citation xml:lang="en">Nealis T.B., Howden C.W. Is there a dark side to long-term proton pump inhibitor therapy? // Am. J. Ther. 2008. Vol. 15, № 6. P. 536–42.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rai A., Orlando R. Gastroesophageal reflux disease // Curr. Opin. Gastroenterol. 1998. Vol. 14. P. 326–333.</mixed-citation><mixed-citation xml:lang="en">Rai A., Orlando R. Gastroesophageal reflux disease // Curr. Opin. Gastroenterol. 1998. Vol. 14. P. 326–333.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Richter J.E. Gastroesophageal reflux disease in the older patient: presentation, treatment, and complications // Amer. J. Gastroenterol. 2000. Vol. 95, № 2. P. A.</mixed-citation><mixed-citation xml:lang="en">Richter J.E. Gastroesophageal reflux disease in the older patient: presentation, treatment, and complications // Amer. J. Gastroenterol. 2000. Vol. 95, № 2. P. A.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma N., Donnellan C., Preston C. et al. A systematic review of symptomatic outcomes used in oesophagitis drug therapy trials // Gut. 2004. № 53 (suppl. 4). P. 58–65.</mixed-citation><mixed-citation xml:lang="en">Sharma N., Donnellan C., Preston C. et al. A systematic review of symptomatic outcomes used in oesophagitis drug therapy trials // Gut. 2004. № 53 (suppl. 4). P. 58–65.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Tutuian R., Katz P.O., Ahmed F., Korn S., Castell D.O. Over-the-counter H2-receptor antagonists do not compromise intragastric pH control with proton pump inhibitors // Aliment. Pharmacol. Ther. 2002. Vol. 16, № 3. Р. 473–7.</mixed-citation><mixed-citation xml:lang="en">Tutuian R., Katz P.O., Ahmed F., Korn S., Castell D.O. Over-the-counter H2-receptor antagonists do not compromise intragastric pH control with proton pump inhibitors // Aliment. Pharmacol. Ther. 2002. Vol. 16, № 3. Р. 473–7.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Van Pinxteren B., Numans M.E., Bonis P.A., Lau J. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastroesophageal reflux disease-like symptoms and endoscopy negative reflux disease // Cochrane Database Syst. Rev. 2006. CD002095.</mixed-citation><mixed-citation xml:lang="en">Van Pinxteren B., Numans M.E., Bonis P.A., Lau J. Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastroesophageal reflux disease-like symptoms and endoscopy negative reflux disease // Cochrane Database Syst. Rev. 2006. CD002095.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zacny J., Zamakhshary M., Sketris I., Veldhuyzen van Zanten S. Systematic review: the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton pump inhibitors for gastro-oesophageal reflux disease patients // Aliment. Pharmacol. Ther. 2005. Vol. 21, № 11. Р. 1299–312.</mixed-citation><mixed-citation xml:lang="en">Zacny J., Zamakhshary M., Sketris I., Veldhuyzen van Zanten S. Systematic review: the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton pump inhibitors for gastro-oesophageal reflux disease patients // Aliment. Pharmacol. Ther. 2005. Vol. 21, № 11. Р. 1299–312.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
