avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2016-6-4-58-64avk-555Research ArticleРАЗБОР КЛИНИЧЕСКИХ СЛУЧАЕВANALYSIS OF CLINICAL CASESПОРАЖЕНИЕ ЛЕГКИХ И ПЕЧЕНИ ПРИ ЛЕЧЕНИИ ПАРАЦЕТАМОЛОМPULMONARY AND LIVER DAMAGE DURING TREATMENT WITH ACETAMINOPHEN (PARACETAMOL)ДворецкийЛ. И.DvoretskiL. I.

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dvoretski@mail.ruКовалевскаяА. Н.KovalevskajaA. N.КолендоС. Е.KolendoS. E.СергееваЕ. В.SergeevaE. V.Первый МГМУ им. И.М.Сеченова, Москва, Россия ГКБ им. С.С. Юдина ДЗМ, Москва, РоссияРоссияThe First Moscow State Medical University n. I.M. Sechenov, Moscow, Russia City Clinical Hospital n. S.S. Yudin, DHM, Moscow, RussiaRussian Federation201631082016645864Copyright © Дворецкий Л.И., Ковалевская А.Н., Колендо С.Е., Сергеева Е.В., 20162016Дворецкий Л.И., Ковалевская А.Н., Колендо С.Е., Сергеева Е.В.Dvoretski L.I., Kovalevskaja A.N., Kolendo S.E., Sergeeva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/555

Описание больного, у которого на фоне приема ацетаминофена (парацетамола) развилось поражение легких в виде интерстициального пневмонита с выраженной дыхательной недостаточностью. Кроме того, у пациента наблюдалось значительное повышение активности АЛТ и АСТ без клинических признаков поражения печени. На фоне назначения глюкокортикоидов отмечено обратное развитие рентгенологических изменений в легких наряду с нормализацией показателей печеночных ферментов. Подчеркивается редкость интерстициального пневмонита вследствие приема ацетаминофена (парацетамола), особенно в сочетании с поражением печени. Представленная история болезни пациента является первым описанием случая лекарственного легочно-печеночного синдрома при приеме парацетамола.

This is a case report of pulmonary damage in the form of intestinal pneumonitis with severe respiratory failure during administration of acetaminophen (paracetamol). In addition, significant increase of ALT and AST levels without clinical signs of liver damage was observed in this patient. After glucocorticoids administration regression of radiological abnormal findings in the lungs along with normalization of liver enzymes values were registered. The rarity of interstitial pneumonitis induced by acetaminophen (paracetamol), especially in combination with liver damage, is emphasized. The presented patient history is the first case report of drug-induced hepatopulmonary syndrome during acetaminophen (paracetamol) administration.

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The authors declare that there are no conflicts of interest present.