References

avk

Архивъ внутренней медицины

The Russian Archives of Internal Medicine

2226-67042411-6564

“SINAPS” LLC

10.20514/2226-6704-2017-7-2-95-106

avk-638

Research Article

ОБЗОРНЫЕ СТАТЬИ

REVIEW ARTICLES

IGG4-СОПРЯЖЕННАЯ ПАТОЛОГИЯ: СОСТОЯНИЕ ПРОБЛЕМЫ

IGG4-RELATED DISEASE: CONDITION OF THE PROBLEM

Василенко

В. В.

Vasilenko

V. V.

Виноградов

Д. Л.

Vinogradov

D. L.

wind007@mail.ru

Бурлакова

А. С.

Burlakova

A. S.

Первый Московский государственный медицинский университет имени И. М. СеченоваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation

2017

26042017

7295106

2017

Василенко В.В., Виноградов Д.Л., Бурлакова А.С.

Vasilenko V.V., Vinogradov D.L., Burlakova A.S.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.medarhive.ru/jour/article/view/638

Физиологическая роль IgG4 еще не до конца изучена. Известно, что они, как и другие антитела, участвуют в инактивации и удалении из организма веществ, идентифицированных иммунной системой, как чужеродные антигены. Также IgG4 реализуют эффекторные механизмы: связывание со специализированными иммунными клетками, осуществляющими после такого взаимодействия фагоцитоз чужеродных агентов или уничтожение зараженных клеток организма за счет зависимой от антител цитотоксичности. Мнения относительно способности IgG4 активировать комплемент зачастую противоречивы. Повышение концентрации иммуноглобулинов данного подкласса может свидетельствовать не только о развитии инфекционных и аллергических состояний, но и о наличии у пациента IgG4-сопряженной патологии. IgG4-сопряженная патология (IgG4-СП) — относительно недавно выделенная группа патологических состояний, и ее изучение становится все более актуальным. Это связано с тем, что она включает в себя состояния, которые ранее считались самостоятельными нозологическими единицами. В последние годы IgG4-СП диагностируется все чаще, так как получает все большее признание у медицинской общественности. Данный обзор включает новейшую информацию из последних зарубежных публикаций.

The physiological role of IgG4 is poorly understood yet. It is known, that they, like other antibodies, are involved in the inactivation and removal of organism agent, which are identified as foreign antigens by immune system. IgG4 also release effector mechanisms: contact with the specialized immune cells, which perform phagocytosis foreign antigens or destruction of the infected cells by antibody-dependet cytotoxicity, after this interaction. Opinions about the ability to activate complement system are divided. The elevation concentration of that subclass immunoglobulins can be an indicator not only of development of infectious and allergic conditions, but also the presence of the IgG4-related disease in a patient´s organism. IgG4-rd is a recently selected group of pathological conditions and it is becoming relevant to study. It is because they include the conditions, which have been thought to be separate nosology previously. In recent years IgG4 –RD has been diagnosed more often, because it has been increasingly being recognized in the medical community. This review includes the latest information from the latest foreign publication.

IgG4-сопряженная патологияIgG4-СПлимфоплазмоцитарная инфильтрацияфиброз

IgG4-related diseaseIgG4-RDlymphoplasmacytic infiltrationfibrosis

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The authors declare that there are no conflicts of interest present.