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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">avk</journal-id><journal-title-group><journal-title xml:lang="ru">Архивъ внутренней медицины</journal-title><trans-title-group xml:lang="en"><trans-title>The Russian Archives of Internal Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2226-6704</issn><issn pub-type="epub">2411-6564</issn><publisher><publisher-name>“SINAPS” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20514/2226-6704-2017-7-2-145-151</article-id><article-id custom-type="elpub" pub-id-type="custom">avk-644</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РАЗБОР КЛИНИЧЕСКИХ СЛУЧАЕВ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANALYSIS OF CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>ЛИМФОМА БЕРКИТТА С ПРЕИМУЩЕСТВЕННЫМ ПОРАЖЕНИЕМ ЖЕЛУДКА (КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ)</article-title><trans-title-group xml:lang="en"><trans-title>BURKITT’S LYMPHOMA WITH A PRIMARY LESION OF THE STOMACH (CLINICAL OBSERVATION)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Касымова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kasimova</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Therapy department.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Удалов</surname><given-names>Ю. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Udalov</surname><given-names>Yu. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Therapy department.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кореньков</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korenkov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва, e-mail: vyacheslav-korenkov@yandex.ru</p></bio><bio xml:lang="en"><p>Therapy department.</p></bio><email xlink:type="simple">vyacheslav-korenkov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильченко</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilchenko</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва</p></bio><bio xml:lang="en"><p>Therapy department.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ГНЦ ФМБЦ имени А.И. Бурназяна ФМБА России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SSC A. I. Burnazyan Federal Biophysical Centre оf FMBA of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2017</year></pub-date><volume>7</volume><issue>2</issue><fpage>145</fpage><lpage>151</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Касымова О.А., Удалов Ю.Д., Кореньков В.В., Ильченко Л.Ю., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Касымова О.А., Удалов Ю.Д., Кореньков В.В., Ильченко Л.Ю.</copyright-holder><copyright-holder xml:lang="en">Kasimova A.O., Udalov Y.D., Korenkov V.V., Ilchenko L.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.medarhive.ru/jour/article/view/644">https://www.medarhive.ru/jour/article/view/644</self-uri><abstract><p>В статье описан случай первичной лимфомы Беркитта желудка у 29-летнего  мужчины. Приведены данные литературы об этиологии, диагностике и морфологических характеристиках первичных лимфом желудка, затронуты вопросы тактики лечения, варианты схем цитостатической терапии.</p><p>В описанном клиническом примере дана история болезни  пациента: с 16 лет установлен диагноз  хронический гастродуоденит,  пациент периодически принимал омепразол с положительным эффектом, данных об инфицированности Нр и эрадикации нет. В апреле 2016 г. отметил ухудшение самочувствия в виде появления дискомфорта в эпигастральной области. В апреле 2016 г. на амбулаторном этапе выполнена ЭГДС, где выявлена опухоль антрального отдела желудка, взята биопсия образования.  При гистологическом исследовании атипичных клеток не выявлено, в связи с чем в мае 2016 г. был госпитализирован в ФМБЦ им А.И. Бурназяна для дообследования.</p><p>В статье приведены данные лабораторно-инструментального обследования,  результаты ЭГДС, КТ органов грудной и брюшной полостей, приведены результаты цитологического, иммуногистохимического, цитогенетического исследований.</p><p>Пациенту были проведены три курса цитостатической терапии. Первый курс цитостатической терапии начат в июне 2016 г., пациент перенес его удовлетворительно, в постцитостатическом периоде отмечалась лейкопения 2,5 тыс/мкл, на фоне чего развилось вирусное поражение слизистой языка, проводилась терапия виролексом с положительной динамикой.</p><p>По ЭГДС-контролю отмечалась  выраженная положительная  динамика. Второй и третий курс проведены в июле-августе 2016 г., лечение перенес удовлетворительно. В сентябре 2016 г. выписан под динамическое наблюдение гематологом.</p><p>Статья обращает внимание практикующих врачей на то, что при отсутствии специфических клинических проявлений, основой диагностики лимфомы в данном клиническом примере является своевременное проведение эндоскопического исследования с гистологическим, иммуногистохимическим и цитогенетическим исследованием биоптата.</p></abstract><trans-abstract xml:lang="en"><p>The article describes the case of the primary stomach lymphoma of the stomach in a 29-year-old man. The literature data on the etiology, diagnosis and morphological characteristics of the primary lymphomas of the stomach are presented, the questions of treatment tactics, variants of cytostatic therapy schemes are touched upon.</p><p>In the described clinical example, the patient’s medical history is given: from the age of 16 the chronic gastroduodenitis is diagnosed, the patient periodically took omeprazole with a positive effect, there is no evidence of infection with Hp and there is no eradication. In April 2016, he noted the deterioration of health in the form of the appearance of discomfort in the epigastric region. In April 2016, an EHDS was performed at the outpatient stage, where an antral tumor of the stomach was detected, and a biopsy of the formation was taken. Histological examination of atypical cells was not revealed, and in connection with this, in May 2016, he was hospitalized at the A.M. Burnazyan for additional examination.</p><p>The article presents  data  of laboratory  and instrumental examination,  the  results  of EGDS, CT of thoracic  and abdominal  cavities, cytological, immunohistochemical,  and cytogenetic studies.</p><p>The patient  was given three courses of cytostatic  therapy. The first course of cytostatic  therapy was started  in June 2016, the patient  transferred it satisfactorily, in the post-cytostatic period there was a leukopenia of 2,5 thousand  cells/μl, against which the viral lesion of the tongue mucosa developed, and the therapy with virolex was performed with positive dynamics.</p><p>The EGD control showed marked positive dynamics. The second and third courses were conducted in July-August 2016, treatment was satisfactory. In September 2016 he was discharged for dynamic observation by a hematologist.</p><p>The article draws the attention of medical practitioners  to the fact that, in the absence of specific clinical manifestations, the basis for the diagnosis of lymphoma in this clinical example is the timely conduct of an endoscopic study with histological, immunohistochemical and cytogenetic  study of the biopsy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лимфома Беркитта</kwd><kwd>поражение желудка</kwd><kwd>диагностика</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Burkitt’s lymphoma of lesions of the stomach</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Барях Е.А., Кравченко С.К., Обухова Т.Н., и соавт. Лимфома Беркитта: клиника, диагностика, лечение. Клин. Онкогематол. 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