avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2017-7-3-181-187avk-652Research ArticleОБЗОРНЫЕ СТАТЬИREVIEW ARTICLESРОЛЬ ВИТАМИНОВ-АНТИОКСИДАНТОВ В ЛЕЧЕНИИ РЕВМАТОИДНОГО АРТРИТАTHE ROLE OF VITAMINS IN THE TREATMENT OF RHEUMATOID ARTHRITISМаксимоваЖ. В.MaximovaZh. V.jannamd@yandex.ruМаксимовД. М.MaximovD. M.jannamd@yandex.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации, ЕкатеринбургРоссияUral State Medical University, EkaterinburgRussian Federation20172805201773181187Copyright © Максимова Ж.В., Максимов Д.М., 20172017Максимова Ж.В., Максимов Д.М.Maximova Z.V., Maximov D.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/652

Известно, что воспалительный процесс при ревматоидном артрите (РА) поддерживается при участии свободных радикалов. Витамины- антиоксиданты способны нейтрализовать последствия оксидативного повреждения, поэтому существуют предположения, что они могут облегчать симптомы и предотвращать прогрессирование РА. В настоящей статье представлен обзор современных исследований, в которых изучалось клиническое значение добавочного употребления витаминов-антиоксидантов у пациентов с РА. В целом, по результатам немногочисленных клинических испытаний, небольшая симптоматическая эффективность была выявлена только при использовании высоких доз препаратов витамина Е. При этом получены достоверные данные о пользе богатой антиоксидантами средиземноморской диеты, на фоне которой у больных РА отмечалось снижение воспалительной активности, повышение функциональных возможностей и улучшение общего самочувствия. Таким образом, пациентам РА скорее следует рекомендовать увеличение употребления богатых антиоксидантами продуктов (зерновые, фрукты, овощи), нежели дополнительный прием витаминных препаратов.

 

It is well known that the inflammatory process in rheumatoid arthritis (RA) is mediated by free radicals. Antioxidant vitamins can neutralize oxidative cell damage, so they suggested alleviate symptoms and prevent progression of RA. This article provides an overview of a current literature about clinical role of the antioxidant vitamins in patients with RA. In general, only a few clinical trials focused on this issue, and just a high dose vitamin E supplementation demonstrated moderate clinical efficacy in RA. On the other hand, convincing evidence exist that Mediterranean diet, rich in antioxidants, may reduce inflammatory activity, increase physical functioning and improve general well-being. In conclusion, patients with RA should follow antioxidant-rich diet (grains, fruits, vegetables) rather than take vitamin supplementation.

 

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The authors declare that there are no conflicts of interest present.