avkАрхивъ внутренней медициныThe Russian Archives of Internal Medicine2226-67042411-6564“SINAPS” LLC10.20514/2226-6704-2018-8-2-137-144avk-771Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLEКЛИНИЧЕСКИЕ ПРОЯВЛЕНИЯ ПОЛИНЕЙРОПАТИИ У ОНКОЛОГИЧЕСКИХ БОЛЬНЫХ НА ФОНЕ ХИМИОТЕРАПИИ И ВОЗМОЖНОСТЬ ИХ ФАРМАКОКОРРЕКЦИИ (РЕЗУЛЬТАТЫ НАБЛЮДАТЕЛЬНОЙ ПРОГРАММЫ ПОСЕЙДОН)CLINICAL SIGNS OF CHEMOTHERAPY-INDUCED NEUROPATHY IN CANCER PATIENTS AND PHARMACOTHERAPY CORRECTION OPTIONSЗолотовскаяИ. А.ZolotovskayaiaI. A.zolotovskay@list.ruДавыдкинИ. Л.DavydkinI. L.ЛокштановаТ. М.LokshtanovaT. M.ОрловА. Е.OrlovA. E.ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РоссииРоссияSamara State Medical UniversityRussian FederationГосударственное бюджетное учреждение здравоохранения «Самарский областной клинический онкологический диспансер»РоссияSamara Regional Oncological ClinicRussian Federation20182903201882137144Copyright © Золотовская И.А., Давыдкин И.Л., Локштанова Т.М., Орлов А.Е., 20182018Золотовская И.А., Давыдкин И.Л., Локштанова Т.М., Орлов А.Е.Zolotovskayaia I.A., Davydkin I.L., Lokshtanova T.M., Orlov A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.medarhive.ru/jour/article/view/771

Цель нашего исследования — изучить клинические проявления полинейропатии у онкологических больных на фоне химиотерапии и возможность их фармакокоррекции препаратами витаминов группы В. Материал и методы. На первом этапе в период с мая по сентябрь 2017 года после периода скрининга методом последовательного включения в исследования вошло 219 пациентов (средний возраст 50,4±6,9 лет) из которых 105 (46,7%) женщин, проходящих курсы химиотерапии в Самарском областном онкологическом диспансере. Методом стандартного неврологического осмотра и опроса пациентов устанавливались клинические признаки полинейропатии: ее локализация, основные проявления, включая чувствительные и/или болевые расстройства. На II этапе проведена рандомизация лиц, имеющих клинические проявления нейропатии (n=60), на две группы: в 1-й (n=30) группе больные получали препараты группы витаминов В, во 2-й группе (n=30) — не получали витамины группы В. Длительность наблюдения составила 60 дней. Результаты. Установлено, что распространённость полинейропатии среди больных онкологического профиля, получающих химиотерапию, составляет 77,2%. Фенотип клинических проявлений, степень их выраженности, локализация, вероятно, обусловлены используемым химиотерапевтическим препаратом. Показана эффективность использования ступенчатой терапии препаратами группы В в аспекте уменьшения клинических проявлений полинейропатии. 

The study objective was to analyze the clinical signs of chemotherapy-induced neuropathy (CIPN) in cancer patients and explore pharmacotherapy correction options using vitamin B. Materials and design. During Part 1 lasting from May to September 2017, we screened and then enrolled 219 consecutive patients (mean age of 50.4 ± 6.9 years); 105 (46.7%) of them were women undergoing chemotherapy treatment cycles at Samara Regional Oncological Clinic. Through standard-of-care neurological examination and patient responses we defined the clinical signs of polyneuropathy: its localization, primary symptoms, including sensory impairments and/or pain, and then randomized the patients into two groups: group 1 received vitamin B agents, and group 2 received no vitamin B. The patients were observed for 60 days. Results. The incidence of polyneuropathy in oncology patients receiving chemotherapy turns out to be very high. The phenotype of clinical signs and their severity and localization is probably related to the type of the drug agent used. We have proved the efficacy of the step-down therapy with vitamin B agents used to improve clinical signs of polyneuropathy. 

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The authors declare that there are no conflicts of interest present.