The Possibilities of Using the Reds System in Clinical Practice

   A review of the literature is presented, which describes a unique mobile non-invasive system for measuring the total volume of fluid in the lungs ReDS, a study of its effectiveness on animals and volunteers, as well as experience of use in clinical practice. An analysis of domestic and foreign literary sources of the portals PubMed, Web of Science, Nature, published in the period from 2012–2024, was carried out. Every year around the world there is a tendency to increase the number of patients with chronic heart failure. The key problem of the diagnostic search remains the early detection of decompensation of chronic heart failure. One of the reliable and early markers of impending acute decompensation of chronic heart failure is monitoring of the fluid volume in the lungs. Determining the fluid volume indicator can serve as a criterion for adjusting the therapy, which, in turn, should affect the frequency of re-hospitalizations. Thus, vital for the further management of patients with acute decompensation of chronic heart failure is the control of volume, as well as the identification and quantification of the degree of congestion. Fluid volume assessment is a key factor in the management of patients with chronic heart failure in inpatient and outpatient settings. ReDS monitoring significantly reduces the likelihood of readmission to hospital with chronic heart failure within 3 months compared with patients not tested on the ReDS system.

1. Fomin, I. V., Polyakov D. S., Vajsberg A. R. 25 years of real clinical practice in the treatment of chronic heart failure in the Russian Federation — are we doing everything right in 2022. Original research. 2022; 4:27–37 [In Russian].

2. Arutyunov, A. G., Arutyunov G. P. Repeated hospitalizations in patients with acute CHF decompensation syndrome. Features, prognostic significance, new approaches to reducing the risk of their occurrence. RMJ. 2013; 21(12): 612–616 [In Russian].

3. Ziaeian B., Fonarow G. C. The prevention of hospital readmissions in heart failure. The Journal Progress in cardiovascular diseases. 2016; 58(4): 379–385. DOI: 10.1016/j.pcad.2015.09.004.

4. Zhirov I. V., Nasonova S. N., Tereshchenko S. N. Acute decompensation of heart failure: state of the problem. Terapevticheskii arkhiv. 2022. 94(9):1047–1051. doi: 10.26442/00403660.2022.09.201839 [In Russian].

5. Mueller C, McDonald K, de Boer RA, et al. Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations. Eur J Heart Fail. 2019; 21(6):715–31. doi: 10.1002/ejhf.1494.

6. Serpik V. G., Kulikov A. Yu., Protsenko M. V., et al. Health technology assessment and clinical role of remote dielectric sensing in the diagnosis and control of the treatment of chronic heart failure in the Russian Federation. Pharmacoeconomics: theory and practice. 2023; 11(3):24–35 doi: 10.30809/phe.3.2023.3 [In Russian].

7. Yang Y., Fathy A. E. See-through-wall imaging using ultra wide-band short-pulse radar system. IEEE. 2005; 3B: 334–337. doi: 10.1109/APS.2005.1552508.

8. Zhirov I. V., Nasonova S. N., Syrkhaeva A. A., et al. Optimization of intravascular volume determination in patients with acute decompensated heart failure. Russian Journal of Cardiology. 2022; 27(5): 5039. doi: 10.15829/1560–4071–2022–5039 [In Russian].

9. Amir O, Rappaport D, Zafrir B, et al. A novel approach to monitoring pulmonary congestion in heart failure: initial animal and clinical experiences using remote dielectric sensing technology. Congest Heart Fail. 2013; 19(3): 149–155. doi: 10.1111/chf.12021.

10. Curran L., Peck K., Bensimhon D. A. Descriptive Analysis of ReDS Technology across the Continuum of Care. Journal of Cardiac Failure. 2019; 25(8S): S135–S136. doi: 10.1016/j.cardfail.2019.07.390.

11. Offer Amir, Zaher S. Azzam, Tamar Gaspar, et al. Validation of remote dielectric sensing (ReDSTM) technology for quantification of lung fluid status: Comparison to high resolution chest computed tomography in patients with and without acute heart failure. International Journal of Cardiology. 2016; 221: 841–846. doi: 10.1016/j.ijcard.2016.06.323.

12. Imamura T., Gonoi W., Hori M. Validation of Noninvasive Remote Dielectric Sensing System to Quantify Lung Fluid Levels. Journal of Clinical Medicine. 2022; 11(1): 164. doi: 10.3390/jcm11010164.

13. Uriel N., Sayer G., Imamura T., et al. Relationship Between Noninvasive Assessment of Lung Fluid Volume and Invasively Measured Cardiac Hemodynamics. Journal of the American Heart Association. 2018; 7(22): e009175. doi: 10.1161/JAHA.118.009175.

14. Sattar Y., Zghouzi M., Suleiman A. M., et al. Efficacy of remote dielectric sensing (ReDS) in the prevention of heart failure rehospitalizations: a meta-analysis. Journal Of Community Hospital Internal Medicine Perspectives. 2021; 11(5): 646–652. doi: 10.1080/20009666.2021.955451.

15. Barghash M.H., Lala A., Giustino G., et al. Use of Remote Dielectric Sensing (ReDS) as Point-of-Care Testing Following Heart Failure Hospitalization and Risk of 30-Day Readmission. The Journal of Heart and Lung Transplantation. 2019; 38(4): S140–S141. doi: 10.1016/j.healun.2019.01.335.

16. Izumida T., Imanura T., Koi T., et al. Prognostic impact of residual pulmonary congestion assessed by remote dielectric sensing system in patients admitted for heart failure. ESC Heart Fail. 2024 Jun; 11(3): 1443-1451. doi: 10.1002/ehf2.14690. Epub 2024 Feb 14.

17. Rappaport D. Noninvasive monitoring of pulmonary congestion using a remote dielectric sensing (ReDS) system: a prospective single-arm study in patients suffering from heart failure. J Card Fail. 2012. 18(8S): S61. doi: 10.1016/j.cardfail.2012.06.207.

18. Syrkhaeva A. A., Nasonova S. N., Zhirov I. V., et al. Possibilities of instrumental determination of volemic status in patients with acute decompensation of chronic heart failure. Terapevticheskii arkhiv. 2023; 95(9): 769–775. doi: 10.26442/00403660.2023.09.202375.

19. Bensimhon D., Alali S. A., Curran L. The use of the ReDS noninvasive lung fluid monitoring system to assess readiness for discharge in patients hospitalized with acute heart failure: A pilot study. Heart Lung. 2021; 50(1): P.59–64. doi: 10.1016/j.hrtlng.2020.07.003.

20. Roy S., McCabe P., Karnes A., et al. Effect of the Remote Dielectric Sensing Vest on Reducing Heart Failure Admissions. Journal of Cardiac Failure. 2019; 205(8): S126. doi: 10.1016/j.cardfail.2019.07.360.

21. Olessen A. S., Miger K., Fabricius-Bjerre A., et al. Remote Dielectric Sensing to detect acute heart failure in patients with dyspnoea — a prospective observational study in the emergency department. European Heart Journal Open. 2022; 2(6): oeac073. doi: 10.1093/ehjopen/oeac073.

22. Volz E, Tordella M, Miller R, et al. ReDS vest use in the emergency department: identifying high risk heart failure patients. J Card Fail. 2019; 25(8S): S68–S69. doi: 10.1016/j.cardfail.2019.07.195.

23. Adatya S., Imamura T., Kim G.H., et al. Noninvasive Assessment of Lung Fluid Content in Heart Failure Patients. The Journal of Heart and Lung Transplantation. 2017; 36(4S): S213–S214. doi: 10.1016/j.healun.2017.01.561.

24. Offer Amir, Tuvia Ben-Gal, Jean Marc Weinstein, et al. Evaluation of remote dielectric sensing (ReDS) technology-guided therapy for decreasing heart failure re-hospitalizations. International Journal of Cardiology. 2017; 240: 279–284. doi: 10.1016/j.ijcard.2017.02.120.

25. Lala A., Barghash M. H., Giustino G., et al. Early use of remote dielectric sensing after hospitalization to reduce heart failure readmissions. ESC Heart Fail. 2021; 8(2): 1047–1054. doi: 10.1002/ehf2.13026.

26. Opsha Y., Zhuge P., Guevarra J., et al. Retrospective Evaluation of Remote Dielectric Sensing (ReDS) Vest Technology and its Impact on Heart Failure Readmission Rates and Diuretics Therapy. Journal of Cardiac Failure. 2019; 25(8): S147–S148. doi: 10.1016/j.cardfail.2019.07.424.

27. Mei F., Di Marco Berardino A., Bonifazi M., et al. Validation of Remote Dielectric Sensing (ReDS) in Monitoring Adult Patients Affected by COVID-19 Pneumonia. Diagnostics (Basel). 2021; 11(6): 1003. doi: 10.3390/diagnostics11061003.

28. Rejtblat O. M. The real experience of the chronic heart failure center: is there a place for innovation in it? Effective pharmacotherapy. 2023; 19(30): 60.