ЦИТИКОЛИН В РЕАБИЛИТАЦИИ ПОСТИНСУЛЬТНЫХ ПАЦИЕНТОВ
https://doi.org/10.20514/2226-6704-2013-0-5-48-51
Abstract
The problem of effective neuroprotection is one of the most actual till now. Administration citicoline for achieve neuronal membrane metabolism normalization was discussed according to evidence-based medicine. Results of metaanalyzes including safe use of citicoline in both oral and parenteral were showing same effects.
About the Author
С. В. Бабак
ФГАОУ ВПО «Балтийский федеральный университет им. И. Канта»
Russian Federation
лаборатория клинической фармакологии Инновационного парка, г. Калининград
Russian Federation
лаборатория клинической фармакологии Инновационного парка, г. Калининград
References
1. Ваизова О.Н., Заутнер Н.А. и др. Применение нейропротекторов при тяжёлых поражениях головного мозга // Бюллетень сибирской медицины. 2011. № 5. С. 36–40.
2. Зубарев К., Байдауз И. и др. Клиническая эффективность цитиколина в комплексном лечении постреанимационного синдрома // Международный неврологический журнал. 2011. №3 (41). С. 60–62.
3. Клюшников С.А. Нейропротективные и нейрорепаративные эффекты Цераксона (цитиколина): обзор экспериментальных и клинических исследований // Нервные болезни. 2012. № 3. С. 13–20.
4. Alberghina M., Giuffrida A.M. Effect of hypoxia on the incorporation of [2-3H] glycerol and [1-14C]-palmitate into lipids of various brain regions // J. Neurosci. Res. 1981. Vol. 6. P. 403–19.
5. Alberghina M., Viola M., Serra I., Mistretta A., Giuffrida A.M. Effect of CDP-choline on the biosynthesis of phospholipids in brain regions during hypoxic treatment // J. Neurosci. Res. 1981. Vol. 6. P. 421–433.
6. Boismare F., Le Poncin M., Lefrancois J., Lecordier J.C. Action of cytidine diphosphocholine on functional and hemodynamic effects of cerebral ischemia in cats // Pharmacology. 1978. Vol. 17. P. 15–20.
7. Boismare F., Le Poncin-Lafitte M., Rapin J.R. Effets hemodynamiques, fonctionelles et biochimiques de l’hypoxie hypobare chez le rat traite par la cytidine diphosphocholine //C. R. Seances Soc. Biol. Fil. 1978. Vol. 172. P. 651–658.
8. Cho H.J., Kim Y.J. Efficacy and safety of oral citicoline in acute ischemic stroke: drug surveillance study in 4,191 cases // Methods Find Exp. Clin. Pharmacol. 2009. Vol. 31. P. 171–176.
9. Clark W.M., Wechsler L.R., Sabounjian L.A., Schwiderski U.E. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients // Neurology. 2001. Vol. 57. P. 1595–602.
10. Farooqui A.A., Horrocks L.A., Farooqui T. Glycerophospholipids in brain: their metabolism, incorporation to membranes, functions, and involvement in neurological disorders // Chem. Phys. Lipids. 2000. Vol. 106. P. 1–29.
11. Hazama T., Hasegawa T., Ueda S., Sakuma A. Evaluation of the effect of CDP-choline on poststroke hemiplegia employing a doubleblind controlled trial. Assessed by a new rating scale for recovery in hemiplegia // Int. J. Neurosci. 1980. Vol. 11. P. 211–225/
12. http://www2.cochrane.org
13. Joo J.H., Jetten A.M. Molecular mechanisms involved in farnesolinduced apoptosis // Cancer Lett. 2010. Vol. 287. P. 123–135.
14. Kennedy E.P., Weiss S.B. The function of cytidine coenzymes in the biosynthesis of phospholipides// J. Biol. Chem. 1956. Vol. 222. P. 193–214.
15. Lozano R. La membrana neuronal: implicaciones terapeuticas // Boletin de Neurologia. 1993. Vol. 2. P. 3–8.
16. Ortega G., Jacas C., Quintana M., Ribo´ M., Santamarina E., Maisterra O., Molina C., Montaner J., Roman G., Alvarez-Sabín J. Citicoline treatment prevents neurocognitive decline after a first ischemic stroke // Cerebrovasc Dis. 2010. Vol. 29 (Suppl. 2). P. 268–288.
17. Saver J.L. Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair // Rev. Neurol. Dis. 2008. Vol. 5. P. 167–177.
18. Secades J.J. Citicoline: pharmacological and clinical review, 2010 update // Rev. Neurol. 2011. Vol. 52 (Suppl. 2). P. S1–S62.
19. Siesjo B.K. Cell damage in the brain caused by ischemia. An overview. In Krieglstein J., ed. Pharmacology of cerebral ischemia. Amsterdam: Elsevier Science Publishers, 1986. P. 3–11.
20. Tazaki Y. Treatment of acute cerebra infarction with a choline precursor in a multicenter double–blind placebo–controlled study // Stroke. 1988. Vol. 19. P. 211–216.
Review
For citations:
Бабак С.В. ЦИТИКОЛИН В РЕАБИЛИТАЦИИ ПОСТИНСУЛЬТНЫХ ПАЦИЕНТОВ. The Russian Archives of Internal Medicine. 2013;(5):48-51. (In Russ.) https://doi.org/10.20514/2226-6704-2013-0-5-48-51
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