Kikuchi-Fujimoto’s Disease on The Background of Primary Immunodeficiency and Multiple Sclerosis: A Clinical Case

E. V. Aranovich; V. A. Lisovoy; V. A. Fefelova; Э. В. Аранович; В. А. Лисовой; В. А. Фефелова

doi:10.20514/2226-6704-2026-16-4-305-311

Kikuchi-Fujimoto’s Disease on The Background of Primary Immunodeficiency and Multiple Sclerosis: A Clinical Case

E. V. Aranovich, V. A. Lisovoy, V. A. Fefelova

https://doi.org/10.20514/2226-6704-2026-16-4-305-311

EDN: RQFQUL

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Abstract

For the first time, a combination of Kikuchi-Fujimoto’s disease with general variable immune deficiency and multiple sclerosis has been described. The patient’s primary immunodeficiency, accompanied by frequent and severe exacerbations of chronic diseases, led to a protracted diagnostic search. The case highlights the importance of timely morphological examination in persistent lymphadenopathy, even in patients with known immune disorders.

Keywords

Kikuchi-Fujimoto’s disease, histiocytic necrotizing lymphadenitis, primary immunodeficiency, general variable immune deficiency, multiple sclerosis

About the Authors

E. V. Aranovich

Yusupov Hospital (LLC «Neuro-Clinic»)
Russian Federation

Elina V. Aranovich — Deputy General Director for Medical Work, Oncologist, Internist

Moscow

Competing Interests:

The authors declare no conflict of interests

V. A. Lisovoy

Yusupov Hospital (LLC «Neuro-Clinic»)
Russian Federation

Vyacheslav A. Lisovoy — Candidate of Medical Sciences, oncologist, surgeon

Moscow

Competing Interests:

The authors declare no conflict of interests

V. A. Fefelova

FSAEI of HE «RNRMU named after N.I. Pirogov of the Ministry of Health of the Russian Federation»
Russian Federation

Valeria A. Fefelova — resident doctor specializing in the therapy of propedeutics of Internal Medicine No. 2 of the Clinical Medicine Institute

Moscow

Competing Interests:

The authors declare no conflict of interests

References

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Review

For citations:

Aranovich E.V., Lisovoy V.A., Fefelova V.A. Kikuchi-Fujimoto’s Disease on The Background of Primary Immunodeficiency and Multiple Sclerosis: A Clinical Case. The Russian Archives of Internal Medicine. 2026;16(4):305-311. https://doi.org/10.20514/2226-6704-2026-16-4-305-311. EDN: RQFQUL

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