SUBCLINICAL LESION OF CAROTID ARTERIES IN CHRONIC GLOMERULONEPHRITIS
https://doi.org/10.20514/2226-6704-2017-7-4-300-305
Abstract
Purpose of the study. Examine gender characteristics of lesion of precerebral arteries and their relationship with renal dysfunction in patients with chronic glomerulonephritis at predialysis stage of the disease.Material and methods.The study included 306 patients with chronic glomerulonephritis aged 17 to 71 years. Group 1 — male (n = 210), group 2 — women (n = 96). All patients, in addition to general clinical testing methods, had noninvasive assessment of structural changes in precerebral arteries. Results and conclusion. In patients with chronic glomerulonephritis, structural changes in precerebral arteries are detected at predialysis stage and do not showsignificant difference depending on gender. Male individuals had
hypoproteinemia, subnephrotic proteinuria, clinically relevant hypertriglyceridemia and higher rates of precerebral arteries’ thickness, compared to female patients. At the same time, female individuals showed significantly worse parameters of peripheral blood and renal function, compared to male patients. Negative correlation between glomerular filtration rate and thickness of common and internal carotid artery was found both in general group and in individual male group. The results of the study suggest that in order to prevent vascular complications in the future, patients with chronic glomerulonephritis on the pre-dialysis stage of CKD need to study carotid arteries, as well as in a comprehensive analysis of renal function
About the Authors
I. T. Murkamilov
Kyrgyz State Medical Academy named after I.K. Akhunbaev, National Center for Cardiology and Therapy named after academician Mirsaid Mirrahimov
Russian Federation
Russian Federation
R. A. Aitbaev
Scientific and research Institute of molecular biology and medicine
Russian Federation
Russian Federation
V. V. Fomin
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
F. A. Yusupov
Osh state University
Russian Federation
Russian Federation
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Review
For citations:
Murkamilov I.T., Aitbaev R.A., Fomin V.V., Yusupov F.A. SUBCLINICAL LESION OF CAROTID ARTERIES IN CHRONIC GLOMERULONEPHRITIS. The Russian Archives of Internal Medicine. 2017;7(4):300-305. (In Russ.) https://doi.org/10.20514/2226-6704-2017-7-4-300-305
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