MORPHOLOGICAL CHANGES OF STRUCTURES OF CANALTS AND VASCULAR KIDNEY SYSTEMS WITH PROTEIN LOAD

Objective. Protein is an important component in the process of functioning of the body. But for those who have kidney disease, excessive consumption of protein, leads to the opposite effect. Since the glomeruli of blood vessels can not completely filter blood, toxic substances accumulate in the body. This leads to the disease of other organs. Therefore, the topic is important for research. The main goal of the work is to study the morphological changes in the structures of the tubular and vascular systems of the kidneys under protein loading. Regulation of protein homeostasis is provided by structural and functional systems and can be accompanied by proteinuria. Material and methods. Therefore, in order to study the structural bases of integration of functional kidney systems in the regulation of protein homeostasis, the author created a model for the disturbance of protein homeostasis in blood in rats. For the experiments, mature non-native white rats weighing 140-160 g were used, which were divided into three groups. Results. After the experiment, during the first day, the afferent and widening of the efferent arterioles, an increase in the percentage of glomeruli, was seen. The structure of the proximal tubule cells did not change. On the third day, the degree of opening of the blood capillaries, surface and juxtamadullar nephrons, exceeds the parameters of the control animals. As a result of the morphological study of the kidney, it was established that, under different physiological conditions, there are regular changes in the cells of the SOUTH and capillaries of the glomeruli of superficial and juxtamedullary nephrons, which are aimed at increasing the functional reserve of the kidneys in regulating protein homeostasis. Conclusion. It was established that a single protein load is accompanied by activation of the juxtaglomerular complex, a change in the functioning of the nephrons.

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