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Stroke in children and adolescents: topical problems of pre-hospital diagnostics

https://doi.org/10.20514/2226-6704-2020-10-1-21-30

Abstract

The article is devoted to the urgent problem of pediatrics and pediatric neurology, pre-hospital diagnosis of stroke in children. A review of domestic and foreign literature on the early diagnosis of stroke in children and adolescents, as well as epidemiological data on pediatric stroke, is presented. Particular attention is paid to the features of the symptoms of stroke and stroke-like conditions («stroke masks») in the pediatric population and the analysis of the main factors that influence errors in the early diagnosis of stroke in children and adolescents. Currently, in the diagnosis of ischemic stroke, its «masks» are found in 53.9 % of cases, with hemorrhagic stroke, in 36.3 %, and with transient ischemic attacks, in 9.8 % of cases. One of the most common diseases with which it is necessary to differentiate ischemic stroke in children is migraine. This problem is covered in academic writings that highlight the leading differential diagnostic criteria for migraine and stroke, and also represent a diagnostic algorithm. The clinical features of pediatric stroke, especially manifest symptoms, make it difficult to apply adult screening stroke scales in pediatrics. The article discusses the main scales for the early diagnosis of stroke in adults, and their potential application in pediatric practice. Currently accumulated experience in prehospital and early diagnosis of stroke in children determines the main directions of work to reduce the time of diagnosis of acute cerebrovascular accidents in children, followed by the introduction of reperfusion therapy in pediatric practice.

About the Authors

Y. A. Khachaturov
Morozov Children’s City Clinical Hospital of Moscow Healthcare Department
Russian Federation
Moscow


I. O. Shchederkina
Morozov Children’s City Clinical Hospital of Moscow Healthcare Department
Russian Federation
Moscow


N. F. Plavunov
First aid station named after A.S. Puchkov; Federal State Budget institution of Higher Education «A.I. Evdokimov Moscow State University of Medicine and Dentistry»
Russian Federation
Moscow


A. M. Sidorov
First aid station named after A.S. Puchkov; Federal State Budget institution of Higher Education «A.I. Evdokimov Moscow State University of Medicine and Dentistry»
Russian Federation
Moscow


E. E. Petryaykina
Morozov Children’s City Clinical Hospital of Moscow Healthcare Department; Peoples Friendship University of Russia
Russian Federation
Moscow


I. P. Vytkovskaya
Morozov Children’s City Clinical Hospital of Moscow Healthcare Department; Research Institute of Health Care Organization and Medical Management of Moscow Healthcare Department
Russian Federation
Moscow


V. A. Kadyshev
First aid station named after A.S. Puchkov; Federal State Budget institution of Higher Education «A.I. Evdokimov Moscow State University of Medicine and Dentistry»
Russian Federation

Valery A. Kadyshev

Moscow



References

1. Gordon A., Carr L., Ganesan V. et al. Outcome after stroke in childhood. In: Stroke and cerebrovascular disease in childhood. Eds. V. Ganesan, F. Kirkham, London: Mac Keith Press. 2011; 340-354.

2. Schoenberg B.S., Mellinger J.F., Schoenberg D.G. Cerebrovascular disease in infants and children: a study of incidence, clinical features and survival. Neurology. 1978; 28:763-8.

3. Giroud M., Lemesle M., Gouyon J.B. et al. Cerebrovascular disease in children under 16 years of age in the city of Dijon, France: a study of incidence and clinical features from 1985 to 1993. Journal of clinical epidemiology. 1995; 48(11):1343-8.

4. Agrawal N., Johnston S.C., Wu Y.W. et al. Imaging data reveal a higher pediatric stroke incidence than prior US estimates. Stroke. 2009; 40(11):3415-21. DOI: 10.1161/STROKEAHA.109.564633.

5. De Veber G.A., Kirton A., Booth F.A. et al. Epidemiology and outcomes of arterial ischemic stroke in children: the Canadian Pediatric Ischemic Stroke Registry. Pediatric neurology. 2017; 69:58-70. DOI: 10.1016/j.pediatrneurol.2017.01.016.

6. Steinlin M., Pfister I., Pavlovic J. et al. The first three years of the Swiss Neuropaediatric Stroke Registry (SNPSR): a population-based study of incidence, symptoms and risk factors. Neuropediatrics. 2005; 36(02):90-7. DOI: 10.1186/s40348-015-0026-2.

7. De Veber G.A. The epidemiology of childhood stroke. In: Stroke and cerebrovascular disease in childhood. Eds. V.Ganesan, F.Kirkham, London: Mac Keith Press; 2011; 69:22-6.

8. Lvova O.A., Kuznetsov N.N., Gusev V.V. Epidemiology and etiology of strokes in babies. Neurology, neuropsychiatry, psychosomatics. 2013; (S2):50-5. [in Russian]. DOI: http://dx.doi.org/10.14412/23101342-2013-2359

9. Jeong G., Lim B.C., Chae J.H. Pediatric stroke. Journal of Korean Neurosurgical Society. 2015; 57(6):396-400.

10. Rivkin M.J., Bernard T.J., Dowling M.M. et al. Guidelines for urgent management of stroke in children. Pediatric neurology. 2016; 56:8-17. DOI: 10.1016/j.pediatrneurol.2016.01.016.

11. Yock-Corrales A., Varela-Bulgarelli F., Barboza C. et al. Presentation of Acute childhood stroke in a tertiary pediatric emergency department. Pediatric emergency car. 2018; 34(8):552-7. DOI: 10.1097/PEC.0000000000000918.

12. Zykov V.P., Vasilev S.A., Komarova I.B. Ischemic stroke in childhood. Lechebnoe delo. 2009; 2: 12-20. [in Russian].

13. Federal guidelines for pediatric neurology /edited by Guzeva V.I. М: ООО «МК». 2016: 656 p. [in Russian].

14. Australian Childhood Stroke Advisory Committee. The Diagnosis and acute management of childhood stroke. Clinical guideline. 2017; 58 p.

15. Royal College of Paediatrics and Child Health (RCPCH), London. Sroke in children, clinical quideline for diagnosis, management and rehabilitation. 2017; 169 p.

16. Beslow L.A. Stroke Diagnosis in the Pediatric Emergency Department: An Ongoing Challenge. 2017; 48(5):1198-202. DOI: 10.1161/STROKEAHA.117.016868.

17. Whitehouse W.P., Agrawal S. Management of children and young people with headache. Archives of Disease in Childhood-Education and Practice. 2017; 102(2): 58-65. DOI: 10.1136/archdischild-2016-311803.

18. McGlennan C., Ganesan V. Delays in investigation and management of acute arterial ischaemic stroke in children. Developmental Medicine & Child Neurology. 2008; 50(7):537-40. DOI: 10.1111/j.1469-8749.2008.03012.x.

19. Srinivasan J., Miller S.P., Phan T.G. et al. Delayed recognition of initial stroke in children: need for increased awareness. Pediatrics. 2009; 124(2):227-34. DOI: 10.1542/peds.2008-3544.

20. Earley C.J., Kittner S.J., Feeser B.R. et al. Stroke in children and sicklecell disease: Baltimore-Washington cooperative young stroke study. Neurology. 1998; 51(1):169-76.

21. Mackay M.T., Churilov L., Donnan G.A. et al. Performance of bedside stroke recognition tools in discriminating childhood stroke from mimics. Neurology. 2016; 86(23):2154-61. DOI: 10.1212/WNL.0000000000002736.

22. Mackay M.T., Yock-Corrales A., Churilov L. et al. Differentiating childhood stroke from mimics in the emergency department. Stroke. 2016; 47(10):2476-81. DOI: 10.1161/STROKEAHA.116.014179.

23. Gonzalez M.J. & Yock-Corrales A. Stroke Mimics in the Pediatric Population. Neuro Open J. 2015; 2(3):74-8. DOI: 10.17140/NOJ2-116.

24. Bhate, S., & Ganesan, V.A. A practical approach to acute hemiparesis in children. Developmental Medicine & Child Neurology. 2015; 57(8):689-97. DOI: 10.1111/dmcn.12750.

25. Mackay M.T., Lee M., Yock-Corrales A. et al. Differentiating arterial ischaemic stroke from migraine in the paediatric emergency department. Developmental Medicine & Child Neurology. 2018; 60(11):1117-22. DOI: 10.1111/dmcn.13772.

26. Fullerton H.J., Wintermark M., Hills N.K. et al. Risk of recurrent arterial ischemic stroke in childhood: a prospective international study. Stroke. 2016; 47(1):53-9. DOI: 10.1161/STROKEAHA.115.011173.

27. Spalice A., Del Balzo F., Papetti L. et al. Stroke and migraine is there a possible comorbidity? Italian journal of pediatrics. 2016; 42(1):41. DOI: 10.1186/s13052-016-0253-8.

28. Gelfand A.A., Fullerton H.J., Jacobson A., et al. Is migraine a risk factor for pediatric stroke? Cephalalgia 2015; 35(14):1252-60. DOI: 10.1177/0333102415576222.

29. Aroor S., Singh R. & Goldstein L.B. BE-FAST (Balance, Eyes, Face, Arm, Speech, Time) Reducing the Proportion of Strokes Missed Using the FAST Mnemonic. Stroke. 2017; 48(2):479-81. DOI: 10.1161/STROKEAHA.116.015169.

30. Ichord R.N., Bastian R., Abraham L. et al. Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study. Stroke. 2011; 42(3):613–7. DOI: 10.1161/STROKEAHA.110.607192.

31. Mármol-Szombathy I., Domínguez-Durán E., Calero-Ramos L. et al. Identification of dizzy patients who will develop an acute cerebrovascular syndrome: a descriptive study among emergency department patients. European Archives of Oto-Rhino-Laryngology. 2018; 275(7):1709-13. DOI: 10.1007/s00405-018-4988-2.

32. Neville K., Lo W. Sensitivity and specificity of an adult stroke screening tool in childhood ischemic stroke. Pediatric neurology. 2016; 58:53-6. DOI: 10.1016/j.pediatrneurol.2016.02.001.

33. Srinivasan J., Miller S.P., Phan T.G. et al. Delayed recognition of initial stroke in children: need for increased awareness. Pediatrics. 2009; 124(2):227-34. DOI: 10.1542/peds.2008-3544.

34. Rafay M.F., Pontigon A.M., Chiang J. et al. Delay to diagnosis in acute pediatric arterial ischemic stroke. Stroke. 2009; 40(1):58-64. DOI: 10.1161/STROKEAHA.108.519066.

35. Stojanovski B., Monagle P.T., Mosley I. et al. Prehospital emergency care in childhood arterial ischemic stroke. Stroke. 2017; 48(4):1095-7. DOI: 10.1161/STROKEAHA.116.014768


Review

For citations:


Khachaturov Y.A., Shchederkina I.O., Plavunov N.F., Sidorov A.M., Petryaykina E.E., Vytkovskaya I.P., Kadyshev V.A. Stroke in children and adolescents: topical problems of pre-hospital diagnostics. The Russian Archives of Internal Medicine. 2020;10(1):21-30. https://doi.org/10.20514/2226-6704-2020-10-1-21-30

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ISSN 2226-6704 (Print)
ISSN 2411-6564 (Online)