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Ингибиторы протонной помпы в период пандемии COVID-19

https://doi.org/10.20514/2226-6704-2022-12-4-245-253

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Аннотация

Безопасность применения ингибиторов протонной помпы (ИПП) при коронавирусной инфекции (COVID-19) является недостаточно изученной. ИПП являются мощными супрессорами желудочной секреции и входят в десятку наиболее широко используемых препаратов в мире. Предполагается, что препараты влияют на восприимчивость к вирусу, тяжесть течения и исходы у пациентов с диагнозом COVID-19. Это беспокойство основано на механизме действия ИПП — подавлении кислотности желудочного сока, который считается первой линией защиты от инфекций. В совокупности результаты большинства исследований и метаанализов подтверждают возможность того, что использование ИПП может способствовать развитию более тяжелой формы COVID-19. Однако учесть все потенциальные факторы риска тяжести COVID-19 в реальной клинической практике представляется затруднительным, поэтому следует с большой осторожностью относиться к выводам о причинно-следственных связях применения ИПП. Дополнительная интересная точка зрения на использование ИПП во время пандемии заключается в том, что их прием может привести к снижению всасывания некоторых витаминов. С другой стороны, в литературе появилось несколько исследований в отношении защитных терапевтических эффектов ИПП. Все больше доказательств иммуномодулирующей и антифиброзной роли ИПП, что может быть использовано в лечении COVID-19. Кроме того, способность препаратов подщелачивать содержимое эндосом и лизосом служит препятствием для проникновения вируса в клетки. В представленном обзоре проанализированы возможные эффекты приема ИПП у пациентов с COVID-19.

Об авторах

Т. Е. Куглер
ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»
ДНР

Донецк

 



И. С. Маловичко
ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»
ДНР

Донецк



В. Б. Гнилицкая
ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»
ДНР

Донецк

 



А. Л. Христуленко
ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»
ДНР

Донецк

 



Н. Ф. Яровая
ГОО ВПО «Донецкий национальный медицинский университет им. М. Горького»
ДНР

Донецк



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Рецензия

Для цитирования:


Куглер Т.Е., Маловичко И.С., Гнилицкая В.Б., Христуленко А.Л., Яровая Н.Ф. Ингибиторы протонной помпы в период пандемии COVID-19. Архивъ внутренней медицины. 2022;12(4):245-253. https://doi.org/10.20514/2226-6704-2022-12-4-245-253

For citation:


Kugler T.E., Malovichko I.S., Gnilitskaya V.B., Khristulenko A.L., Yarovaya N.F. Proton Pump Inhibitors in the COVID-19 Pandemic. The Russian Archives of Internal Medicine. 2022;12(4):245-253. (In Russ.) https://doi.org/10.20514/2226-6704-2022-12-4-245-253

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ISSN 2226-6704 (Print)
ISSN 2411-6564 (Online)