Diagnosis and Clinical Significance of «Hidden» Spectral Disorders of Blood Oxygenation Among Smokers with Exacerbation of Bronchial Asthma
https://doi.org/10.20514/2226-6704-2023-13-1-75-80
Abstract
The purpose of the study — to identify and evaluate the clinical significance of “hidden” disorders of blood oxygenation in smokers with exacerbation of bronchial asthma.
Materials and methods: spirometry, pulse oximetry, CO-metry of exhaled air. To diagnose “hidden” disorders of blood oxygenation, including “hidden” violations of the spectral characteristics of the level of hemoglobin oxygen saturation, 19 male smokers (middle age 54,6±2,05 years) with exacerbation of mixed (68 %) or allergic (32 %) bronchial asthma were examined.
The results: the accuracy of the clinical assessment of blood oxygenation in smokers increased significantly after the correction of the SpO2 level to the level of carboxyhemoglobin with the help of a computer program developed by us, which made it possible to diagnose a clinically significant lifethreatening exacerbation of this disease in smoking patients with bronchial asthma, since “hidden” respiratory insufficiency was detected in a timely manner.
About the Authors
V. V. GnoevykhRussian Federation
Valery V. Gnoevykh
Ulyanovsk
Competing Interests:
The authors declare no conflict of interests
Yu. A. Shorokhova
Russian Federation
Ulyanovsk
Competing Interests:
The authors declare no conflict of interests
A. Yu. Smirnova
Russian Federation
Ulyanovsk
Competing Interests:
The authors declare no conflict of interests
E. V. Efremova
Russian Federation
Ulyanovsk
Competing Interests:
The authors declare no conflict of interests
References
1. Jarvis M.J. Russel M.A., Saloojee Y. Expired air carbon monoxide: a simple breath test of tobacco smoke intake. BMJ. 1980; 281 (16): 484-495.DOI: 10.1136/bmj.281.6238.484.
2. West J.B. Respiratory Physiology: The Essentials (eighth edition). J.B. West: England. 2013; 150p.
3. Fatkullin K.V., Gilmanov A.Zh., Kostyukov D.V. Clinical significance and modern methodological aspects of determining the level of carboxy- and methemoglobin in the blood. Practical medicine. 2014; 3(14): 17-21. [In Russian].
4. Cerveri I. The impact of cigarette smoking on asthma: a populationbased international cohort study. Int. Arch. Allergy Immunol. 2012; 2(158): 75–183. DOI: 10.1159/000330900.
5. Titova O., Kozyrev A., Sukhovskaya O. The influence of various risk factors on the course and prognosis of bronchial asthma. Doctor. 2013; (6): 85-87. [In Russian].
6. Global Initiative for Asthma, GINA. 2022, 225р [Electronic resource]. URL: https://ginasthma.org/wp-content/uploads/2022/07/GINA-Main-Report-2022-FINAL-22-07-01-WMS.pdf (date of the application: 05.09.2022).
7. Clinical recommendations on bronchial asthma recommendations from the Ministry of Health. 2021; 85 р. [Electronic resource] URL: http://disuria.ru/_ld/10/1037_kr21J45J46MZ.pdf?ysclid=l7un7hzve9180338084 (дата обращения 05.09.2022). [In Russian].
8. Barker S.J., Tremper K.K. The effect of carbon monoxide inhalation on pulse oximeter signal detection. Anesthesiology. 1987; (67): 599-603. DOI: 10.1097/00000542-198705000-00014.
9. WHO Guidelines on pulse oximetry. 2009; 23 р. [Electronic resource] URL: https://mayak.help/wp-content/uploads/2016/05/WHO-Pulse-Oximetry-Training-Manual-Final-Russian.pdf (date of the application: 24.01.2021) [In Russian].
10. Wilson Iain. Pulse oximetry — Part 1/I. Wilson. Anaesthesia Tutorial Of The Week 123,-2nd March. 2009: 1-7р.
11. Buckley R.G., Aks S.E., Eshom J.L. et al. The pulse oximetry gap in carbon monoxide intoxication. Ann Emerg Med. 1994; (24): 252–255.
12. Gorge A. Guzman. Carbon Monoxide Poisoning. Critical Care Clinics. 2012; 28(4): 537-548.
13. Buzunov R.V., Ivanova I.L., Kononov Yu.L. et al. Computer pulse oximetry in the diagnosis of breathing disorders during sleep. Izhevsk, 2013; 40 р. [In Russian].
14. Clinical recommendations of the association of clinical toxicologists “Toxic effect of carbon monoxide. Toxic effects of other gases, fumes and vapours”. 2020; 40 р. [Electronic resource] URL: http://www.toxicology.ru/docs/rek/09_26112020.pdf (date of the application: 20.07.2022) [In Russian].
Review
For citations:
Gnoevykh V.V., Shorokhova Yu.A., Smirnova A.Yu., Efremova E.V. Diagnosis and Clinical Significance of «Hidden» Spectral Disorders of Blood Oxygenation Among Smokers with Exacerbation of Bronchial Asthma. The Russian Archives of Internal Medicine. 2023;13(1):75-80. https://doi.org/10.20514/2226-6704-2023-13-1-75-80