АРТЕРИАЛЬНА Я ГИПЕРТОНИЯ У БОЛЬНЫХ ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЁГКИХ — В ПОИСКАХ ФЕНОТИПОВ. ЧАСТЬ I

Chronic obstructive pulmonary disease (COPD) is associated with important chronic comorbid diseases. Arterial hypertension (AH) is one of the most frequently occurring comorbidity in COPD. This study was conducted to assess clinical, functional and pathophysiological characteristics in patients with co-existing COPD and AH and in COPD and hypertensive patients. Marked differences have been found among groups. These results suggest that there is a subset of COPD patients with comorbid AH who may represent a distinct phenotype.

1. Anderson W., Lipworth B., Rekhraj S. et al. Left Ventricular Hypertrophy in Chronic Obstructive Pulmonary Disease without Hypoxaemia: The Elephant in the Room? Chest 2012; Jul 10. doi:10.1378/chest.12-0775.

2. Bhattacharyya P., Acharjee D., Ray S. et al. Left ventricular diastolic dysfunction in COPD may manifest myocardial ischemia. COPD 2012 ; 9(3): 305-309.

3. Burgel P-R., Paillasseur J-L, Caillaud D. et al. Clinical COPD phenotypes: a novel approach using principal component and cluster analyses. Eur Respir J 2010; 36: 531– 539.

4. Casanova C., de Torres J., Navarro J. et al. Microalbuminuria and Hypoxemia in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2010; 182: 1004-1010.

5. Chandra D., Stamm J., Palevsky P. et al. The Relationship Between Pulmonary Emphysema and Kidney Function in Smokers. Chest 2012; 142(3): 655–662.

6. Сrisafulli E., Gorgone P., Vagaggini B. et al. Efficacy of standard rehabilitation in COPD outpatients with comorbidities. Eur Respir J 2010; 36: 1042–1048.

7. Fabbri L.M., Luppi F., Beghe B. et al. Complex chronic comorbidities of COPD. Eur Respir J 2008; 31: 204–212.

8. Funk G-C., Lang I., Schenk P. et al. Left Ventricular Diastolic Dysfunction in Patients With COPD in the Presence and Absence of Elevated Pulmonary Arterial Pressure. Chest 2008; 133 (6 ): 1354-1359.

9. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (revised 2011). www.goldcopd.com.

10. Gupte S., Wolin M. Relationships between vascular oxygen sensing mechanisms and Hypertensive Disease processes. Hypertension 2012; 60: 269 – 275.

11. Han M.K., Agusti A., Calverley P.M. et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med 2010; 182 ( 5 ): 598 – 604.

12. Mannino D.M., Thorn D , Swensen A. et al. Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. Eur Respir J 2008 ; 32 ( 4 ): 962 – 969.

13. Nobili A., Garattini S., Mannucci P. Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium. Journal of Comorbidity 2011; 1: 28–44.

14. Rothwell P., Howard S.C., Dolan E. et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet 2010; 375: 895–905.

15. Valderas J., Mercer S., Fortin M. Research on patients with multiple health conditions: different constructs, different views, one voice. Journal of Comorbidity 2011; 1: 1–3.