ДИСФУНКЦИЯ ПЕЧЕНИ У КАРДИОХИРУРГИЧЕСКИХ БОЛЬНЫХ В РАННЕМ ПОСЛЕОПЕРАЦИОННОМ ПЕРИОДЕ
https://doi.org/10.20514/2226-6704-2014-0-1-50-54
Abstract
We investigate the frequency and reasons of liver dysfunction in the early postoperative period at patients after heart surgery. The liver dysfunction occurred at 120 from 663 (18%) operated patients in the early postoperative period. We revealed a distinct connection between a type of a surgery performed and liver dysfunction, which more frequently followed multivalve procedures and combined operative treatment like valve reconstruction and myocardial revascularization. Amongst causes, which contribute liver dysfunction we sorted 5 main ones: prolonged hypoxia in preoperative term, trauma due to surgery and intraoperative hypoxia, toxic medications, reactivation of a viral hepatitis, sepsis. A term, when liver dysfunction advances, depends on these causes.
About the Authors
О. В. СоколоваRussian Federation
г. Москва
В. П. Тюрин
Russian Federation
г. Москва
References
1. Козлов В.К. Ишемический септический гепатит. В кн: Сепсис. Этиология, иммуннопатогенез, концепция современной иммунотерапии // http: www. Fam-poland.com/2007.
2. Мишнеев О.Д., Щёголев А.Н., Трусов О.А. Патологоанатомическая диагностика сепсиса. В кн: Сепсис в начале ХХI века. Под ред. В.С. Савельева, Б.Р. Гельфанда. М: Литтерра, 2006. С. 139–172.
3. Шевченко Ю.Л., Гороховатский Ю.И., Азизова О.А., Замятин М.Н. Системный воспалительный ответ при экстремальной хирургической агрессии. Издание РАЕН, 2009.
4. Шульпекова Ю.О. Лекарственные поражения печени // Гастроэнтерология. Приложение к журналу Consilium medicum. 2007. № 1. С. 16–22.
5. Bohmer T., Kjekshus E., Nitter-Hauge S. Studies on the elimination of bilirubin pre-operatively in patients with mitral valve disease // Eur. Heart J. 1994. Vol.15. P. 10–16.
6. Carden D.L., Granger D.N. Pathophysiology of ischaemia-perfusion injury // J. Pathol. 2000. Vol. 190, № 3. P. 255–266.
7. Chu C.M., Chang C.H., Liaw Y.F., Hsieh M.J. Jaundice after open heart surgery: a prospective study // Thorax. 1984. Vol. 39. P. 52–56.
8. Clemmesen J.O., Hoy C.E., Jeppesen P.B. et al. Plasma phospholipid fatty acid pattern in severe liver disease // J. Hepatol. 2000. Vol. 32, № 3. P. 481–487.
9. Hayashida N., Shoujima T., Teshima H., Yokokura Y., Takagi K., Tomoeda H. et al. Clinical outcome after cardiac operations in patients with cirrhosis // Ann. Thorac. Surg. 2004. Vol. 77. P. 500–505.
10. Klepetko W., Miholic J. Jaundice after open heart surgery: a prospective study // Thorax. 1985. Vol. 40. P. 80–85.
11. Rivers E., Nguyen B., Havstad S. Early goal-directed therapy in the treatment of severe sepsis and septic shock // N. Engl. J. Med. 2001. Vol. 345. P. 1368–1377.
12. Sanderson R.G., Ellison J.H., Benson J.A. Jr, Starr A. Jaundice following open-heart surgery // Ann. Surg. 1967. Vol. 165. P. 217–224.
13. Suman A., Barnes D.S., Zein N.N., Levinthal G.N., Connor J.T., Carey W.D. Predicting outcome after cardiac surgery in patients with cirrhosis: a comparison of Child-Pugh and MELD scores // Clin. Gastroenterol. Hepatol. 2004. Vol. 2. P. 719–723.
14. Wang M.J., Chao A., Huang C.H., Tsai C.H., Lin F.Y., Wang S.S. et al. Hyperbilirubinemia after cardiac operation. Incidence, risk factors, and clinical significance // J. Thorac. Cardiovasc. Surg. 1994. Vol. 10. P. 429–436.
Review
For citations:
Соколова О.В., Тюрин В.П. ДИСФУНКЦИЯ ПЕЧЕНИ У КАРДИОХИРУРГИЧЕСКИХ БОЛЬНЫХ В РАННЕМ ПОСЛЕОПЕРАЦИОННОМ ПЕРИОДЕ. The Russian Archives of Internal Medicine. 2014;(1):50-54. (In Russ.) https://doi.org/10.20514/2226-6704-2014-0-1-50-54