COMPLEX APPROACHES TO TREATMENT OF DYSLIPIDEMIA IN PATIENTS WITH ISHEMIC HEART DISEASE
https://doi.org/10.20514/2226-6704-2015-0-5-16
Abstract
The risk of coronary heart disease increases significantly with an increase in blood cholesterol and low density lipoprotein (LDL). We know that is not always standard therapy fails to achieve target numbers of blood lipids in patients with coronary artery disease. We examined 100 patients with coronary heart disease (CHD): stable angina II-III functional — study group (60 patients) and control group (40 patients). The studies we have obtained evidence that the combination of plasmapheresis, ultraviolet blood irradiation and statins to reduce total cholesterol in patients IIFK 2,7% IIIFK 23,3%, LDL cholesterol in patients IIFK 30,4%, IIIFK 37,3% (r<0,05). Following the combination therapy achieved level of hyperlipidemia can be maintained with lower doses of statins.
About the Authors
M. A. Chichkova
Astrakhan State Medical University, the Ministry of Health of Russia
Russian Federation
Astrakhan
Russian Federation
Astrakhan
O. Sh. Oynotkinova
Astrakhan State Medical University, the Ministry of Health of Russia
Russian Federation
Astrakhan
Russian Federation
Astrakhan
N. V. Kovalenko
Astrakhan State Medical University, the Ministry of Health of Russia
Russian Federation
Astrakhan
Russian Federation
Astrakhan
A. A. Abdulkerimova
Astrakhan State Medical University, the Ministry of Health of Russia
Russian Federation
Astrakhan
Russian Federation
Astrakhan
M. U. Chichkov
Astrakhan State Medical University, the Ministry of Health of Russia
Russian Federation
Astrakhan
Russian Federation
Astrakhan
V. N. Mescheryakov
Astrakhan State Medical University, the Ministry of Health of Russia
Astrakhan
Astrakhan
References
1. Zhilyaeva Y.A., Mihin V.P., Zhilyaeva O.A. State parameters of lipid peroxidation and the elastic properties of the blood vessel wall in patients with coronary heart disease during therapy of generic statins. Kursk. scientific and practical. Vestnik. "Man and his health." 2013; 4: 66-72.
2. Karpov Y.A. Treatment of patients with stable angina: the exit of new recommendations VNOK. Russian Medical Journal. 2008; 21: 1379-1384.
3. National clinical guidelines. Collection. Under. Ed. RG Oganov. 3rd edition. M.: Publishing house " Silitseya - Polygraph ", 2010. 568.
4. Oynotkinova O.Sh. Combined therapy with statins and ursodeoxycholic acid in patients with coronary heart disease and non-insulin dependent diabetes mellitus. Proceedings of the V National Congress of Physicians. AM 000 "The publishing house" Bionics" 2010: 324.
5. Pristrom A.M., Samokhodkina S.V., Crater M.L. et al. Comparative efficacy and safety of Merten ( rosuvastatin ) in patients with hyperlipidemia. Med. news. 2013; 3: 51-56.
6. Khukhrev A.L., Shklovsky B.L., Oynotkinova O.Sh. Evaluation of clinical and metabolic characteristics of patients with coronary heart disease in combination with insulin- dependent diabetes mellitus undergoing coronary artery bypass grafting. Military Medical Journal, 2011; 4: 73-74.
7. Lablanche J.M., Danchin N., Farnier M. et al. Effects of rosuvastatin and atorvastatin on the apolipoprotein B/apolipoprotein A-1 ratio in patients with an acute coronary syndrome: The CENTAURUS trial design. Arch. Cardiovasc. Dis. 2008; 101: 399–406.
8. García Rodríguez L.A., Herings R., Johansson S. Use of multiple international healthcare databases for the detection of rare drug-associated outcomes: a pharmacoepidemiological programme comparing rosuvastatin with other marketed statins. Pharmacoepidemiol. Drug Saf. 2010; 19(12): 1218–1224.
9. Guidelines on the management of stable angina pectoris: executive summary. The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur. Heart J. 2006; 27(11): 1341-1381.
10. Kannel W.B., Plehn J.F., Cupples L.A. Cardiac failure and sudden death in the Framingham Study. Am. Heart J. 1988; 115(4): 869-875.
11. Linsel-Nitschke P., Samani N.J., Schunkert H.N. Sorting out cholesterol and coronary artery disease. Engl. J. Med. 2010; 363: 2462-2463.
12. Spagnoli L.G., Bonanno E., Sangiorgi G., Mauriello A. Role of Inflammation in Atherosclerosis. J. Nucl. Med. 2007; 48: 1800–1815.
Review
For citations:
Chichkova M.A., Oynotkinova O.Sh., Kovalenko N.V., Abdulkerimova A.A., Chichkov M.U., Mescheryakov V.N. COMPLEX APPROACHES TO TREATMENT OF DYSLIPIDEMIA IN PATIENTS WITH ISHEMIC HEART DISEASE. The Russian Archives of Internal Medicine. 2015;(5):45-48. (In Russ.) https://doi.org/10.20514/2226-6704-2015-0-5-16
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