ЛИМФОПЕНИЯ: ОСНОВНЫЕ ПРИЧИНЫ РАЗВИТИЯ
Аннотация
В обзоре представлены современные данные литературы об основных причинах развития лимфопении. Описаны наследственные иммунодефицитные состояния, инфекционные и аутоиммунные заболевания, злокачественные опухоли, лекарственные препараты и другая патология, при которой наблюдается снижение уровня лимфоцитов.
Об авторах
Н. Т. Ватутин
Донецкий национальный медицинский университет им. М. Горького;
Институт неотложной и восстановительной хирургии им. В.К. Гусака
Россия
Россия
кафедра внутренней медицины № 1,
Донецк
Е. В. Ещенко
Донецкий национальный медицинский университет им. М. Горького
Россия
Россия
кафедра внутренней медицины № 1,
Донецк
Список литературы
1. Барсуков В.Ю., Чеснокова Н.П., Зяблов Е.В., Селезнева Т.Д. Рак щитовидной железы: патофизиологические и клинические аспекты. М.: Акад. Естествознания. 2012; 104 с.
2. Ватутин Н.Т., Калинкина Н.В., Склянная Е.В. и соавт. Гематология. Донецк: Каштан, 2012; 346 с.
3. Al-Aska A., Al-Anazi A.R., Al-Subaei S.S. et al. CD4+ T-lymphopenia in HIV negative tuberculous patients at King Khalid University Hospital in Riyadh, Saudi Arabia. Eur. J. Med. Res. 2011; 16(6): 285-288.
4. Aoki A., Ohno S., Ueda A. et al. Hematological abnormalities of primary Sjogren’s syndrome. Nihon Rinsho Meneki Gakkai Kaishi. 2000; 23(2): 124-128.
5. Bakken J.S., Aguero-Rosenfeld M.E., Tilden R.L. et al. Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. Clin. Infect. Dis. 2001; 32(6): 862-870.
6. Barlow Y. T lymphocytes and immunosuppression in the burned patient: a review. Burns. 1994; 20(6): 487-490.
7. Bashal F. Hematological disorders in patients with systemic lupus erythematosus. Open Rheumatol. J. 2013; 7: 87-95.
8. Bordin G., Ballaré M., Paglino S. et al. Idiopathic CD4+ lymphocytopenia and systemic vasculitis. J. Intern. Med. 1996; 240(1): 37-41.
9. Chan P.K., Chen G.G. Mechanisms of lymphocyte loss in SARS coronavirus infection. Hong Kong Med. J. 2008; 14 (Suppl 4): 21-26.
10. de Jager C.P., Gemen E.F., Leuvenink J. et al. Dynamics of peripheral blood lymphocyte subpopulations in the acute and subacute phase of Legionnaires’ disease. PLoS One. 2013; 8(4): e62265.
11. de Jager C.P., van Wijk P.T., Mathoera R.B. et al. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit. Care. 2010; 14(5): R192.
12. de Vries R.D., McQuaid S., van Amerongen G. et al. Measles immune suppression: lessons from the macaque model. PLoS Pathog. 2012; 8(8): e1002885.
13. Fernández-Fresnedo G., Ramos M.A., González-Pardo M.C. et al. B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. Nephrol. Dial. Transplant. 2000; 15: 502–510.
14. Fox A., Le N.M., Horby P. et al. Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses. PLoS One. 2012; 7(2): e31535.
15. Freeman H.J., Nimmo M. Intestinal lymphangiectasia in adults. World J. Gastrointest. Oncol. 2011; 3(2): 19-23.
16. Garcia-Valladares I., Atisha-Fregoso Y., Richaud-Patin Y. et al. Diminished expression of complement regulatory proteins (CD55 and CD59) in lymphocytes from systemic lupus eyrthematosus patients with lymphopenia. Lupus. 2006; 15: 600-605.
17. Hepburn A.L., Narat S., Mason J.C. The management of peripheral blood cytopenias in systemic lupus erythematosus. Rheumatology (Oxford). 2010; 49(12): 2243-2254.
18. Hotchkiss R.S., Karl I.E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 2003; 348(2): 138-150.
19. Hug A., Korporal M., Schroder I. et al. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis. J. Immunol. 2003; 171: 432–437.
20. Izzedine H., Cacoub P., Launay-Vacher V. et al. Lymphopenia in Wegener’s granulomatosis. A new clinical activity index? Nephron. 2002; 92(2): 466-471.
21. Jauréguiberry S., Roussel M., Brinchault-Rabin G. et al. Clinical presentation of leptospirosis: a retrospective study of 34 patients admitted to a single institution in metropolitan France. Clin. Microbiol. Infect. 2005; 11(5): 391-394.
22. Kalman L., Lindegren M.L., Kobrynski L. et al. Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review. Genet. Med. 2004; 6(1): 16-26.
23. Liem N.T., Tung C.V., Hien N.D. et al. Clinical features of human influenza A (H5N1) infection in Vietnam: 2004-2006. Clin. Infect. Dis. 2009; 48(12): 1639-1646.
24. Mociková H. Prognostic significance of absolute lymphocyte count and lymphocyte subsets in lymphomas. Prague Med. Rep. 2010; 111(1): 5-11.
25. Nakayama G., Morioka D., Murakami T. et al. Chylous ascites occurring after low anterior resection of the rectum successfully treated with an oral fat-free elemental diet. Clin. J. Gastroenterol. 2012; 5(3): 216-219.
26. Nowak K., Wierzbicka M., Szyfter W. Chylous leakage--rare but still dangerous complication after neck surgery. Otolaryngol. Pol. 2011; 65(2): 128-131.
27. Pahl M.V., Gollapudi S., Sepassi L. et al. Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrol. Dial. Transplant. 2010; 25(1): 205–212.
28. Parinitha S., Kulkarni M. Haematological changes in HIV infection with correlation to CD4 cell count. Australas. Med. J. 2012; 5(3): 157-162.
29. Piliero L.M., Sanford A.N., McDonald-McGinn D.M. et al. T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome. Blood. 2004; 103(3): 1020-1025.
30. Ramos-Casals M., Brito-Zerón P., Solans R. et al. Systemic involvement in primary Sjogren’s syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry). Rheumatology (Oxford). 2014; 53(2): 321-331.
31. Roe M.F., Bloxham D.M., White D.K. et al. Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis. Clin. Exp. Immunol. 2004; 137(1): 139-145.
32. Sebnem Kilic S., Bostan O., Cil E. Takayasu arteritis. Ann. Rheum. Dis. 2002; 61(1): 92-93.
33. Shao L., Fujii H., Colmegna I. et al. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J. Exp. Med. 2009; 206(6): 1435–1449.
34. Shen H., Li B., Bai B. et al. Laboratory features throughout the disease course of influenza A (H1N1) virus infection. Clin. Lab. 2013; 59(3-4): 337-342.
35. Spencer D.C., Pienaar N.L., Atkinson P.M. Disturbances of blood coagulation associated with Salmonella typhi infections. J. Infect. 1988; 16(2): 153-161.
36. Sweiss N.J., Salloum R., Gandhi S. et al. Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PLoS One. 2010; 5(2): e9088.
37. Tan E.M., Cohen A.S., Fries J.F. et al. Tan ACR classification. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982; 25: 1271–1277.
38. Taxonera C., Mendoza J.L., Ortega L. et al. Adalimumab reversed a severe lymphopenia in a patient with Crohn’s disease. J. Crohns Colitis. 2012; 6(4): 488-491.
39. Tillipman Ladinsky H., Gillispie M., Sriaroon P., Leiding J.W. Thoracic duct injury resulting in abnormal newborn screen. J. Allergy Clin. Immunol. Pract. 2013; 1(6): 583-588.
40. Vaziri N.D., Pahl M.V., Crum A., Norris K. Effect of uremia on structure and function of immune system. J. Ren. Nutr. 2012; 22(1): 149-156.
41. Vignes S., Bellanger J. Primary intestinal lymphangiectasia (Waldmann’s disease). Orphanet J. Rare Dis. 2008; 3: 5.
42. Wiwanitkit V. Lymphopenia in severe acute respiratory syndrome: a summary on its frequency. Nepal. Med. Coll. J. 2007; 9(2): 132-133.
43. Yoon J., Gollapudi S., Pahl M., Vaziri N. Naïve and Central Memory T-cell lymphopenia in end-stage renal disease. Kidney Int. 2006; 70: 371–376.
44. Zhang J., Zhao Y., Chen Y. Laboratory findings in patients with avian-origin influenza A (H7N9) virus infections. J. Med. Virol. 2014; 86(5): 895-898.
45. Zheng P., Chang X., Lu Q., Liu Y. Cytopenia and Autoimmune Diseases: a Vicious Cycle fueled by mTOR Dysregulation in Hematopoietic Stem Cells. J. Autoimmun. 2013; 41: 182–187.
46. Zonios D.I., Falloon J., Bennett J.E. et al. Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors. Blood. 2008; 112(2): 287–294.
Для цитирования:
Ватутин Н.Т., Ещенко Е.В. ЛИМФОПЕНИЯ: ОСНОВНЫЕ ПРИЧИНЫ РАЗВИТИЯ. Архивъ внутренней медицины. 2016;6(2):22-27. https://doi.org/10.20514/2226-6704-2016-6-2-22-27
For citation:
Vatutin N.T., Yeshchenko Y.V. LYMPHOPENIA: THE MAIN CAUSES. The Russian Archives of Internal Medicine. 2016;6(2):22-27. (In Russ.) https://doi.org/10.20514/2226-6704-2016-6-2-22-27
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