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LYMPHOPENIA: THE MAIN CAUSES

https://doi.org/10.20514/2226-6704-2016-6-2-22-27

Abstract

This review presents recent data on the main causes of lymphopenia. Hereditary immunodeficiency, infectious and autoimmune diseases, malignant tumors, medications, and other conditions when the level of lymphocytes decreases are reviewed.

Keywords


About the Authors

N. T. Vatutin
M. Gorky Donetsk National Medical University; Institute of Urgent and Recovery Surgery named after V.K. Gusak
Russian Federation

Department of Internal Medicine № 1, 

Donetsk



Y. V. Yeshchenko
M. Gorky Donetsk National Medical University
Russian Federation

Department of Internal Medicine № 1, 

Donetsk



References

1. Barsukov V.Yu., Chesnokova N.P., Zyablov E.V., Selezneva T.D. Thyroid Cancer: pathophysiological and clinical aspects. M: Acad. Natural Science. 2012; 104 p.

2. Vatutin N.T., Kalinkina N.V., Sklyanna O.V. et al. Hematology. Donetsk: Kashtan, 2012; 346 p.

3. Al-Aska A., Al-Anazi A.R., Al-Subaei S.S. et al. CD4+ T-lymphopenia in HIV negative tuberculous patients at King Khalid University Hospital in Riyadh, Saudi Arabia. Eur. J. Med. Res. 2011; 16(6): 285-288.

4. Aoki A., Ohno S., Ueda A. et al. Hematological abnormalities of primary Sjogren's syndrome. Nihon Rinsho Meneki Gakkai Kaishi. 2000; 23(2): 124-128.

5. Bakken J.S., Aguero-Rosenfeld M.E., Tilden R.L. et al. Serial measurements of hematologic counts during the active phase of human granulocytic ehrlichiosis. Clin. Infect. Dis. 2001; 32(6): 862-870.

6. Barlow Y. T lymphocytes and immunosuppression in the burned patient: a review. Burns. 1994; 20(6): 487-490.

7. Bashal F. Hematological disorders in patients with systemic lupus erythematosus. Open Rheumatol. J. 2013; 7: 87-95.

8. Bordin G., Ballaré M., Paglino S. et al. Idiopathic CD4+ lymphocytopenia and systemic vasculitis. J. Intern. Med. 1996; 240(1): 37-41.

9. Chan P.K., Chen G.G. Mechanisms of lymphocyte loss in SARS coronavirus infection. Hong Kong Med. J. 2008; 14 (Suppl 4): 21-26.

10. de Jager C.P., Gemen E.F., Leuvenink J. et al. Dynamics of peripheral blood lymphocyte subpopulations in the acute and subacute phase of Legionnaires' disease. PLoS One. 2013; 8(4): e62265.

11. de Jager C.P., van Wijk P.T., Mathoera R.B. et al. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit. Care. 2010; 14(5): R192.

12. de Vries R.D., McQuaid S., van Amerongen G. et al. Measles immune suppression: lessons from the macaque model. PLoS Pathog. 2012; 8(8): e1002885.

13. Fernández-Fresnedo G., Ramos M.A., González-Pardo M.C. et al. B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. Nephrol. Dial. Transplant. 2000; 15: 502–510.

14. Fox A., Le N.M., Horby P. et al. Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses. PLoS One. 2012; 7(2): e31535.

15. Freeman H.J., Nimmo M. Intestinal lymphangiectasia in adults. World J. Gastrointest. Oncol. 2011; 3(2): 19-23.

16. Garcia-Valladares I., Atisha-Fregoso Y., Richaud-Patin Y. et al. Diminished expression of complement regulatory proteins (CD55 and CD59) in lymphocytes from systemic lupus eyrthematosus patients with lymphopenia. Lupus. 2006; 15: 600-605.

17. Hepburn A.L., Narat S., Mason J.C. The management of peripheral blood cytopenias in systemic lupus erythematosus. Rheumatology (Oxford). 2010; 49(12): 2243-2254.

18. Hotchkiss R.S., Karl I.E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 2003; 348(2): 138-150.

19. Hug A., Korporal M., Schroder I. et al. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis. J. Immunol. 2003; 171: 432–437.

20. Izzedine H., Cacoub P., Launay-Vacher V. et al. Lymphopenia in Wegener's granulomatosis. A new clinical activity index? Nephron. 2002; 92(2): 466-471.

21. Jauréguiberry S., Roussel M., Brinchault-Rabin G. et al. Clinical presentation of leptospirosis: a retrospective study of 34 patients admitted to a single institution in metropolitan France. Clin. Microbiol. Infect. 2005; 11(5): 391-394.

22. Kalman L., Lindegren M.L., Kobrynski L. et al. Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review. Genet. Med. 2004; 6(1): 16-26.

23. Liem N.T., Tung C.V., Hien N.D. et al. Clinical features of human influenza A (H5N1) infection in Vietnam: 2004-2006. Clin. Infect. Dis. 2009; 48(12): 1639-1646.

24. Mociková H. Prognostic significance of absolute lymphocyte count and lymphocyte subsets in lymphomas. Prague Med. Rep. 2010; 111(1): 5-11.

25. Nakayama G., Morioka D., Murakami T. et al. Chylous ascites occurring after low anterior resection of the rectum successfully treated with an oral fat-free elemental diet. Clin. J. Gastroenterol. 2012; 5(3): 216-219.

26. Nowak K., Wierzbicka M., Szyfter W. Chylous leakage--rare but still dangerous complication after neck surgery. Otolaryngol. Pol. 2011; 65(2): 128-131.

27. Pahl M.V., Gollapudi S., Sepassi L. et al. Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression. Nephrol. Dial. Transplant. 2010; 25(1): 205–212.

28. Parinitha S., Kulkarni M. Haematological changes in HIV infection with correlation to CD4 cell count. Australas. Med. J. 2012; 5(3): 157-162.

29. Piliero L.M., Sanford A.N., McDonald-McGinn D.M. et al. T-cell homeostasis in humans with thymic hypoplasia due to chromosome 22q11.2 deletion syndrome. Blood. 2004; 103(3): 1020-1025.

30. Ramos-Casals M., Brito-Zerón P., Solans R. et al. Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry). Rheumatology (Oxford). 2014; 53(2): 321-331.

31. Roe M.F., Bloxham D.M., White D.K. et al. Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis. Clin. Exp. Immunol. 2004; 137(1): 139-145.

32. Sebnem Kilic S., Bostan O., Cil E. Takayasu arteritis. Ann. Rheum. Dis. 2002; 61(1): 92-93.

33. Shao L., Fujii H., Colmegna I. et al. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J. Exp. Med. 2009; 206(6): 1435–1449.

34. Shen H., Li B., Bai B. et al. Laboratory features throughout the disease course of influenza A (H1N1) virus infection. Clin. Lab. 2013; 59(3-4): 337-342.

35. Spencer D.C., Pienaar N.L., Atkinson P.M. Disturbances of blood coagulation associated with Salmonella typhi infections. J. Infect. 1988; 16(2): 153-161.

36. Sweiss N.J., Salloum R., Gandhi S. et al. Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PLoS One. 2010; 5(2): e9088.

37. Tan E.M., Cohen A.S., Fries J.F. et al. Tan ACR classification. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982; 25: 1271–1277.

38. Taxonera C., Mendoza J.L., Ortega L. et al. Adalimumab reversed a severe lymphopenia in a patient with Crohn's disease. J. Crohns Colitis. 2012; 6(4): 488-491.

39. Tillipman Ladinsky H., Gillispie M., Sriaroon P., Leiding J.W. Thoracic duct injury resulting in abnormal newborn screen. J. Allergy Clin. Immunol. Pract. 2013; 1(6): 583-588.

40. Vaziri N.D., Pahl M.V., Crum A., Norris K. Effect of uremia on structure and function of immune system. J. Ren. Nutr. 2012; 22(1): 149-156.

41. Vignes S., Bellanger J. Primary intestinal lymphangiectasia (Waldmann’s disease). Orphanet J. Rare Dis. 2008; 3: 5.

42. Wiwanitkit V. Lymphopenia in severe acute respiratory syndrome: a summary on its frequency. Nepal. Med. Coll. J. 2007; 9(2): 132-133.

43. Yoon J., Gollapudi S., Pahl M., Vaziri N. Naïve and Central Memory T-cell lymphopenia in end-stage renal disease. Kidney Int. 2006; 70: 371–376.

44. Zhang J., Zhao Y., Chen Y. Laboratory findings in patients with avian-origin influenza A (H7N9) virus infections. J. Med. Virol. 2014; 86(5): 895-898.

45. Zheng P., Chang X., Lu Q., Liu Y. Cytopenia and Autoimmune Diseases: a Vicious Cycle fueled by mTOR Dysregulation in Hematopoietic Stem Cells. J. Autoimmun. 2013; 41: 182–187.

46. Zonios D.I., Falloon J., Bennett J.E. et al. Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors. Blood. 2008; 112(2): 287–294.


Review

For citations:


Vatutin N.T., Yeshchenko Y.V. LYMPHOPENIA: THE MAIN CAUSES. The Russian Archives of Internal Medicine. 2016;6(2):22-27. (In Russ.) https://doi.org/10.20514/2226-6704-2016-6-2-22-27

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