DIAGNOSTIC OF NONSECRETORY MULTIPLE MYELOMA (CLINICAL CASE)
https://doi.org/10.20514/2226-6704-2017-7-1-66-70
Abstract
The article presents a clinical case of nonsecretory multiple myeloma, verified with immunohistochemical staining. It was hard to prove the diagnosis as the patient had extramedullar lesions adding to the bone destructions, the bone marrow was minimally infiltrated with plasma cells, ESR was normal, no monoclonal protein was present in the serum and urine.
About the Authors
N. T. Vatutin
M.Gorky Donetsk national medical University
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
N. S. Kovalenko
V.K. Gusak Institute of urgent and reconstructive surgery
Russian Federation
Department of hematology, Donetsk, Ukraine
Russian Federation
Department of hematology, Donetsk, Ukraine
E. V. Sklyannaya
M.Gorky Donetsk national medical University
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
A. N. Zagoruiko
M.Gorky Donetsk national medical University
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
M. A. El-Khatib
M.Gorky Donetsk national medical University
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
Russian Federation
Department of hospital therapy, Donetsk, Ukraine
S. V. Starcenko
V.K. Gusak Institute of urgent and reconstructive surgery
Russian Federation
Department of hematology, Donetsk, Ukraine
Russian Federation
Department of hematology, Donetsk, Ukraine
M. V. Makarova
V.K. Gusak Institute of urgent and reconstructive surgery
Russian Federation
Department of hematology, Donetsk, Ukraine
Russian Federation
Department of hematology, Donetsk, Ukraine
I. G. Lozhechnyk
V.K. Gusak Institute of urgent and reconstructive surgery
Russian Federation
Department of hematology, Donetsk, Ukraine
Russian Federation
Department of hematology, Donetsk, Ukraine
References
1. Андреева Н.Е., Чернохвостова Е.В. Иммуноглобулинопатии. М: Медицины. 1985; 240 с. Andreeva N.Е., Chernohvostova E.V. Immunoglobulinopatii. M: Меdicine. 1985; 240 p. [in Russian].
2. Кемайкин В.М. «Несекретирующая» множественная миелома. Часть 1. Астана медициналық журналы. 2011; 68 (6): 22. Kemajkin V.M. Non secretory multiple myeloma. Part 1. Astana Medical. Journal. 2011; 68 (6): 22 [in Russian].
3. Кравченко Д.В., Ходулева С.А., Новик Д.К. Множественная миелома. Практическое пособие для врачей. Гомель: государственное учреждение «Республиканский научно- практический центр радиационной медицины и экологии человека». 2016: 5. Kravchenko D.V., Hoduleva S.A., Novik D.K. Multiple myeloma. A practical guide for doctors. Gomel: State Institution “Republican Scientific Center for Radiation Medicine and Human Ecology”. 2016: 5 [in Russian].
4. Любимова Н.В., Данилов А.Н., Турко Т.А. и др. Свободные легкие цепи иммуноглобулинов в сыворотке крови больных моноклональными гаммапатиями. Вестник Тамбовского университета. Серия: естественные и технические науки. 2014; 19(1): 36-41. Ljubimova N.V., Danilov A.N., Turko T.A. et al. Free light chains in blood serum of patients with monoclonal gammapathies. Vestnik Tambov University. Series: Natural and Technical Sciences. 2014; 19 (1): 36-41 [in Russian].
5. Моисеев С.И., Салогуб Г.Н., Степанова Н.В. Современные принципы диагностики и лечения множественной миеломы: Пособие. СПб.: Издательство СПбГМУ. 2006: 12. Moiseev S.I., Salogub G.N., Stepanova N.V. Modern principles of diagnosis and treatment of multiple myeloma: Guideline. SPb.: Publishing office SPbSMU. 2006: 12 [in Russian].
6. Мостовой В.П., Ильясов Р.К., Муравская Ю.В. Проблемы диагностики и лечения несекретирующей формы множественной миеломы. Кримський терапевтичний журнал. 2013; 2: 203. Mostovoj V.P., Il’jasov R.K., Muravskaja U.V. The problems of diagnosis and treatment of non secretory multiple myeloma. Crimean Journal of Internal Diseases. 2013; 2: 203 [in Russian].
7. Национальное гематологическое общество. Российское профессионально общество онкогематологов. Клинические рекомендации по диагностике и лечению множественной миеломы.2014: 3-22. The National Society of Hematology. Russian hematological professional society. Clinical guidelines for the diagnosis and treatment of multiple myeloma. 2014: 3-22 [in Russian].
8. Рыжко В.В., Клодзинский А.А., Варламова Е.Ю. и др. «Несекретирующая» множественная миелома. Клиническая онкогематолгия. 2010; 3(3): 270-277. Ryzhko V.V., Klodzinskij A.A., Varlamova E.U. et al. Non secretory multiple myeloma. Clinical onkogematolgiya. 2010; 3 (3): 270-277 [in Russian].
9. Choy G.G., Niesvizky R., Michaeli. J. Сlin. Immunother. 1995; 4(5): 346-360.
10. DeVita V.T., Hellman S., Rosenberg S.A. Cancer. Principles and Practice of Oncology. Philadelphia: Lippincott-Raven Publishers. 1997; 2(5): 349-373.
11. Hewwel G.M., Alexanian R. Multiple myeloma in young persons. Ann. Intern. Med. 1976; 84: 441-443.
12. Hoffman R., Benz E.B., Shattil S.J. et al. Hematology. Basic Principles and Practice. 1995(Ed.2nd): 323.
13. Low S.F., Mohd Tap N.H., Kew T.Y. et al. Non Secretory Multiple Myeloma With Extensive Extramedullary Plasmacytoma: A Diagnostic Dilemma. Iran J Radiol. 2015; 12(3): 11760.
Review
For citations:
Vatutin N.T., Kovalenko N.S., Sklyannaya E.V., Zagoruiko A.N., El-Khatib M.A., Starcenko S.V., Makarova M.V., Lozhechnyk I.G. DIAGNOSTIC OF NONSECRETORY MULTIPLE MYELOMA (CLINICAL CASE). The Russian Archives of Internal Medicine. 2017;7(1):66-70. (In Russ.) https://doi.org/10.20514/2226-6704-2017-7-1-66-70
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