LEVEL OF ZINC AND ITS FRACTIONS AS REFLECTION OF A CONDITION OF ANTIOXIDANT SYSTEM AT THE CHRONIC OBSTRUCTIVE LUNG DISEASE

Objective. To estimate a possibility of use of zinc and its fractions as the indicator reflecting a condition of antioxidant system at sick HOBL and persons from risk groups. Materials and methods. Patients with COPD, smokers and non-smoking healthy people have participated in a research. Everything participated in a research has carried out spirometry with definition of an indicator of FEV1 and the subsequent calculation of FEV1 % of due. Taking into account importance of the occupied role when forming COPD of an oxidative stress have been determined the level of activity of the main enzyme of antitoskidantny protection — superoxide dismutases; level of zinc and its fractions as main component of enzyme and also albumine as main tranporter of metabolic active zinc. The indicator “a share of the related fraction of zinc” for definition of changes in fractions of zinc is entered. Results of the study. It is defined that at the smoking patients with the minimum malfunction of external breath of change of indicators are similar to that at patients with COPD. Statistically significant differences in the level of the studied indicators at non-smoking patients are also revealed. With use of the correlation analysis of Spirmen reliable high correlation communications between FEV1 % from due and activity level superoxide dismutases and also between activity level superoxide dismutases and the general level of zinc and also zinc connected are defined that confirms a hypothesis of a possibility of use of level of zinc and its fractions as the indicator reflecting a condition of antioxidant system at the smoking persons at screening researches. 

1. Global Strategy for the Diagnosis, Management and Prevention of COPD 2017

2. Петрова И.В. , Аль-Табиб М.М., Фархутдинов Р.Р. Изменение процессов свободнорадикального окисления под действием табачного дыма in vitro и in vivo. Медицинский вестник Башкортостана. 2013; 6(8): 165-167. Petrova I.V. , Al’-Tabib M.M., Farhutdinov R.R. Change of processes of free radical oxidation under the influence of tobacco in vitro and in Vivo. Medicinskij vestnik Bashkortostana.2013; 6(8): 165-167 [in Russian].

3. Григорьева Н.Ю. Кузнецов А.Н., Шарабрин Е.Г. Григорьева Н.Ю. Кузнецов А.Н., Шарабрин Е.Г. ХОБЛ: новое о патогенетических механизмах. Современные технологии в медицине. 2011; 1: 112-116. Grigor’eva N.Ju. Kuznecov A.N., Sharabrin E.G. COPD — new about pathogenetic mechanisms. Sovremennye tehnologii v medicine. 2011; 1: 112-116 [in Russian].

4. Кокосов А.Н., ред. Хронический бронхит и обструктивная болезнь легких. СПб; 2002; 286 с. Kokosov A.N., ed. Chronic bronchitis and obstructive pulmonary disease. SPb; 2002; 286 р. [in Russian].

5. Вознесенский Н.В.. Антиоксидантные свойства и клиническая эффективность флуимуцила (N-ацетилцистеина) при ХОБЛ. Практическая пульмонология. 2004; 3:39-41. Voznesenskij N.V. Antioxidatic properties and clinical performance of Fluimucilum (N-Acetylcysteinum) at COPD. Prakticheskaja pul’monologija. 2004; 3: 39-41 [in Russian].

6. Макарова Е.В., Вахламов В.А.. Варварина Г.Н.. Особенности корреляционных связей между параметрами функции внешнего дыхания и состоянием системы антиоксиданты-оксиданты у молодых курильщиков. Медицинский альманах. 2015; 2(37):145-148. Makarova E.V., Vahlamov V.A.. Varvarina G.N.. Features of correlation communications between parameters of function of external breath and a condition of system antioxidantsoxidizers at young smokers. Medicinskij al’manah. 2015; 2(37): 145-148 [in Russian].

7. Мирсаева Г.Х., Камаева Э.Р., Камилов Ф.Х. Состояние перекисного окисления липидов в тромбоцитах и антиоксидантный статус у больных хронической обструктивной болезнью легких в зависимости от степени тяжести заболевания. Медицинский вестник Башкортостана. 2013; 3(8): 49-52. Mirsaeva G.H., Kamaeva Je.R., Kamilov F.H. Condition of peroxide oxidation of lipids in platelets and the antioxidant status at patients with a chronic obstructive lung disease depending on severity of a disease. Medicinskij vestnik bashkortostana. 2013; 3(8): 49-52 [in Russian].

8. Макарова Е.В., Вахламов В.А., Шония М.Л.. Выявление предикторов развития воспалительного процесса в бронхах начинающих курильщиков. Клиническая медицина. 2015; 3 (7): 77-83. Makarova E.V., Vahlamov V.A., Shonija M.L.. Identification of predictors of development of inflammatory process in bronchial tubes of the beginning smokers. Klinicheskaja medicina. 2015; 3 (7): 77-83 [in Russian].

9. Prasad A.S. Zinc is an oxidant and anti-inflammatory agent: its role in human health. Frontiers in nutrition. 2014; 1(14): 1-10.

10. Ranasinghe P. Effects of zinc suplemention on serum lipids: a systematic review and meta-anlysis. Nutrition & Metabolism. 2015: 16.