S-NGAL and u-NGAL content was examined for 113 acute coronary syndrome (ACS) patients, depending on revascularization strategy. 39 (66,1%) ACS patients had transcutaneous coronary treatment (TCT), 41 myocardial infarction (MI) patients with ST segment rise (MI-STR) had thrombolytic therapy (TLT). Higher s-NGAL and u-NGAL levels were obtained for patients with haemodynamically meaningful stenoses (HMS) of coronary arteries (CA) as compared with patients not having HMS. S-NGAL and u-NGAL content for MI-STR patients was higher for patients receiving non-effective, rather than effective TLT, and for patients with contraindications to TLT. Both s-NGAL and u-NGAL levels were higher for MI-STR patients to whom farmacoinvasive strategy was applied, as compared to using only one revascularization method. 

We analyzed data of ambulatory blood pressure monitoring (ABPM) in 58 treated hypertensive patients with well-controlled office BP. It was demonstrated the high prevalence of masked uncontrolled hypertension (31%) and a blunted nighttime BP decline (38%), associated with a poor treatment efficiency and a high risk of cardiovascular events. These findings were observed more often in aged patients with carbohydrate metabolism disorder, obesity and myocardial hypertrophy. In addition to office BP measurement ABPM should be a priority for patients with elevated CVD risk to assess the effect of hypotensive treatment. 

The review contains an analysis of the literature on the problems of optimization approaches in the treatment of myocardial infarction, as well as methods of risk management. The necessity of the development and implementation of the strategy of risk management in clinical practice of myocardial infarction, as well as tasks that should be solved, managing risk of myocardial infarction. Identified risks and incidents of occupational risks of myocardial infarction. 

Aim of study — to evaluate prevalence of microalbuminuria and its correlation with other risk factors of cardiovascular diseases in Tver. Study was done as a part of regional program of prophylaxis of chronic renal failure. From 150 patients we analyzed: anamnesis, BMI, blood pressure. For all patients we perform test for microalbuminuria (test strips MicroAlbuphan). In 45 patients (30%) creatinine in blood and GFR (Cocraft–Goldt) were measured. Analysis of microalbuminuria allows to reveal patients with risk of cardiovascular diseases. We reveal correlation of microalbuminuria with diabetes mellitus, duration of arterial hypertension, duration of smoking, obesity, GFR. More then 1⁄2 patients demonstrate chronic renal disease of 2 stage. It is very important in case it was found at out-patient department. 

This review is devoted to a problem of interpretations of scientific data in the field of genes polymorphism researches, especially endothelial nitric oxide synthase. It is difficult to evaluate gene associations with variety of clinically significant conditions. To define associations is essential in patients with diabetes mellitus because of its cardiovascular complications. The data about associations gives us abilities to develop new targets and tactics, providing personal approach to a disease management. 

The article discusses the use of cystatin C as an indicator of a more sensitive marker for the diagnosis of early stages of CKD in patients with chronic heart failure (CHF). Indicator cystatin C was significantly higher in patients with CHF compared with healthy aфnd increases with worsening functional class CHF. Glomerular filtration rate by cystatin C to detect a reduction in its earliest beginning with functional class II CHF.

Presentation of hypoxic hepatitis (НН) over the past 20 years have evolved from purely laboratory indicator to important clinical concepts, which has a great practical importance for clinicians. Unfortunately, in clinical practice НН diagnosed in connection with the non-specificity of the clinical manifestations, and lack of awareness of General practitioners about the disease. Most often, the disease is diagnosed in patients in intensive care and is associated with high mortality. In this literature review, we analyzed the available epidemiological and pathogenic data, clinical aspects, high risk factors and possible outcomes of the НН. 

e authors held a comprehensive study for 446 patients with I stage of gallstone disease. It was found that the formation of lithogenic bile is a poor prognostic factor in relation to a possible gall stone formation and it is closely linked to changes in its physical and chemical properties and crystal optics. In the early diagnosis of gallstone disease is essential, along with the use of ultrasound of the biliary tract, to study the composition of bile. 

The article is focused on the theoretical and practical aspects of screening — a modern method of secondary prevention and early detection of the most important chronic non-communicable diseases and their risk factors. The article describes screenings which benefits overwhelm potential harms: for smoking, alcohol abuse, obesity, hypertension, dyslipidemia, type 2 diabetes, osteoporosis, abdominal aortic aneurysm, cervical cancer, breast cancer, colon cancer and lung cancer. 

The article provides the basic criteria of the clinical situation known as «fever of unknown origin» which is an interdisciplinary clinical problem. The main reasons for fever of unknown origin are infectious-inflammatory processes, malignant tumors, non-infectious inflammatory (rheumatic fever, systemic disease) and other diseases. In the group of non-infectious inflammatory diseases among patients with fever of unknown origin Still’s disease in adults occupies an important place. The author discusses the historical aspects of the description of the disease, diagnostic criteria, differential diagnosis of Still’s disease and its place in patients with fever of unknown origin; describes two patients with fever of unknown origin, diagnosed with Still’s disease by a number of features. 

Influence hypoxia on parameters of the metabolic module (lipide a spectrum, lipide peroxidase, antioxidizing activity of blood) and vasodilatum function endothelium is investigated at various pathogenetic variants of an anemia. Development of an anemia, irrespective of conducting mechanism pathogeny and etiology, is accompanied by antiatherogenous changes lipide a spectrum, formation prooxidation stress and dysfunction endothelium. Crucial importance in it plays a degree of weight of an anemia, so expressiveness hypoxia. It is shown, that metabolic to disorganization in conditions of decrease vasodilatum function endothelium, it may be accompanied by occurrence of clinical attributes development ischemic illness of heart. 

Начиная с середины 2013 года в каждом номере журнала «Архивъ внутренней медицины» мы публиковали ситуационные задачи в области терапии и смежных дисциплин. Благодарим всех, кто принял участие, пусть и виртуальное, в этих клинических разборах, и особенно тех, кто присылал ответы на них в адрес редакции. В ближайших номерах журнала мы будем размещать развёрнутые ответы на ранее опубликованные задачи, и у вас есть прекрасная возможность проверить свои знания. 

On the basis of historical documents, memoirs of contemporaries, the authors analyze the clinic and development of atherothrombosis the left femoral artery complicated by gangrene of the limb from which sufferd the well-known historical figures — the king of France Louis XIV. The authors clarify the factors contributing to the emergence of disease, amount of help from the standpoint of the medical ability of those years.

Уважаемые читатели, по традиции очередной номер журнала «Архивъ внутренней медицины» завершает обзор изменений законодательной базы в части, касающейся медицины и фармацевтики. Благодарим за помощь в подготовке материала систему «КонсультантПлюс».