The article is devoted to the up-to-date data of the drug-induced liver diseases (DILD) problem and series of the clinical monitoring accomplished by the author. It contains the DILD risk factors, the main mechanisms and the clinical variants of the liver injuries and the main DILD diagnostics and treatment principles.

The article presents current data on the laboratory diagnosis of urogenital infections. Recommendations on the tactics of the management of patients with clinical and laboratory signs of the urogenital infections are given. The possibility of using various antimicrobials include antiviral was investigated. The choice of drugs for treatment was discussed.

In the last quarter of the twentieth century in various parts of the world there was a significant increase in the frequency of natural-focal rickettsioses, united in a group of tick-borne spotted fevers. The analysis of duration of symptoms in groups of patients with middle severity of illness of Astrakhan rickettsial fever (ARF) depending on age has shown that at patients with ARF is more senior 50 years the long period of an intoxication, longer terms eruption on the top extremities, rash occurrence on the face, the longer duration of pain in muscles, and also lymphadenitis and hepatic augmentation were marked.

Acute cerebral ischemia is an actual problem of modern angioneurology. As a result of pathogenetic mechanisms in acute cerebral ischemia occurs irreversible cell death, or an apoplectic depolarization of neurons. A promising direction in the treatment of ischemic stroke appears to search for effective combinations of drugs that affect different stages of the patobiochemical cascade in acute cerebral ischemia and stimulating regenerative processes in the nervous tissue.

The article cited the case of stress-induced cardiomyopathy Тako-tsubo from 44 year old woman. The complexity of the differential diagnosis of myocardial infarction and stress-induced cardiomyopathy Тako-tsubo, the uncertainty of diagnostic criteria were demonstrated.

The article deals with one of the very interesting and highly relevant aspects of the treatment of bronchial asthma — the transition from the original drug to generic. Practitioners report that Tevakomb (salmeterol + fluticasone, generic) is sufficiently effective in the primary patients. Meanwhile, in patients treated previously with Seretide (salmeterol + fluticasone, the original drug) when transferred on Tevakomb there may be cases of deterioration. Doctor has to analyse these complaints. Physiologically, it is not understandable because the studies indicate no differences between Tevakomb and Seretide in terms of treatment efficacy in patients with bronchial asthma. Thus, the problem lies in the plane of psychology. The article presents recommendations to doctors, therapists, and respiratory therapists about the least painful transition from more expensive Seretide to cost-effective Tevakomb.

In the frame of the WHO “MONICA-MOPSY” representative sample of women aged 25–64 (n = 870) in one of Russian megalopolis district was examined. The prevalence of high personal anxiety in the female population was 60%. Negative health evaluation as “is not very well”, “sick” was in 1.5–3 times higher in women with high level of anxiety which more likely had complaints for their health, but cared about their health not enough. Women with high personal anxiety had higher levels of stress at work and in their family, sleep disturbances and unhealthy lifestyles profile: unsuccessfully attempts to quit smoking; reduced diet behavior and physical activity.

The article presents current data on the diagnosis methods of liver diseases. Recommendations on the management of patients with pathology of the hepatic system on the detection of disease are given. The possibility of using different diagnostic techniques, including ultrasound, serum markers, and histological studies are investigated. The choice of diagnosis method is discussed.

The article is devoted to one of the topical issues of contemporary health care — acute coronary syndrome (ACS). The objective of the study was to evaluate patients who were treated at the Regional Vascular Center during the hospital phase of treatment and to analyze treatment during the outpatient. Besides, the article analyses patients’ compliance, long-term clinical and social consequences of acute coronary syndrome.

From the author’s viewpoint, the theoretical basis of modern medical science and practice is out of date. Once progressive method of clinical and anatomical mapping and classic physiology do not move advance medicine forward. Evidence-based medicine, which is also a product of the basic methods, explores the “horizontal” field of science. The top of medicine in the form of the etiology and pathogenesis of the total of any disease remains elusive. The author proposes to achieve this objective to apply the method of system analysis, in particular, the theory of functional systems of academician P.K. Anokhin.

This article describes clinical and cytogenetic peculiarities of children’s allergic rhinitis. The dates of changes of the functional activity of ribosomal genes at children’s allergic rhinitis are received. It is experimentally established that the general functional activity of ribosomal genes at children’s allergic rhinitis is less than at healthy children. Also indexes of the functional activity of ribosomal genes are interconnected with the indices of the clinical course of allergic rhinitis. It can be additional characteristic during the prognostication of disease development.

Therapeutic service of Kursk region is represented in more than 500 medical practitioners. It participates in the regional target programs in the federal programs, continually improve their work, organize not only medical, but also preventive care to the population. This article presents the characteristics and results of therapeutic service of Kursk region in recent years.