ДИАБЕТИЧЕСКАЯ АВТОНОМНАЯ КАРД ИАЛЬНАЯ НЕЙРОПАТИЯ У БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ 2 ТИПА: ФОКУС НА НЕРЕШЁННЫЕ ПРОБЛЕМЫ
https://doi.org/10.20514/2226-6704-2013-0-3-57-62
Abstract
It is well known that cardiac autonomic neuropathy (CAN) is the negative prognostic factor which increases mortality in patients with diabetes mellitus. CAN may have greater predictive power for cardiovascular events than traditional risk factors. Significant morbidity and mortality can now be attributable to autonomic imbalance between the sympathetic and parasympathetic nervous system regulation of cardiovascular function. This review covers the epidemiology, pathophysiology, clinical presentation, and diagnosis of CAN in diabetes and discusses current evidence on approaches to prevention and treatment of CAN.
About the Authors
М. Е. Стаценко
ГОУ ВПО «Волгоградский государственный медицинский университет»
Russian Federation
кафедра внутренних болезней педиатрического и стоматологического факультетов
Russian Federation
кафедра внутренних болезней педиатрического и стоматологического факультетов
С. В. Туркина
ГОУ ВПО «Волгоградский государственный медицинский университет»
Russian Federation
кафедра внутренних болезней педиатрического и стоматологического факультетов
Russian Federation
кафедра внутренних болезней педиатрического и стоматологического факультетов
References
1. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 5-й выпуск. Сахарный диабет. 2011; 3 (прил). С. 2–72.
2. Мамедов Н.О. Сердечная автономная нейропатия — взгляд кардиолога // Медицинские вести. 2010. № 31 (536).
3. Ткачёва О.Н., Вёрткин А.Л. Диабетическая автономная нейропатия (руководство для врачей). Москва: ГОЭТАР – Медиа, 2009.
4. American Diabetes Association and American Academy of Neurology. Consensus statement: report and recommendations of the San Antonio Conference on Diabetic Neuropathy // Diabetes Care. 1988. Vol. 11. P. 592–597.
5. Asis Kumar Basu, Pankay Sinnghala, PradipP Raychaudhuri et al. A Study on Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus and Its Correlation with Other Microangiopathies eg Nephropathy, Retinopathy. 70th Scientific Sessions. 2010. P. 2270–PO.
6. Bell D. Diabetic Cardiomyopathy // Diabetes Care. 2003. № 26. Р. 2949–2951.
7. Bernardi L., Spallone V., Stevens M., Hilsted J. et al. Methods of investigation for cardiac autonomic dysfunction in human research studies // Diabetes Metab. Res. Rev. 2011. № 27. P. 654–664.
8. Boulton A.J., Vinik A.I., Arezzo J.C. et al. Diabetic neuropathies: a statement by the American Diabetes Association // Diabetes Care. 2005. № 28. P. 956–962.
9. Buse J.B., Ginsberg H.N., Bakris G.L. et al. American Heart Association; American Diabetes Association. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association // Diabetes Care. 2007. № 30. P. 162–172.
10. Cameron N.E., Eaton S.E., Cotter M.A., Tesfaye S. Vascular factors and metabolic interactions in pathogenesis of diabetic neuropathy // Diabetologia. 2001. Vol. 44, № 11. P. 1973–1988.
11. Dinh W., Füth R., Lankisch M. et al. Cardiovascular autonomic neuropathy contributes to left ventricular diastolic dysfunction in subjects with type 2 diabetes and impaired glucose tolerance undergoing coronary angiography // Diabetic Med. 2011. № 28. P. 311–318.
12. Ewing D.J., Clarke B.F. Diagnosis and management of diabetic autonomic neuropathy. BMJ. 1982. № 285. P. 916–918.
13. Ewing D.J., Marty C.N., Young R.J., Clarke B.F. The value of cardiovascular autonomic function tests: 10 years experiences in diabetes // Diabetes Care. 1985. № 8. P. 491–498.
14. Ford E.S. Trends in the risk for coronary heart disease among adults with diagnosed diabetes in the U.S.: findings from the National Health and Nutrition Examination Survey, 1999–2008 // Diabetes Care. 2011. № 34. P. 1337–1343.
15. Gaede P., Vedel P., Parving H.H., Pedersen O. Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised study // Lancet. 1999. № 353. P. 617–622.
16. Hayat S.A., Patel B., Khattar R.S. et al. Diabetic cardiomyopathy: mechanisms, diagnosis and treatment // Clin. Sci. 2004. Vol. 107, № 6. P. 539–557.
17. Kempler P., Tesfaye S., Chaturvedi N. et al. The EURODIAB IDDM Complications Study Group. Autonomic neuropathy is associated with increased cardiovascular risk factors: the EURODIAB IDDM Complications Study // Diabet. Med. 2002. № 19. P. 900–909.
18. Kempler P. Review: Autonomic neuropathy: a marker of cardiovascular risk // British Journal of Diabetes & Vascular Disease. 2003. № 3. P. 84–90.
19. Low P.A., Benrud-Larson L.M., Sletten D.M. et al. Autonomic symptoms and diabetic neuropathy: a population-based study // Diabetes Care. 2004. № 27. P. 2942–2947.
20. Maser R.E., Mitchell B.D., Vinik A.I., Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis // Diabetes Care. 2003. № 26. P. 1895–1901.
21. Pop-Busui R., Kirkwood I., Schmid H. et al. Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction // J. Am. Coll. Cardiol. 2004. № 44. P. 2368–2374.
22. Pop-Busui R., Low P.A., Waberski B.H. et al. DCCT/EDIC Research Group. Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC) // Circulation. 2009. № 119. P. 2886–2893.
23. Rubler S., Dlugash J., Yuceoglu Y.Z. et al. New type of cardiomyopathy associated with diabetic glomerulosclerosis // Am. J. Cardiol. 1972. № 30. P. 595–602.
24. Sacre J.W., Franjic B., Jellis C.L. et al. Association of Cardiac Autonomic Neuropathy With Subclinical Myocardial Dysfunction in Type 2 Diabetes // J. Am. Coll. Cardiol. Img. 2010. № 3. P. 1207–1215.
25. Scott L.A., DipRad D., Peter L. Kench. Cardiac Autonomic Neuropathy in the Diabetic Patient: Does 123I-MIBG Imaging Have a Role to Play in Early Diagnosis? // Journal of nuclear medicine technology. 2004. Vol. 32, № 2. P. 66–71.
26. Seung-Hyun Ko, Shin-Ae Park, Jae-Hyong Cho et al. Progression of Cardiovascular Autonomic Dysfunction in Patients with Type 2 Diabetes // Diabetes Care. 2008. № 31. P. 1832–1836.
27. Tesfaye S., Boulton A.J.M, Dyck P.J. et al. Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments // Diabetes Care. 2010. № 33. P. 2285–2293.
28. Valensi P., Pari`es J., Attali J.R. French Group for Research and Study of Diabetic Neuropathy. Cardiac autonomic neuropathy in diabetic patients: influence of diabetes duration, obesity, and microangiopathic complications – the French multicenter study // Metabolism. 2003. № 52. P. 815–820.
29. Valensi P., Sachs R.N., Harfouche B. et al. Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent mycardial ischemia // Diabetes Care. 2001. № 24. P. 339–343.
30. Vinik A.I., Maser R.E., Mitchell B.D., Freeman R. Diabetic autonomic neuropathy // Diabetes Care. 2003. № 26. P. 1553–1579.
31. Vinic A.L., Maser R.E., Zigler D. Autonomic imbalance: prophet of doom or scope for hope? // Diabet. Med. 2011. Vol. 28, № 6. P. 643–651.
32. Vinik A.I., Ziegler D. Diabetic cardiovascular autonomic neuropathy // Circulation. 2007. № 115. P. 387–397.
33. Wackers F.J., Young L.H., Inzucchi S.E. et al. Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study // Diabetes Care. 2004. № 27. P. 1954–1961.
34. Ziegler D., Gries F.A., Muhlen H. et al. Prevalence and clinical correlates of cardiovascular autonomic and peripheral diabetic neuropathy in patients attending diabetes center. The DiaCAN Multicenter Study Group // Diabetes Metab. 1993. № 19. P. 143–151.
35. Ziegler D., Schatz H., Conrad F. et al. Effects of threatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multi-center trial (DEKAN Study) // Diabetes Care. 1997. № 20. P. 369–373.
Review
For citations:
Стаценко М.Е., Туркина С.В. ДИАБЕТИЧЕСКАЯ АВТОНОМНАЯ КАРД ИАЛЬНАЯ НЕЙРОПАТИЯ У БОЛЬНЫХ САХАРНЫМ ДИАБЕТОМ 2 ТИПА: ФОКУС НА НЕРЕШЁННЫЕ ПРОБЛЕМЫ. The Russian Archives of Internal Medicine. 2013;(3):57-62. (In Russ.) https://doi.org/10.20514/2226-6704-2013-0-3-57-62
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