Today we know that almost one of three pregnant women suffer from constipation, which undoubtedly reduces quality of life. Genesis of constipation during pregnancy is more or less studied. However, searching for new agents to correct constipation is limited by clear framework — drugs must be safe for the health of the pregnant woman and fetus. Existing or proposed correction methods often have weak evidence base or can't be widely used due to adverse events in women (pain, diarrhea syndrome). All of this requires search for new effective methods of prevention and correction of constipation. Constipation often occur due to disruption of the intestinal microflora in the short term seems more widespread use of probiotics for the correction of constipation in pregnancy. The article provides a theoretical basis for the use of probiotics in pregnant women with constipation and evidence of effective and safe use of certain probiotic strains during pregnancy.

Chronic obstructive pulmonary disease (COPD) is associated with important chronic comorbid diseases. Arterial hypertension (AH) is one of the most frequently occurring comorbidity in COPD. This study was conducted to assess clinical, functional and pathophysiological characteristics in patients with co-existing COPD and AH and in COPD and hypertensive patients. Marked differences have been found among groups. These results suggest that there is a subset of COPD patients with comorbid AH who may represent a distinct phenotype.

We have studied effect of Omacor in the treatment of patients with chronic coronary heart disease (CHD) with diabetes mellitus (DM) type 2 on heart rate variability (HRV) and the severity of ischemic processes in myocardium. It is shown that Omacor taking (1 g/day) in the complex therapy for 3 months leads to improvement of HRV (time and frequency), with more pronounced positive effect in patients without postinfarction cardiosclerosis. Admission of Omacor increases antianginal effects of nitrates and beta-blockers, reduces necessity of using a short-acting nitrates to relieve angina. It allows to recommend to include Omacor in complex treatment of patients with chronic CHD and type 2 DM in order to improve HRV, as well as improving the effectiveness of key antianginal agents.

The holding of pharmacoeconomic studies of ACS with the use of ATC/DDD-methodology in order to optimize therapy, it is important. With the use of ATC/DDD-methodology, to estimate the treatment of 1071 patients with myocardial infarction. Тhe highest consumption of medicines groups Platelet aggregation inhibitors and Heparin group. The 3 place - nitrates, on 4 and 5 locations ACE inhibitors and beta-blockers. Behind them, on the level of consumption are diuretics and antithrombotic drugs. Listed group of drugs accounted for 90% of the volume of drug consumption in the analysis of DU90 by groups of medicines. In carrying out VEN-analysis of the data structure of groups of drug preparations, which are vitally necessary and attributed to the category V, amounted to 77.4% of essential drugs (category E) – 22,6%. Statins, which also belong to the category V, were not included in the group of DU-90%. So, ATC/DDD – methodology allows us to objectively assess the drug supply and significantly expands the capabilities of its analysis and may be widely used in practice.

One of the important problems at the intersection of cardiology and psychiatry is the choice of treatment of mental and neurotic disorders, level in patients with cardiovascular disease (CVD) in a cardiology hospital. Particular significance and the search for preventive agents for the prevention of psychopathology that influence the dynamics of somatic illness. In an open prospective study with a comparison group in a cardiology hospital demonstrated the efficacy and safety of the acute and prophylactic treatment of neuroprotective drugs Pantogam asset (an average dose of 1.8 and 1.2 g/day, respectively), borderline mental disorders in patients undergoing acute coronary syndrome (ACS).

In recent years literature reports of changed course of infective endocarditis (IE) compared to the classical description of the XX century became more frequent. However, there are practically no materials with a description of IE pathomorphism in our literature. The authors of this paper have studied 225 cases of IE in natural and artificial heart valves in mid-2000s., compared them with the observations of 1970's and 80's and 90's and identify a number of extremely interesting for clinicians mechanisms.

The article represents contemporary data on the illness development mechanisms, the main disease manifestation forms and the treatment methods of the alcoholic liver disease. It also covers the disease progression reasons and the main risk factors.

It is considered the possibility of use of an assessment of a condition of haemodynamics by volume compression oscillometry in definition of cardiovascular risk. The scale of prediction of risk in patients with arterial hypertension by the data of volume compression oscillometry and risk factors is developed.

We had analyzed the diagnostic findings of 42 cirrhosis patients with infectious complications in the research. There have been evaluated the diagnostic significance of inflammatory markers determination (endotoxin, D-dimers, C-reactive protein) under out-of-hospital and nosocomial infections and its dynamics during antibacterial therapy.