Essential rapid growth of proteolytic flora, producing significant amount of ammonia gas and end products of protein metabolism, plays important role in the pathogenesis of hepatic encephalopathy (PE) — that substances enter the bloodstream and increase the symptoms of PE. This fact is the basis for pro- and prebiotics use to correct changes in the microflora of the colon in patients with PE. Inclusion of Mukofalk 5 g three times a day in therapy of patients with chronic liver disease promotes regression of clinical symptoms of PE, as well as improving the results of psychometric tests. Prebiotic effect of the drug was demonstrated.

The article is devoted to the tactics of the therapist patients admitted to the surgical department. Rare patient today has one disease, often there are 2–3 and more diseases. Often comorbid therapeutic diseases limited operational activity and determine the prognosis. We developed basing on our own clinical study algorithm of management of patients with comorbid disorders in a given clinical situation: surgery (elective and emergency), and conservative management.

Vertebrogenic diseases of the cervical spine are an urgent problem for many decades. The article discusses the clinical aspects of diagnostics and treatment of cervical radiculopathy, in particular the application of the conservative treatment of the pain syndrome, along with non-steroidal anti-inflammatory drugs of Milgamma neurotropic complex.

In the light of bronchial asthma (BA) incidence rise in Russia and in the world, study of the frequency of osteopenia and methods of correction of bone mass reduction in patients with BA is very important. We have conducted a comprehensive analysis of the problem of osteopenia in patients with BA, calculated indicators of awareness of physicians and patients about this problem and the frequency of osteopenia. A comparative clinical and economic research was realized in which course it was found out, that Natecal D3 (Italfarmaco) is characterized by a good profile of the portability and security, leads to an increase in bone mass even during the 6-month period of treatment, and the № 60 form is especially beneficial from the economic point of view.

The aim of the study was to estimate the impact of renal risk factors (RRF), as well as drug therapy in patients with coronary heart disease and indication for revascularization in the risk of recurrence of angina pectoris. 90 patients with coronary heart disease and indications for the restoration of coronary blood flow were surveyed. The high prevalence of renal risk factors among the patients examined was established. It was revealed that within increase in the maximum risk of recurrence of stenosis of CA the risk of the development of angina pectoris after coronary revascularization is increasing, and with the presence of renal risk factors (microalbuminuria, β2-microglobulinuria, and chronic kidney disease), there is an additional increase in the risk of recurrence of angina pectoris. The analysis of the data demonstrated a significant reduction in risk of recurrence of angina pectoris with the ACE inhibitors and metoprolol tartrate prescription before myocardial revascularization.

Total 214 patients with delta infection were examined. Total 48 patients were followed annually during the observation period (2009–2011). Diagnosis of chronic hepatitis delta (CHD) was established in 78,6% (162/206) cases, liver cirrhosis (LC) — in 21,4% (44/206). HDV RNA was detected in 26,2% (56/214) patients. HDV was genotype I. Progression of CL was observed among 31,3% (15/48) of followed patients, decompensation of CL — in 8,3% (4/48), hepatocellular carcinoma — in 4,2% (2/48) cases; mortality was 29,2% (14/48), with hepatic coma and bleeding from esophageal varices as the main cause of death.

The article gives systematicaly organized literature data and the author’s observations of different biliar tract disorder variants. The focus is on the comorbidity formation mechanisms analysis and the difficulties in differential diagnostics of various pathological conditions, associated with the gallbladder pathology and cholepatiae.

Начало читайте в № 4

System analysis itself is a breakthrough in science, and his best concept in the form of the theory of functional systems (FS), created by Academician Petr Kuzmich Anokhin, no doubt, is the value of a breakthrough in the search for etiology and pathogenesis of any disease. It is the opinion of the author, must now change the basic method of studying the disease — a method of clinic and anatomical comparisons, has lost its leading position. However, with the departure from the life of its creator, the theory of FS was not quite relevant and is not widely applied in scientific researches, which inhibited the development of the fundamentals of medicine. Author tries to show that without the use of FS theory to understand the essence of any pathology, and in particular, coronary heart disease will not succeed.

In article taking into account earlier carried out researches and publications possible clinical options of a disease of W.A. Mozart are discussed, including most real of them, according to authors. Causes of the composer’s death are analyzed.