Arterial hypertensia (AH) is one of the most extensive circulatory system diseases. It represents a risk factor of more dangerous complications such as stroke, myocardial infarction, and arterial thrombosis. The existent sufficient quantity of antihypertensive drugs has not solved the problems of decrease of mortality as a consequence of complications, connected with AH. AH patients in the Vologda region were questioned about the accessibility of medicinal drugs and readiness to treatment. The level of satisfaction with the system and ensure the quality of their medicines was estimated. The use of regression method of analysis showed that the doubling of the general practitioners number lead to 49% increase of recognition of the amount of arterial hypertensia cases. Сluster analysis and thematic maps were used for AH of the municipalities. Authors think that decrease of mortality through AH disease complications is influenced by staffing of general practitioners, quality of drugs provision and information awareness for patients about AH treatment.

Simvastatin 40 mg/day prescribed with neuroprotective and antihypertensive treatment in acute stage of ischemic stroke leads to lowering of recurrent cardiovascular events number, positive dynamics of neurological status, regression of endothelial dysfunction, associated with improved renal function.

The management of the patients with atrial fibrillation is the global problem of the modern cardiology and internal medicine because of the associated high mortality risk and severe complications. Drug therapy, especially antithrombotic, becomes a difficult question in case of patient with comorbidity conditions. Though there are some new more effective and safe drugs that becomes more popular and convenient for patients. To reduce the amount of thrombotic complications is the main aspect. And only the outpatient departments can provide patients with atrial fibrillation with the adequate antithrombotic prevention. But nowadays this field doesn’t work as it should according to the European and National Guidelines. So this article speaks about alive and dead patients with atrial fibrillation, about their management in out-patient and in-patient department and about the way they should be treated according to Guidelines.

The article discusses mechanisms of effect of Actovegin in the context of studying its effects on pre-clinical and clinical levels in the treatment of coronary artery disease. Actovegin, obtained by ultrafiltration of calves’ blood, includes more than 200 biological substances. The results of preclinical and clinical studies have shown that Actovegin improves metabolic balance by increasing glucose uptake and oxygen consumption in ischemia, which is the basis of the antioxidant and anti-apoptotic cardioprotection. Multi-factorial and multi-component nature of Actovegin determine its pleiotropic cardioprotective mechanism and clinical efficacy. It was shown by the results of clinical experience treating 46 patients: Actovegin helps to reduce the incidence of reperfusion syndrome in thrombolytic therapy of acute myocardial infarction by almost half, has antiarrythmic effect.

Archiv vnutrenney meditsiny presents material on rational treatment of cough in modern conditions to physicians and communicating specialists. The article states medical practitioner’s points of view on ambroxol (Ambrobene) and clinical cases where this medicine contributed to patients improvement and recovery. Also we show position of ambroxol (Ambrobene) in cough treatment.

The aim of our study is detection of the possible correlation between the degree of inflammation, fibrosis of the liver and the level plasma concentration of metoprolol in the treatment of chronic heart disease. Terminal stages of liver fibrosis characterized by marked reduction of effector T cell function and activity of cells with the potential suppressor (CD4+CD25+), and B-lymphocytes and NK-cells (CD16+SD56+), which play the main role in a cascade of liver damage. In the prolonged ischemia, metabolism of metoprolol is slows and its concentration in the blood is gradually increasing, which subsequently may lead to a enhanced pharmacological effects of metoprolol and more significant blocking of β-receptors.

Having studied the influence of the modern complex of probiotic RioFlora Balance Neo on intestinal microbiota metabolism, the authors concluded that the use of RioFlora Balance Neo restore normal microflora metabolism by stimulating the synthesis of essential functions of the intestine short-chain fatty acids. A significant advantage of probiotic RioFlora Вalance Neo is activation of synthesis of butyrate (butyric acid) — the most important product life of the intestinal microflora, that regulates proliferation of the intestinal mucosa, and provides natural oncoprotective effect.

Risk factors are triggers that lead to oxidative stress, endothelial dysfunction, initiation of apoptosis and energy deficit. This universal mechanism of injury leads to polysystemic defeat and development of comorbide disease. Use of metabolic correctors (Mildronat, particularly) is pathogenetically justified.

In this review there are discussed main steps in oral antidiabetic drugs development. There are presented modern data that concern DPP-4 inhibitors. New advanced perspectives of antidiabetic drugs are also marked.