Transesophageal electric stimulation (TES) is a method of non-invasive cardiac electrophysiology studies. The aim of the study is to evaluate the possibility of TES in the research into atrio-nodal conductions. The scientific innovation is in a non-invasive analysis of the heterogeneity of the refractory period of atrio-nodal connections. 249 patients were examined. By the nature of AV-conduction curve the patients were divided into 2 groups. The first group (109 persons) consisted of the patients with diagnosed transition point (TP). The second group included 140 people, whose V1-V2 dependence of A1-A2 was close to a line — without a TP. It was discovered that the differences in atrio-nodal conductions depend on the effective refractory period of atrioventricular connection. A low index of ERP atrio-nodal conduction is more physiological and accompanied (ERP) by the absence of the increase heart rate under the most further increase the frequency atrial stimulation. A high index of ERP can be caused by different reasons. This variant of atrio-nodal conductions is followed by less favorable changes in hemodynamics.

This article describes clinical and cytogenetic peculiarities of children’s allergic rhinitis. The dates of changes of the functional activity of ribosomal genes at children’s allergic rhinitis are received. It is experimentally established that the general functional activity of ribosomal genes at children’s allergic rhinitis is less than at healthy children. Also indexes of the functional activity of ribosomal genes are interconnected with the indices of the clinical course of allergic rhinitis. It can be additional characteristic during the prognostication of disease development.

The factors supposed to influence on the quality of life in patients with bronchial asthma and arterial hypertension had been examined. MOS SF-36 v2 questionnaire was used. Age, sex, country life, association of the professional occupation with stress had been contributed to decrease in quality of life. Bronchial obstruction and long asthma history correlated with worse parameters of SF-36 v2. Arterial hypotension lower than 120 mm Hg against the background of antihypertensive therapy correlated with decrease in quality of life.

Recommendations for the management of polymyalgia rheumatica are reflected in presented translation of new international guidelines (ACR/EULAR 2015). 

The classification of respiratory viruses and etiological structure in coldly epidemiological period of year 2014 in article, clinical features and differential — diagnostics simptoms of influenza and other acute respiratory infections are presented in detail, modern methods of diagnosis and treatment of influenza and ARVI described, therapeutic and prophylactic doses of drugs for etiological and pathogenesis therapy, the basic directions of specific and nonspecific immunization and preventive vaccination presented in article. 

Human herpes virus type 6 infection is widely distributed. It is extensively studied recent years due to the imperfection of diagnostics, as well as participa- tion in the formation of chronic somatic pathology. According to the international classification 2012, the human herpes virus 6A and human herpesvirus 6B are separate taxonomic units, which vary in sequence of nucleotides, structure, epidemiology, age of infection, the characteristics of flow, sensitivity to therapy. The review contains current data on clinical manifestations, methods of diagnosis and therapy of human herpes virus 6 infectionat different ages. 

In 36 residents of Khanty-Ugra with newly diagnosed gastric and duodenal ulcers evaluated the frequency of symptoms of dyspepsia syndrome and their correlation with morphological rearrangement of the gastric mucosa by the results of histological examination of biopsy samples.
It was revealed that for the first time revealed ulcers manifest a combination of abdominal pain and dyspepsia in 75% of cases. This is a defining pain, verifiable in 92% of newly diagnosed cases of ulcers of the stomach and duodenum. Symptoms proper dyspeptic disorders, represented mostly by two symptoms: nausea and feeling of heaviness in the epigastric region, are more common than morphological manifestations restructuring coolant in the examined patients. The most frequent complication verified bleeding from the newly diagnosed gastric and duodenal ulcers. 

The article presents the results of a prospective clinical study in which 100 patients with H. pylori-associated peptic ulcer disease of stomach/duodenum were examined. The aim of the study was to assess the effect of concomitant anamnestic and clinical factors on the efficacy and safety of eradication therapy (ET). Type 2 diabetes mellitus is a factor that significantly reduces the efficiency of ET with OR 0.21 (95% CI 0,06-0,69, p = 0,0102). Using a macrolide antibiotics prior to ET during the previous 12 months is associated with a reduction in the effectiveness of H. pylori eradication with OR 0.27 (95% CI 0,08-0,90, p = 0,0342). Despite the lack of statistical significance observed negative effect on the efficiency of ET factors such as smoking and increased BMI. Smoking, female gender, age over 50 years and the presence of type 2 diabetes mellitus had no significant impact on the safety profile of ET. 

Goal. Study of the role of risk factors in mechanized gall stone formation depending on sex and age of patients.
Material and methods We examined 210 patients with stage I gallstone disease (GSD). In verification of diagnosis used an ultrasound study of the hepatobiliary system, multi-grade duodenal sounding with subsequent macroscopic, microscopic, chemical and physical examination of bile. In the portions “b” and “C” bile was determined the total concentration of bile acids, cholesterol, with the subsequent calculation it consists of cholesterol ratio. Estimation of surface tension of bile viscosity and bile. In the studied blood levels of total cholesterol, lipoproteins of very low density, lowdensity lipoproteins, high density lipoproteins, triglycerides, were determined the coefficient of atherogenicity. To assess the degree of accumulation of body fat was used the Quetelet index. Studied the relative risk of anamnestic risk factors of GSD.
Results. The features of biliary lithogenesis based on gender and age of patients. High value PR for the gall stone formation are female gender — 3,16, Mature and elderly age (older than 50) of 3.67. In young women, gall-stone formation is mainly due to the increase of cholesterol level of bile, at the age of 50 years with a decline in zhelchnokamennaja pool, increased viscosity and surface tension of bile.
The most important risk factors of cholecystolithiasis are also gender differences: if women is multiple pregnancies and (or) childbirth (more than 3) — OR 4,62, overweight (BMI over 26) — OR is 4.57 and the violation of the principles of good nutrition (eating disorders, overeating or starvation, the use of large quantities of animal fats) — OR 3,94, for men it’s physical inactivity — OR a 4.25, the increase in KA — PR 3.87 and burdened by GSD genetics — OR of 2.05. Conclusion. The data obtained can be used in the organization of dispensary work with patients with hepatobiliary pathology, and to optimize primary prevention of gall stone formation.

The aim: to study features of the cytokine profile in patients with chronic kidney disease receiving treatment by programmed hemodialysis. Materials and methods: the study included 100 patients aged 53,4 ± 15,8 years with chronic kidney disease stage 5D, receiving hemodialysis. All patients were performed a detailed interview to clarify the clinical and anamnestic data, features of pharmacotherapy, physical examination, and complex laboratory research, which included hemogram, biochemical analysis of blood to definition of parameters of kidney function, protein, electrolytes, minerals and iron metabolism, determining the level of interleukin-3 and interleukin-6. Results: anemia was found in 89% of patients, had a normocytic normochromic character with elements of anisocytosis. The most severe anemia was associated with a lower dose of erythropoietin and iron, used in the last month. Interleukin-3 averaged 32,8 ± 8,3 pg / ml, minimum 15 pg / ml, maximum 56 pg / ml, which exceeded reference limits. When comparing the levels of interleukin-3 and erythropoietin dose differing vectors of these parameters in patients with anemia of varying severity were indicated. The correlations between the level of interleukin-3 and the fluctuation of the dose of erythropoietin in the last year (r = 0,54; p = 0,01) in patients with mild anemia, and the level of soluble transferrin receptor (r = 0, 84; p = 0,04) in patients with severe anemia were found. The level of interleukin-6 was also higher than the reference values and amounted to 64,6 ± 8,7 pg / ml, the lowest — 36,0 pg / ml, the most — 86,0 pg / ml. The patients with a high risk of systemic inflammation on the scale of Glasgow Prognostic Score had lower levels of interleukin-6. Conclusions: high levels of interleukin-3 and interleukin-6 were revealed in all patients identified. Inverse relationship of interleukin-3 and dose of erythropoietin in depend of severity of anemia was shown. The high risk of systemic inflammation associated with a lower concentration of interleukin-6, which does not allow its use as a universal marker of inflammation in patients with chronic kidney disease receiving hemodialysis. 

There were examined 86 patients aged 20 to 65 years with a diagnosis of bronchial asthma (BA). The objective is to evaluate the level of disease control, to study the effectiveness, safety and usability when used Foster (beclomethasone dipropionate and formoterol fumarate fixed combination) Combination and Foradil (formoterol fumarate and budesonide in free combination). Patients were divided into 2 groups randomly. The first group received Foster (beclomethasone dipropionate and formoterol fumarate in a fixed combination), and the second group — Foradil Combi (budesonide and formoterol fumarate in a free combination). Results of the study were assessed for 11-13 days and 3 months. The treatment showed a significant reduction in the severity of clinical symptoms in groups 1 and 2. Respiratory function after 3 months in group 1 improved to 17,4 ± 3,2% (p <0.05), and the second at 6,0 ± 3,3% (p> 0.1). Full control of the disease was achieved in one group, 48.83% of patients, and the second at 44.19% of the patients.

The paper presents an analysis of a total of 5650 labor and delivery records of women in maternity departments of the city of Rostovon-Don for 2010-2014. Mean age was 28,26 years. We found out that cardiovascular diseases occurred in 25.58% of cases. There was a significant increase in the prevalence of cardiovascular diseases in pregnant women during 2010-2014. Arrhythmias were indicated typically of all the cases of cardiovascular diseases during pregnancy in 31,7%. Pregnant women with arrhythmias were assessed for concomitant diseases. We also outlined the main principles of patients’ medical attention according to current National Guidelines. 

We investigate the efficiency of the inclusion nootropic drug Pantogam Activ in the complex therapy of 82 patients with heart failure, ischemic heart diseases, anxiety and depressive disorders. It was shown that an 8-week treatment with Pantogam Activ in most patients is accompanied by a significant reduction of anxiety and depressive disorders, increase exercise tolerance, improved autonomic regulation of heart function and decrease the frequency of supraventricular and ventricular arrhythmias, which is accompanied by a marked improvement in the quality of life. 

In analytical review describes the pathogenic mechanisms of hepatocarcinogenesis and some risk factors of grow more serious progress of HCC. There modern classifications of HCC, aetiology, some of diagnostic methods in suspicion on HCC and different variants of treatment by means of medical drugs and nonmedical tactics are presented. The main risk factors for the development HCC — liver cirrhosis, man, the age of 50 year, HBV DNA > 104 copies/ml, positive HBeAg in blood serum, genotype С HBV, mutations in the area core promoter, increased activity ALT. The clinical example of patient with HCC and the outcome of liver cirrhosis are illustrated. 

The article presents the clinical, diagnostic and treatment features of pneumocystis pneumonia in HIV-infected patients. The clinical case of diagnosis verification in a patient 58 years old with severe respiratory failure is described.